Evolución clínica y nutricional de pacientes sometidos a cirugía bariátrica en un hospital de referencia del estado de Pernambuco / Evolução clínica e nutricional de pacientes submetidos à cirurgia bariátrica em um hospital de referência do estado de Pernambuco / Clinical and nutritional evolution of patients undergoing bariatric surgery in a reference hospital in the state of Pernambuco

La obesidad es un factor de riesgo para enfermedades crónicas no transmisibles como Diabetes Mellitus 2, Hipertensión Arterial Sistémica, entre otras. La gastroplastia se encuentra entre las alternativas terapéuticas con buena respuesta a la pérdida de peso cuando el ejercicio físico y la dieta no fueron eficientes, resultando en un mejor control clínico de las comorbilidades asociadas. Por tanto, analizar la evolución clínica y nutricional de pacientes sometidos a cirugía bariátrica, 12 meses después del procedimiento, con el fin de observar los impactos de esta terapia. Se realizó una serie de casos, que incluyeron individuos sometidos a cirugía bariátrica y que presentaban alguna comorbilidad asociada al exceso de peso. La recolección de datos se realizó en Instituto de Medicina Integral Prof. Fernando Figueira – IMIP, ubicado en la ciudad de Recife-Pernambuco, período de mayo de 2021 a octubre de 2021. Se obtuvieron datos antropométricos, clínicos y bioquímicos. Se incluyeron en el estudio cuarenta personas con una edad media de 43 ± 11,7 años, siendo la técnica quirúrgica más utilizada el Bypass Gástrico (77,5%). Se observó una reducción de la Hemoglobina Glicada de 5,8% ± 0,5 en el preoperatorio a 5,1% ± 0,2 a los 12 meses (p = <0,001), y una reducción del Colesterol Total de 199,0 mg/dL a 167,0 mg/dL (p = <0,001) antes y 12 meses después de la gastroplastia, respectivamente. Además de estas, observamos una mejora estadísticamente significativa en todas las variables antropométricas y bioquímicas analizadas, excepto la glucemia en ayunas. Estos resultados pueden explicarse por cambios en la secreción de hormonas intestinales, que ayudan a mejorar el control de la glucosa, los lípidos y la presión arterial, además de la pérdida de peso. Por tanto, la cirugía bariátrica parece tener un impacto positivo en la evolución bioquímica y antropométrica en el primer año tras la cirugía.(AU)

Introdução: A obesidade é fator de risco para doençascrônicas não transmissíveis como Diabetes Mellitus tipo 2,Hipertensão Arterial Sistêmica, dislipidemias, entre outras. Agastroplastia está entre as alternativas terapêuticas com boaresposta sobre a perda ponderal quando exercício físico edieta não foram eficientes, resultando em melhor controle clí-nico de comorbidades associadas. Portanto, analisar a evolu-ção clínica e nutricional de pacientes submetidos à cirurgiabariátrica em um hospital de referência no estado dePernambuco, 12 meses após o procedimento, a fim de obser-var os impactos desta terapêutica. Material e métodos: Foi realizado uma série de casos,que incluiu indivíduos submetidos à cirurgia bariátrica e quepossuíam alguma comorbidade associada ao excesso ponde-ral. A coleta de dados foi realizada no ambulatório de nutri-ção do Instituto de Medicina Integral Prof. Fernando Figueira– IMIP, localizado na cidade de Recife-Pernambuco, períodode maio de 2021 a outubro de 2021. Sendo obtidos dados an-tropométricos, clínicos e bioquímicos. Resultados: Foram incluídos no estudo 40 indivíduos comidade média de 43 ± 11,7 anos, com predominância do sexo feminino (92,5%), sendo a técnica cirúrgica mais realizada oBypass Gástrico (77,5%). Foi observado redução daHemoglobina Glicada de 5,8% ± 0,5 no pré-operatório para5,1% ± 0,2 aos 12 meses (p = <0,001), e redução doColesterol Total de 199,0mg/dL para 167,0mg/dL (p = <0,001)antes e 12 meses após a gastroplastia, respectivamente. Alémdestas, observamos melhora estatisticamente significativa emtodas as variáveis antropométricas e bioquímicas analisadas,exceto a glicemia em jejum. Discussão: Tais resultados podem ser explicados a partirdas alterações da secreção de hormônios intestinais, que au-xiliam no melhor controle glicídico, lipídico e pressórico, alémda perda ponderal...AU)

