RESUMEN
A 73-year-old man was admitted with four weeks of intermittent fever. He had a history of total aortic arch replacement for aortic arch aneurysm four years prior. CT scans showed no abnormalities before admission. Repeated blood cultures yielded Streptococcus anginosus and Prevotella melaninogenica, suggesting infective endocarditis (IE). Transesophageal echocardiography revealed a vegetation on the aortic valve, confirming IE. He suddenly presented with massive hematemesis and hypotension. Endoscopy revealed an elevated lesion with a laceration but no active bleeding in the esophagus. CT scans showed a thoracic aneurysm involving the esophagus. A diagnosis of aortoesophageal fistula (AEF) complicated by mycotic thoracic aortic aneurysm (MTAA) was made, and he underwent stent graft interpolation followed by minimally invasive esophagectomy. MTAAs are more prone to rupture than arteriosclerotic aneurysms as they are usually not true but pseudoaneurysms. Antecedent infection, including endocarditis, sepsis, predisposes to MTAA. AEF is a rare but life-threatening cause of gastrointestinal bleeding characterized by Chiari's triad. There have been no reports of such rapid formation of AEF after the graft replacement, as shown here. A recent article reported a rapid formation (16 days) of AEF after thoracic endovascular aortic repair, emphasizing prosthetic infection as the most important risk factor. Our case underscores the importance of suspecting AEF and conducting repeated appropriate examinations even if initial examinations do not reveal any aneurysms.
RESUMEN
We herein report a case of ulcerative colitis (UC) exacerbated by strongyloidiasis. Parasites including Strongyloides stercoralis and Entamoeba histolytica can cause chronic gastrointestinal inflammation and long-lasting symptoms resembling UC. On the other hand, it is not well-known that such organisms can trigger the exacerbation of pre-existing UC. We would like to highlight the importance of recognition of strongyloidiasis in the management of UC patients who have lived in or migrated from endemic regions, such as Asia, Africa, and South America.
Asunto(s)
Colitis Ulcerosa , Strongyloides stercoralis , Estrongiloidiasis , Animales , Humanos , Estrongiloidiasis/complicaciones , Estrongiloidiasis/diagnóstico , Estrongiloidiasis/epidemiología , Colitis Ulcerosa/complicaciones , InflamaciónRESUMEN
A 69-year-old man with a history of pulmonary tuberculosis presented with fever. He tested positive for the QuantiFERON TB-2G and human T-cell lymphotropic virus type 1 antibodies. Imaging revealed a mass in the neck of the gallbladder, with periportal lymph node enlargement and penetration into the duodenum. A definite diagnosis could not be made, even with a subsequent detailed examination. Finally, cholecystectomy and a lymph node biopsy were performed. Histopathology revealed a caseating granuloma in the lymph nodes and in the serosa of the gallbladder, and polymerase chain reaction was positive for tuberculosis. Therefore, the patient was diagnosed with abdominal tuberculosis lymphadenitis extending into the gallbladder and duodenum.
Asunto(s)
Abdomen/virología , Enfermedades Duodenales/virología , Enfermedades de la Vesícula Biliar/virología , Infecciones por HTLV-I/complicaciones , Virus Linfotrópico T Tipo 1 Humano , Tuberculosis Ganglionar/virología , Anciano , Enfermedades de la Vesícula Biliar/patología , Enfermedades de la Vesícula Biliar/cirugía , Humanos , Masculino , Resultado del Tratamiento , Tuberculosis Ganglionar/cirugíaAsunto(s)
Adenocarcinoma/sangre , Antígeno CA-19-9/sangre , Neoplasias del Colon/sangre , Colonoscopía/métodos , Mucosa Intestinal/cirugía , Adenocarcinoma/patología , Adenocarcinoma/cirugía , Biomarcadores de Tumor/sangre , Neoplasias del Colon/patología , Neoplasias del Colon/cirugía , Estudios de Seguimiento , Humanos , Inmunohistoquímica , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Índice de Severidad de la Enfermedad , Factores de TiempoRESUMEN
A 52-year-old man presented with diarrhea and 20 kg weight loss in one year. Enteroscopy showed diffuse yellow-white shaggy mucosa in the duodenum and jejunum. Biopsies of the duodenal mucosa revealed massive infiltration within the lamina propria by foamy macrophages strongly positive for periodic acid-Schiff stain. Electron microscopy demonstrated numerous bacilli within macrophages of the lamina propria. Tropheryma whipplei DNA was detected by polymerase chain reaction. The definitive diagnosis of Whipple's disease was made. Antibiotic therapy dramatically improved his clinical picture. This is the first Japanese case with Whipple's disease diagnosed by electron microscopy and polymerase chain reaction.
Asunto(s)
Ceftriaxona/administración & dosificación , Enfermedad de Whipple/diagnóstico , Enfermedad de Whipple/tratamiento farmacológico , Biopsia con Aguja , ADN Bacteriano/análisis , Estudios de Seguimiento , Humanos , Inmunohistoquímica , Infusiones Intravenosas , Mucosa Intestinal/patología , Mucosa Intestinal/ultraestructura , Japón , Masculino , Microscopía Electrónica , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa/métodos , Medición de Riesgo , Índice de Severidad de la Enfermedad , Resultado del TratamientoRESUMEN
Protein-losing gastroenteropathy (PLG) can occur as a manifestation of various diseases including autoimmune disorders, and optimal therapy of these underlying diseases may be the only effective remedy for PLG. In the present report, we describe a case of a 54-year-old woman with PLG associated with an autoimmune disease, presumably CREST syndrome. She failed to respond to steroid treatment. Subsequently, cyclosporine was initiated, which resulted in a rapid recovery. The patient was successfully treated with low-dose cyclosporine for five years. There has not been, to our knowledge, any report of PLG successfully treated with cyclosporine. Cyclosporine therapy may be effective not only in inducing but also in maintaining complete remission in patients with autoimmune-associated PLG, especially refractory or intolerable to steroids and/or immunosuppressive therapies.
Asunto(s)
Síndrome CREST/tratamiento farmacológico , Ciclosporina/administración & dosificación , Inmunosupresores/administración & dosificación , Enteropatías Perdedoras de Proteínas/diagnóstico , Enteropatías Perdedoras de Proteínas/tratamiento farmacológico , Administración Oral , Biopsia con Aguja , Síndrome CREST/complicaciones , Síndrome CREST/diagnóstico , Síndrome CREST/inmunología , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Duodeno/diagnóstico por imagen , Duodeno/patología , Femenino , Estudios de Seguimiento , Humanos , Inmunohistoquímica , Cuidados a Largo Plazo , Persona de Mediana Edad , Enteropatías Perdedoras de Proteínas/complicaciones , Enteropatías Perdedoras de Proteínas/inmunología , Cintigrafía , Medición de Riesgo , Índice de Severidad de la Enfermedad , Estómago/diagnóstico por imagen , Estómago/patología , Resultado del TratamientoRESUMEN
A 36-year-old woman with ulcerative colitis presented with fever, chest and back pain, and fatigue sensation of the arm. Her upper limb pulses were absent. Angiography showed multiple aneurysms of the aorta and its branches, consistent with Takayasu's arteritis. She showed HLA-B35 but no B52, which is the typical haplotype among the coexistence cases of both diseases. Prednisolone was effective. The possible pathogenic association of the disorders is discussed.