Introduction: Obesity is a risk factor for chronic non-com-municable diseases such as Type 2 Diabetes Mellitus, SystemicArterial Hypertension, dyslipidemia, among others. Gastroplast is among the therapeutic alternatives with a good response toweight loss when physical exercise and diet were not efficient,resulting in better clinical control of associated comorbidities. Therefore, analyze the clinical and nutritional evolution of pa-tients undergoing bariatric surgery in a reference hospital in thestate of Pernambuco, 12 months after the procedure, in orderto observe the impacts of this therapy. Material and methods: A series of cases was carried out,which included individuals who underwent bariatric surgeryand who had some comorbidity associated with excessweight. Data collection was carried out at the nutrition out-patient clinic of the Instituto de Medicina Integral Prof.Fernando Figueira – IMIP, located in the city of Recife-Pernambuco, period from May 2021 to October 2021.Anthropometric, clinical and biochemical data were obtained. Results: 40 individuals were included in the study with amean age of 43 ± 11.7 years, with a predominance of fema-les (92.5%), with the most common surgical technique beingGastric Bypass (77.5%). A reduction in Glycated Hemoglobinwas observed from 5.8% ± 0.5 in the preoperative period to5.1% ± 0.2 at 12 months (p = <0.001), and a reduction inTotal Cholesterol from 199.0mg/dL to 167.0mg/dL (p =<0.001) before and 12 months after gastroplasty, respecti-vely. In addition to these, we observed a statistically signifi-cant improvement in all anthropometric and biochemical va-riables analyzed, except fasting blood glucose. Discussion: These results can be explained based onchanges in the secretion of intestinal hormones, which helpwith better glucose, lipid and blood pressure control, in addi-tion to weight loss...(AU)

Associação entre o consumo alimentar e o estado nutricional de pacientes com alterações hepáticas / Association between food consumption and the nutritional status of patients with hepatic disorders

Introduction: Chronic liver diseases induce changes in the intermediary metabolism of macronutrients and micronutrients, related to the degree of liver impairment, influencing the nutritional status of patients. Thus, the reduction in dietary intake is one of the main etiological components of malnutrition, being a clinical-social pathology. These factors have impactful consequences on the evolution of the patient’s clinical status, worsening the prognosis, with an increase in the length of hospital stay and the incidence of complications.Objective: To evaluate the dietary intake and nutritionalstatus of patients with liver disease.Materials and Methods: This is a cross-sectional studycarried out with patients with chronic liver disease, treated at the hepatology outpatient clinic of Instituto de MedicinaProfessor Fernando Figueira (IMIP) between December 2020and May 2021. The sample was selected for convenience. and with patients older than 18 years. Data were obtainedthrough interviews covering information about the socioeconomic and demographic profile, food consumption, lifestyle and medical history. The assessment of habitual food consumption was performed using the semiquantitative Food Frequency Questionnaire validated.Results: Fifty-six patients were evaluated, in which 44.6%were overweight when evaluating the body mass index (BMI), and eutrophy according to the corrected arm muscle area (AMBC), arm circumference (AC), arm muscle circumference (AMC) and calf circumference (CP). A correlation was observed between higher consumption of oilseeds (p=0.009), cereals, tubers and roots (p=0.008), sweets and sweets (p=0.005), with AMBc adequacy, in addition to higher consumption of sweets and sweets, associated with adequacy according to the parameters of AC (p=0.043) and CP (p=0.040). Thus, a positive correlation was observed only between these parameters...(AU)

Introdução: As doenças hepáticas crônicas induzem altera-ções no metabolismo intermediário dos macronutrientes e mi-cronutrientes, relacionados ao grau de comprometimento do fí-gado, influenciando negativamente no estado nutricional dospacientes. Assim, a redução da ingestão dietética é um dos prin-cipais componentes etiológicos da desnutrição, sendo uma pa-tologia de caráter clínico-social. Esses fatores provocam conse-quências impactantes no estado clínico e evolução do paciente,piorando o prognóstico, com aumento no tempo de internaçãohospitalar e na incidência de infecções e complicações. Objetivo: Avaliar o consumo alimentar e o estado nutricional de pacientes com doenças hepáticas. Materiais e Métodos: Tratase de um estudo transversalrealizado com os pacientes com doença hepática crônica,atendidos no ambulatório de hepatologia do Instituto de Medicina Professor Fernando Figueira (IMIP) entre dezembrode 2020 a maio de 2021. A amostra foi selecionada por con-veniência e com pacientes maiores de 18 anos. Os dados foram obtidos por meio de entrevista abrangendo informaçõessobre o perfil socioeconômico, demográfico, o consumo ali-mentar, estilo de vida e história clínica. A avaliação do con-sumo alimentar habitual foi realizada pelo Questionário deFrequência Alimentar Semiquantitativo validado. Resultados: Foram avaliados 56 pacientes, em que 44,6%apresentaram excesso de peso ao avaliar o índice de massacorporal e eutrofia de acordo com a área muscular do braçocorrigido, circunferência de braço, circunferência muscular dobraço e circunferência da panturrilha. Foi observada uma correlação entre o maior consumo de oleaginosas, cereais, tu-bérculos e raízes, doces e guloseimas, além do maior consumo de doces e guloseimas. Assim, sendo observada umacorrelação positiva apenas entre esses parâmetros...(AU)

Qualidade da dieta e fatores associados em pacientes adultos e idosos atendidos em um ambulatório de nutrição na cidade de Recife, Pernambuco / Diet quality and associated factors in adult and elderly patients treated in a nutrition outpatient clinic in the city of Recife, Pernambuco

O consumo alimentar atual, caracterizado pelo aumento da ingestão de alimentos de alta densidade calórica e baixo valor nutricional pode influenciar negativamente no estado nutricional e surgimento de agravos à saúde. Este estudo teve como objetivo avaliar a qualidade da dieta e fatores associados em pacientes adultos e idosos atendidos num ambulatório de nutrição. Trata-se de um estudo transversal realizado de maio a outubro de 2021 no ambulatório de nutrição do Instituto de Medicina Integral Prof. Fernando Figueira em Recife, Pernambuco. Foram coletadas as informações do perfil sociodemográfico e econômico, estilo de vida, variáveis clínicas e estado nutricional, no momento do atendimento nutricional (primeira consulta e/ou consulta de acompanhamento). A avaliação do consumo alimentar foi realizada por meio da análise do Índice de Qualidade da Dieta Revisado (IQDR). A amostra foi composta por 102 pacientes, e foi evidenciada uma maior frequência de excesso de peso/obesidade e risco cardiovascular muito elevado. Com relação ao IQDR, 72,6% da amostra apresentam dieta saudável. O tempo de acompanhamento foi correlacionado positivamente com a qualidade da dieta (ρ 0,199; p<0,045); e quanto à glicemia de jejum, houve uma correlação negativa com o consumo de cereais totais (ρ -0,229; p<0,050), e positiva com o consumo de leite e derivados (ρ0,265; p<0,023). No que se refere às variáveis antropométricas, evidenciou-se correlações negativas com o consumo de hortifrútis e cereais integrais. O consumo alimentar é considerado complexo e necessita da avaliação dos fatores que possam interferir no mesmo. O acompanhamento nutricional, a modificação e a melhora da qualidade da alimentação, favorecem à adoção de um estilo de vida mais saudável, relacionando-se com a prevenção e/ou o controle das doenças crônicas não transmissíveis e suas complicações.

Current food consumption, characterized by increased intake of high-density foods and low nutritional value can negatively influence nutritional status and the emergence of health problems. This study aimed to evaluate the quality of the diet and associated factors in adult and elderly patients treated in a nutrition outpatient clinic. This is a cross-sectional study conducted from May to October 2021 at the Nutrition Outpatient Unit of the Fernando Figueira Institute of Integral Medicine in Recife, Pernambuco. The information of the sociodemographic and economic profile, lifestyle, clinical variables, and nutritional status was collected at the time of nutritional consultation (first consultation and/or follow-up consultation). The evaluation of food consumption was performed through the analysis of the Diet Quality Index - Revised (DQI-R). The sample consisted of 102 patients, and there was a higher frequency of overweight/obesity and very high cardiovascular risk. Regarding DQI-R, 72.6% of the sample has a healthy diet. The follow-up time was positively correlated with the quality of the diet (ρ 0.199; p <0.045); and regarding fasting blood glucose, there was a negative correlation with the consumption of total cereals (ρ -0.229; p <0.050) and a positive correlation with the consumption of milk and derivatives (ρ 0.265; p <0.023). Regarding anthropometric variables, negative correlations with the consumption of whole grains and cereals was demonstrated. Food consumption is considered complex and requires the evaluation of factors that may interfere with it. Nutritional monitoring, modifying, and improving the quality of food, favors the adoption of a healthier lifestyle, which relates to the prevention and/or control of chronic non-communicable diseases and their complications.

Comparison between GLIM and PG-SGA methods in the nutritional assessment of hospitalized oncological patients / Comparação entre os métodos GLIM e ASG-PPP na avaliação nutricional de pacientes oncológicos hospitalizados

ABSTRACT Objective The aim of this study was to compare the Global Leadership Initiative on Malnutrition and Subjective Global Assessment methods produced by the patient in the nutritional assessment of cancer in-patients. Methods Cross-sectional study with a prospective variable, conducted with patients admitted to a public hospital in Pernambuco, Brazil. The application of these tools and the diagnosis of malnutrition were performed within the first 48 hours of admission. Sociodemographic, clinical and laboratory data were obtained from the medical records and weight, height, arm circumference, triceps skinfold and handgrip strength data were collected. Results The 82 patients evaluated included mostly men aged ≥ 60 years with less than 8 years education. Malnutrition frequency was 93.7% according to the Subjective Global Assessment and including 23.2% severe malnutrition while, according to the Global Leadership Initiative on Malnutrition, 50% of the patients were considered severely malnourished. Malnutrition by the Global Leadership Initiative on Malnutrition showed a sensitivity of 82.9% and when associated with handgrip strength sensitivity was 90.8%, considering the Subjective global assessment produced by the patient as a reference; on the other hand, the specificity was 16.7% independently of adding handgrip strength. None of the anthropometric variables was associated with the reference tool. Conclusion The Global Leadership Initiative on Malnutrition proved to be a very sensitive tool for diagnosing malnutrition when compared to the gold standard, particularly for severe malnutrition, but with little specificity. The need for a comprehensive nutritional assessment in the clinical practice was confirmed, using the parameters available and not interpreting them separately.

RESUMO Objetivo O objetivo deste estudo foi comparar os métodos Global Leadership Initiativeon Malnutrition e Avaliação Subjetiva Global Produzida pelo Próprio Paciente na avaliação nutricional de pacientes oncológicos hospitalizados. Métodos Estudo transversal com uma variável prospectiva, realizado com pacientes internados em um hospital público de Pernambuco. A aplicação dessas ferramentas e o diagnóstico de desnutrição foram realizados nas primeiras 48 horas de admissão. Dados sociodemográficos, clínicos e laboratoriais foram obtidos do prontuário, e dados com peso, altura, circunferência do braço, prega cutânea tricipital e força de preensão palmar foram coletados. Resultados Dos 82 pacientes avaliados, a maioria eram homens com idade ≥60 anos com menos de 8 anos de estudo. A frequência de desnutrição foi de 93,7% pela Avaliação Subjetiva Global; destes, 23,2% com desnutrição grave. Já pela Global Leadership Initiative on Malnutrition, 50% dos pacientes foram considerados desnutridos graves. A desnutrição pela Global Leadership Initiative on Malnutrition apresentou uma sensibilidade de 82,9% e de 90,8% quando associada à força de preensão palmar considerando a Avaliação Subjetiva Global Produzida pelo Próprio Paciente como referência. Por sua vez, a especificidade foi de 16,7% independentemente de adicionar a força de preensão palmar. Nenhuma das variáveis antropométricas apresentou associação com a ferramenta de referência. Conclusão A Global Leadership Initiative on Malnutrition mostrou-se uma ferramenta bastante sensível para diagnosticar desnutrição quando comparada ao padrão ouro, principalmente para desnutrição grave, porém pouco específica. Ratificou-se a necessidade de uma avaliação nutricional ampla na prática clínica, utilizando os parâmetros disponíveis e não os interpretando de forma isolada.

Nutritional parameters and clinical outcomes of patients admited with COVID-19 in a university hospital / Parâmetros nutricionais e desfechos clínicos de pacientes admitidos com COVID-19 em um hospital universitário

ABSTRACT Objective To evaluate the relationship between nutritional parameters and clinical factors and the outcome of patients diagnosed with COVID-19. Methods This is a prospective longitudinal study involving patients with COVID-19 infection admitted to a University Hospital in Pernambuco. The sample consisted of individuals aged ≥20 years who tested positive for COVID-19 infection. Nutritional risk was assessed using the recommended screening procedure for this group and the nutritional status using the Body Mass Index. Demographic and clinical variables were transcribed from the medical records. Result There was a predominance of adult inpatients between 20 and 59 years of age (95% CI: 64.6-76.0); nutritional risk was observed in 91.6% of patients and overweight in 58.9% of patients. Age ≥60 years (p=0.03), presence of malignancies and inadequate nutrition (p<0.001) were independent risk factors for in-hospital death. It was also observed that only arterial hypertension (OR 2.34, 95% CI 1.32-4.13, p=0.003) and overweight (OR 1.84, 95% CI 1.05-3.21, p=0.032) were considered independent risk factors for admission of the patients in the Intensive Care Unit. Conclusion Although overweight is a risk factor for admission in the Intensive Care Unit, it was not possible to observe it as a factor for mortality, requiring further studies to determine the mechanisms that interfere in the association between obesity and mortality in those patients.

RESUMO Objetivo Avaliar a relação dos parâmetros nutricionais e fatores clínicos com o desfecho dos pacientes diagnosticados com COVID-19. Métodos Trata-se de um estudo longitudinal prospectivo envolvendo pacientes com infecção por COVID-19 internados em um Hospital Universitário de Pernambuco. A amostra foi constituída por indivíduos com idade ≥20 anos que tiveram resultado positivo para infecção por COVID-19. O risco nutricional foi avaliado por meio de triagem recomendada para este grupo e o estado nutricional por meio do Índice de Massa Corpórea. As variáveis demográficas e clínicas foram transcritas dos prontuários. Resultados Houve predomínio de pacientes adultos entre 20 e 59 anos (95% IC: 64,6-76,0) internados, o risco nutricional foi observado em 91,6% e o excesso de peso em 58,9% dos pacientes. A idade >60 anos (p=0,03), a presença de câncer e aporte nutricional inadequado (p<0,001) foram fatores de risco independente para morte hospitalar. Observou-se também que apenas a hipertensão arterial (OR 2,34, 95% IC 1,32-4,13, p=0,003) e o excesso de peso (OR 1,84, 95% IC 1,05-3,21, p=0,032) foram considerados fatores de risco independentes para a internação do paciente na Unidade de Terapia Intensiva. Conclusão Embora o excesso de peso seja um fator de risco para admissão na Unidade de Terapia Intensiva, não foi possível observá-la como um fator para mortalidade, se fazendo necessários estudos para determinar os mecanismos que interferem na associação entre a obesidade e letalidade desses pacientes.

Association between diet quality index, food and nutrient intake and metabolic parameters in adolescents from Recife, northeastern Brazil.

Nutritional studies shifted the focus of attention to the analysis of food quality, addressing general diet considering the foods, food groups and nutrients included. This study evaluates the association between diet quality index, food and nutrient intake and metabolic parameters of adolescents from Recife, northeastern Brazil. It is a cross-sectional study involving adolescents aged 12 to 19 years. Food intake was assessed using the FFQ to estimate the adapted Diet Quality Index for Adolescents for Brazilians (DQIA-BR-A). The analysis included metabolic parameters (glucose, lipid profile, apo A1 and B, α-1-acid glycoprotein, retinol, ß-carotene, α-tocopherol, 25-hydroxyvitamin D and parathormone). Multiple linear regression analysis between the DQIA-BR-A and daily nutrient intake showed a positive correlation (R2adjusted = 0·29) for linoleic fatty acid, Ca and folate and a negative correlation for oleic fatty acid, carbohydrates and vitamins B2 and C, in addition to a low correlation (R2adjusted < 0·07) with all metabolic parameters. However, the DQIA-BR-A correlated significantly (R2adjusted = 0·62; P < 0·001) with food intake. In this way, the DQIA-BR-A can be considered as an accurate and useful instrument for assessing the overall quality of adolescent diets. The diet of the adolescents was considered to be of moderate quality. Changes are required to ensure a balanced diet, considering the high-sugar intake and consumption of sweets as well as the low consumption of vegetables, milk and dairy products, oils, fats and seeds. Such changes should prioritise the consumption of foods rich in essential fatty acids and poor in saturated fat.

Níveis séricos de vitamina D em pacientes portadores de HIV e sua associação com fatores clínicos e nutricionais / Vitamin D serum levels in HIV patients and its association with clinical and nutritional factors

INTRODUÇÃO: A vitamina D está em evidência devido à sua relação com a promoção de melhor qualidade de vida, inclusive em pacientes com HIV, atribuído, principalmente, à sua atuação no sistema imunológico. OBJETIVOS: Verificar os níveis séricos de vitamina D e sua associação com os fatores clínicos e nutricionais em pacientes portadores de HIV. METODOLOGÍA: Estudo descritivo de corte transversal, realizado entre maio e dezembro de 2018, em um ambulatório do Recife, com pacientes com idade igual ou superior a 18 anos com diagnóstico de HIV que possuíam níveis de vitamina D dosados no último ano. Foram coletadas informações como idade, sexo, tempo de diagnóstico da infecção, medicações antiretrovirais, comorbidades e forma de transmissão do vírus. Para avaliação nutricional, foram mensurados peso, altura, índice de massa corporal, prega cutânea triciptal, circunferência do braço e circunferência muscular do braço. Foram registrados os seguintes exames bioquímicos: células de diferenciação 4, carga viral e perfil lipídico. Para a análise estatística utilizou-se o Programa SPSS versão 13.0. O projeto foi aprovado no Comitê de Ética em pesquisa para seres humanos, obtendo CAAE N° 76950417.9.0000.52.01. RESULTADOS: A amostra foi composta por 64 pacientes. Foi encontrado insuficiência de vitamina D em 35,9% dos participantes. De acordo com o índice de massa corporal, metade da amostra apresentou excesso de peso. Enquanto que, pelos outros parâmetros antropométricos, houveram classificações diferentes. A maioria dos participantes possuía bons níveis de células de diferenciação 4, carga viral e perfil lipídico dentro dos valores de referência. Não houve associação significativa entre hipovitaminose D e as variáveis independentes analisadas. CONCLUSÃO: Concluiu-se que a deficiência de vitamina D nessa população pode ser comum, assim como o excesso de peso, mostrando que nem sempre a desnutrição prevalece como diagnóstico nutricional nesses pacientes, principalmente quando estes fazem uso regular dos antirretrovirais e são acompanhados ambulatorialmente

BACKGROUND: Vitamin D is evidenced due to its relation with the promotion of a better quality of life, including in patients with human immunodeficiency virus, attributed mainly to its performance in the immune system. OBJECTIVES: To verify serum levels of vitamin D and its association with clinical and nutritional factors in patients with human immunodeficiency virus. METHODS: A cross-sectional descriptive study, conducted between May and December 2018, in an infectious disease outpatient clinic in Recife, Brazil with patients aged 18 years and over diagnosed with HIV who had vitamin D levels measured in the last year. Data such as age, gender, time of diagnosis of the infection, antiretroviral medications, comorbidities, and form of virus transmission were collected. For nutritional evaluation, weight, height, body mass index, triceps skinfold, arm circumference and arm circumference were measured. The following biochemical tests were also registered: differentiation cells 4, viral load and lipid profile. For the statistical analysis, the SPSS Program version 13.0 was used. The project was approved by the Research Ethics Committee for humans, obtaining CAAE No.76950417.9.0000.52.01. RESULTS: The sample consisted of 64 patients. Vitamin D insufficiency was found in 35.9% of the participants. According to the body mass index, half of the sample was overweight. While, by the other anthropometric parameters, there were different classifications. Most of the participants had good levels of differentiation 4 cells, viral load and lipid profile within the reference values. There was no significant association between hypovitaminosis D and the independent variables analyzed. CONCLUSION: It was concluded that vitamin D deficiency in this population may be common, as well as being overweight, showing that malnutrition does not always prevail as a nutritional diagnosis in these patients, especially when they take regular antiretrovirals and are followed up outpatient

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Prevalence and factors associated with fat-soluble vitamin deficiency in adolescents.

BACKGROUND: fat-soluble vitamin deficiency may be a health problem not recognized in children and adolescents. OBJECTIVE: to estimate the prevalence and factors associated with the deficiency of vitamins A, D and E among adolescent students from Northeastern Brazil. METHODS: transversal study with adolescents aged 12 to 19 of both genders. A questionnaire to collect socioeconomic and lifestyle data and food intake was applied to adolescents. Then, an anthropometric evaluation and a blood sampling were performed to analyze serum concentrations of retinol, ß-carotene, α-tocopherol and 25-hydroxy vitamin D (25[OH]D). RESULTS: the intake of vitamins A (50.3%), E (94.0%) and D (99.8%), as well as α-tocopherol (88.1%), ß-carotene (74.1%), 25(OH)D (50.9%) and retinol (46.6%) serum levels were mostly deficient/insufficient. An increased risk of α-tocopherol deficiency was observed in girls (PR = 1.11) and an increased risk of 25(OH)D deficiency was observed in boys (PR = 1.41). An increased likelihood of ß-carotene (PR = 1.14) and 25(OH) D (PR = 1.38) insufficiency was observed in overweight individuals. CONCLUSIONS: the adolescents had a deficit in the intake and in serum levels of fat-soluble vitamins. The greatest risk of inadequacy was associated with gender and weight excess. However, the behavior of fat-soluble vitamins in adolescents needs further research.

Prevalence and factors associated with fat-soluble vitamin deficiency in adolescents / Prevalencia y factores asociados a la deficiencia de vitaminas liposolubles en adolescentes

Background: fat-soluble vitamin deficiency may be a health problem not recognized in children and adolescents. Objective: to estimate the prevalence and factors associated with the deficiency of vitamins A, D and E among adolescent students from Northeastern Brazil. Methods: transversal study with adolescents aged 12 to 19 of both genders. A questionnaire to collect socioeconomic and lifestyle data and food intake was applied to adolescents. Then, an anthropometric evaluation and a blood sampling were performed to analyze serum concentrations of retinol, beta-carotene, alfa-tocopherol and 25-hydroxy vitamin D (25[OH]D).Results: the intake of vitamins A (50.3%), E (94.0%) and D (99.8%), as well as alfa-tocopherol (88.1%), beta-carotene (74.1%), 25(OH)D (50.9%) and retinol (46.6%) serum levels were mostly deficient/insufficient. An increased risk of α-tocopherol deficiency was observed in girls (PR = 1.11) and an increased risk of 25(OH)D deficiency was observed in boys (PR = 1.41). An increased likelihood of β-carotene (PR = 1.14) and 25(OH) D (PR = 1.38) insufficiency was observed in overweight individuals. Conclusions: the adolescents had a deficit in the intake and in serum levels of fat-soluble vitamins. The greatest risk of inadequacy was associated with gender and weight excess. However, the behavior of fat-soluble vitamins in adolescents needs further research

Introducción: la deficiencia de vitaminas liposolubles puede ser un problema de salud no reconocido en niños y adolescentes. Objetivo: estimar la prevalencia y los factores asociados a la deficiencia de las vitaminas A, D y E entre adolescentes escolares del nordeste de Brasil. Métodos: estudio transversal con adolescentes de 12 a 19 años de ambos sexos. Se utilizó un cuestionario para la recolección de datos socioeconómicos, de estilo de vida y de consumo alimentario de los adolescentes. A continuación, se realizó la evaluación antropométrica y la recolección de sangre para el análisis de las concentraciones séricas de retinol, beta-caroteno, alfa-tocoferol y 25-hidroxivitamina D (25[OH]D). Resultados: la ingesta de vitaminas A (50,3%), E (94,0%) y D (99,8%), así como los niveles séricos del alfa-tocoferol (88,1%), (R)-caroteno (74,1%), 25(OH)D (50,9%) y retinol (46,6%) se presentaron en su mayoría deficientes/insuficientes. Se observó un mayor riesgo de deficiencia del alfa-tocoferol en las niñas (RP = 1,11), y mayor riesgo de insuficiencia de 25(OH)D en los niños (RP = 1,41), así como mayor probabilidad de insuficiencia del (R)-caroteno (RP = 1,14) y 25(OH)D (RP = 1,38) en el exceso de peso. Conclusiones: los adolescentes presentaron déficit en el consumo y en los niveles séricos de las vitaminas liposolubles. El mayor riesgo de inadecuación estuvo asociado al sexo y el exceso de peso, sin embargo el comportamiento de las vitaminas hiposolubles en los adolescentes necesita una mayor investigación

Preditores antropométricos de hipertensão arterial sistêmica em mulheres afrodescendentes / Anthropometric predictors of hypertension in afro-descendant women

OBJETIVOS: Investigar a associação entre parâmetros antropométricos e hipertensão arterial sistêmica e identificar os melhores preditores antropométricos dessa condição em mulheres afrodescendentes, de comunidades remanescentes de quilombos. MÉTODOS: Estudo transversal realizado com mulheres quilombolas do Estado de Alagoas. Foram investigados pressão arterial, parâmetros antropométricos (índice de massa corporal, circunferência da cintura, razão cintura-quadril, razão cintura-estatura, índice de conicidade, gordura corporal), variáveis sociodemográficas, tabagismo e paridade. As associações entre parâmetros antropométricos e hipertensão arterial sistêmica foram averiguadas por meio da regressão de Poisson com ajuste robusto da variância. A capacidade desses parâmetros em predizer a presença de hipertensão arterial sistêmica foi analisada por meio de curvas ROC (Receiver Operating Characteristic). RESULTADOS: Foram avaliadas 1.553 mulheres, com idades entre 20 e 59 anos. A prevalência de hipertensão arterial sistêmica foi 35,8% e a de excesso de peso foi 48,5%. A presença de hipertensão arterial sistêmica associou-se a índice de massa corporal, circunferência da cintura, razão cintura-quadril, razão cintura-estatura e gordura corporal, mesmo após o ajuste para idade, classe socioeconômica e tabagismo. A partir das curvas ROC, foram encontrados os seguintes pontos de corte: índice de massa corporal ≥26,2 kg/m², circunferência da cintura ≥81,6 cm, razão cintura-quadril ≥0,84, razão cintura-estatura ≥0,54, índice de conicidade ≥1,20 e gordura corporal ≥35,4%. Gordura corporal, razão cintura-quadril e razão cintura-estatura apresentaram igual capacidade em predizer a hipertensão arterial sistêmica. CONCLUSÕES: Todos os indicadores de obesidade global e os de obesidade central, excetuando-se o índice de conicidade, associaram-se à hipertensão arterial sistêmica nessa amostra de mulheres afrodescendentes quilombolas. Os melhores preditores antropométricos de hipertensão arterial sistêmica foram porcentagem de gordura corporal, razão cintura-quadril e razão cintura-estatura. Essas medidas tiveram igual, embora baixo, poder discriminatório para a presença de hipertensão arterial sistêmica nessa população.

AIMS: To determine the association between anthropometric parameters and systemic arterial hypertension and to identify the best anthropometrics predictors of this disease in afro-descendant women from remaining quilombo communities. METHODS: A cross-sectional study was conducted with quilombola women from Alagoas State. Blood pressure, anthropometric parameters (body mass index, waist circumference, waist-to-hip ratio, waist-to-height ratio, conicity index, body fat), sociodemographic variables, smoking and parity were investigated. The associations between anthropometric parameters and systemic arterial hypertension were investigated using Poisson regression with robust variance adjustment. The ability of these parameters to predict the presence of systemic arterial hypertension was analyzed using Receiver Operating Characteristic (ROC) curves. RESULTS: A total of 1,553 women, aged between 20 and 59 years, were evaluated. The prevalence of systemic arterial hypertension was 35.8% and that of overweight was 48.5%. The presence of systemic arterial hypertension was associated with body mass index, waist circumference, waist-to-hip ratio, waist-to-height ratio, and body fat, even after adjusting for age, socioeconomic class, and smoking status. From the ROC curves, the following cutoff points were found: body mass index ≥26.2 kg/m², waist circumference ≥81.6 cm, waist-to-hip ratio ≥0.84, waistto-height ratio ≥0.54, conicity index ≥1.20 and body fat ≥35.4%. Body fat, waist-to-hip ratio and waist-to-waist ratio were equally able to predict systemic arterial hypertension. CONCLUSIONS: All indicators of global obesity and those of central obesity, except for the conicity index, were associated with systemic arterial hypertension in this sample of Afro-descendant quilombola women. Percentage of body fat, waist-to-hip ratio and waist-to-height ratio were the best anthropometric predictors of systemic arterial hypertension. These measures had equal, albeit low, discriminatory power for the presence of systemic arterial hypertension in this population.

The effect of vitamin A supplementation with 400 000 IU vs 200 000 IU on retinol concentrations in the breast milk: A randomized clinical trial.

BACKGROUND & AIMS: The vitamin A nutritional status is marginal for most of the newborns, and the prevention of that deficiency is promoted by breastfeeding. The Ministry of Health of Brazil established the National Vitamin A Supplementation Program, giving mega-doses of this nutrient to women right after delivery, in order to provide adequate vitamin A content in the breast milk and The International Vitamin A Consultative Group has supported the recommendation, to supplement with 400 000 IU of VA immediately after delivery. This study compares retinol concentrations in breast milk (colostrum, 2 and 4 months) from mothers supplemented during immediate postpartum with 400 000 IU versus 200 000 IU of vitamin A. METHODS: A randomized, controlled, triple-blind trial, conducted in two public maternities in Recife, Northeast Brazil. Two hundred and ten mothers were recruited and allocated into two treatment groups: 400 000 IU or 200 000 IU of Vitamin A and monitored for 4 months. RESULTS: There was no significant difference between retinol concentrations in breast milk between treatment groups (400 000 IU vs 200 000 IU) in the studied period: 2 months (p = 0.790) and 4 months (p = 0.279), although a progressive reduction of concentrations throughout the study was observed in both treatment groups, 400 000 IU (p < 0.0001) and 200 000 IU (p < 0.0001). CONCLUSIONS: The absence of an additional effect of a higher dosage justifies the 200 000 IU supplementation, according to the World Health Organization. Registered under ClinicalTrials.gov Identifier No. NCT00742937.

Immune response of severe malnutrition children treated according to the protocol of the World Health Organization / Respuesta inmune de niños con desnutrición grave tratada según el protocolo de la organización mundial de la salud

The aim of the study was to compare the innate immune system of severely malnourished children admitted to the Instituto de Medicina Integral Professor Fernando Figueira and treated according to the protocol of the World Health Organization (WHO) at admission and discharge. An experimental study was conducted with 20 children under two years of age. Ten of them had severe malnutrition and ten were a control group. The malnourished group consisted of hospitalized infants and it was submitted to WHO’s protocol. Children with HIV and re-admitted during the study period were excluded. A blood sample was taken at admission and at discharge. Later, an analysis of blood leukocytes, adherence index, phagocytic capacity, production of free radicals superoxide and nitric oxide was performed. Patients with severe malnutrition at hospital discharge showed improved phagocytic function, release of oxygen radicals and reduction of the number of lymphocytes when compared to the time of admission. When compared to the control group, patients at hospital discharge had lower lymphocyte values and lower production of free radicals. Thus, it can be concluded that the duration of hospitalization was insufficient to restore cell-mediated immunity and microbicide activity (AU)

El objetivo del estudio fue comparar el sistema inmune innato de niños con malnutrición grave ingresados en el Instituto de Medicina Integral Professor Fernando Figueira, tratados de acuerdo con el protocolo de la Organización Mundial de la Salud (OMS), al ingreso y al alta hospitalaria. Se llevó a cabo un estudio experimental con 20 niños menores de dos años de edad, 10 con malnutrición grave y 10 niños del grupo de control. El grupo de malnutridos se compuso de lactantes hospitalizados y sometidos al protocolo de la OMS. Se excluyeron los niños afectados por el HIV y los readmitidos durante el período del estudio. Se recogió una muestra de sangre al ingreso y otra al alta, y posterioriormente se realizó el análisis del perfil leucocitario, y el índice de adherencia, la capacidad fagocítica y la producción de los radicales libres superóxido y óxido nítrico. Los pacientes con malnutrición grave en el alta hospitalaria mostraron mejoría de la función fagocítica, la liberación de radicales oxidantes y la reducción del número de linfocitos en comparación con el ingreso hospitalario. En comparación con el grupo de control, los pacientes en el alta hospitalario presentaron valores más bajos de linfocitos y de producción de radicales libres. Por lo tanto, se puede concluir que el tiempo de hospitalización fue insuficiente para restablecer la inmunidad mediada por células, así como para restaurar la actividad microbicida (AU)

Gastric cancer and associated factors in hospitalized patients / El cáncer gástrico y factores asociados en pacientes hospitalizados

Background: despite the decline in its incidence and mortality rate, gastric cancer continues to be the 4th most common tumor and the 2nd cause of death in the world. Objective(s): to analyze the factors associated with gastric cancer in hospitalized patients. Method: Transversal study of case series type made at Recife hospitals. The data were obtained from a questionnaire adapted from a previously validated model, which consists of socioeconomic factors, eating habits, lifestyle, family history of cancer, infection by H. pylori and anthropometric data. Results: among 33 patients, there was a slight prevalence of women aged ≥ 60, from rural areas, with low education and income levels. According to IMC, 57.6% were eutrophics and 69.7% at nutritional risk when used % PP. It was found that 42.4% did not undergo any examination for H. pylori, 48.5% had a genetic predisposition, 75.8% were sedentary, 60.6% smokers and former smokers, 51.5% addicted to alcohol and 36.4% were overweight patients. There was frequent consumption of salty foods, fried foods, and low intake of fruits, foods containing nitrates / nitrites and inadequate food storage. Conclusion: low socioeconomic status, physical inactivity and inappropriate diet patterns were prevalent factors for gastric cancer in the treated group (AU)

Introducción: a pesar de la disminución de la incidencia y la mortalidad, el cáncer gástrico sigue siendo el cuarto tumor más frecuente y la segunda causa de muerte por cáncer en el mundo. Objetivos: analizar los factores asociados con el cáncer gástrico en pacientes hospitalizados. Método: estudio de corte serie de casos, realizado en hospitales de Recife. Los datos fueron obtenidos a partir de cuestionarios adaptados de un modelo previamente validado, que contenían los problemas socioeconómicos, los hábitos alimentarios, el estilo de vida, los antecedentes familiares de cáncer, la infección por H. pylori y los datos antropométricos. Resultados: de los 33 pacientes, tuvieron un ligero predominio las mujeres con edades ≥ 60 años, de zonas rurales, con bajos niveles de educación e ingresos. De acuerdo con el IMC, el 57,6% fueron normales y el 69,7% en riesgo nutricional cuando se utiliza% PP. Se encontró que el 42,4% no se sometió a examen para H. pylori, el 48,5% tenían una predisposición genética, el 75,8% eran sedentarios, el 60,6% eran fumadores y ex fumadores, el 51,5% eran adictos al alcohol y el 36,4% tenían sobrepeso. Hubo consumo frecuente de alimentos salados, alimentos fritos, baja ingesta de frutas, alimentos que contienen nitratos/ nitritos, así como una inadecuada conservación de los alimentos. Conclusión: el bajo nivel socioeconómico, la inactividad física y los hábitos alimentarios inadecuados fueron factores predominantes para el cáncer gástrico en el grupo analizado (AU)