[The effect of plasmapheresis and antianginal therapy on lipid metabolism, eicosanoids and the thrombocytic link of hemostasis in patients with ischemic heart disease]. / Vliianie plazmafereza i antianginal'noi terapii na lipidnyi obmen, éikozanoidy i trombotsitarnoe zveno gemostaza u bol'nykh ishemicheskoi bolezn'iu serdtsa.

A study of 126 patients with stenocardia receiving antianginal treatment was carried out with purpose of evaluating the effect of plasmapheresis on the clinical course of the disease, functional activity of thrombocytes, eicosanoids and lipid metabolism. It was shown that plasmapheresis improves the clinical condition of patients with ischemic heart disease, increases the tolerance to physical loads in patients with stenocardia. The mechanism of action of plasmapheresis is related to improvement of the lipid metabolism, system of eicosanoids, and thrombocytic link of hemostasis.

[Population kinetics of circulating monocytes in health and in patients with ischemic heart disease]. / Populiatsionnaia kinetika monotsitov krovi v norme i u bol'nykh ishemicheskoi bolezn'iu serdtsa.

Population kinetics of monocytes (MC) was studied to prove their participation in atherogenesis. Increased number of cells containing lipids (CCL) in patients with severe stable angina pectoris is demonstrated (42.5 versus 7.4% in healthy persons). This is followed by MC esterase activity enhancement. In patients with angina of effort new types of MC appear (with high peroxidase and low esterase activity) and there is a drastic increase of CCL (more than 56%). The correlation between the number of CCL and indices of blood lipid metabolism in anginal patients is lacking. The results obtained may serve as a criterion for evaluating the degree and exacerbation of coronary atherosclerosis in humans.

[Effect of the calcium antagonist diltiazem on the prostacyclin-thromboxane ratio in the plasma of ischemic heart disease patients]. / Vliianie antagonista kal'tsiia diltiazema na prostatsiklin-tromboksanovoe sootnoshenie v plazme krovi bol'nykh IBS.

Content of prostacyclin and thromboxane was studied in blood plasma of patients with ischemic heart disease after single administration of calcium antagonist diltiazem. The drug caused an increase in content of prostacyclin and in the ratio prostacyclin/thromboxane. Diltiazem appears to differently affect the arachidonic acid metabolism in platelets and endothelial cells that may be involved in therapeutic effect of the drug under conditions of ischemic heart disease.

[The treatment of atherosclerosis and hypertension using extracorporeal therapy methods]. / Lechenie ateroskleroza i gipertonicheskoi bolezni s primeneniem metodov ékstrakorporal'noi terapii.

Extracorporeal techniques (hemosorption, plasmapheresis, thrombocytoplasmapheresis, quantum hemotherapy) were studied for their impact on the clinical course of a disease and some hemostatic parameters in 370 patients with cardiovascular diseases (coronary heart disease, hypertensive disease, lower extremity at atherosclerosis obliterans). They were found to be effective in managing patients with atherosclerosis and arterial hypertension who are refractory to the conventional drug therapy. When there was a positive clinical action of therapy, the patients with coronary heart disease were demonstrated to show better parameters of lipid metabolism, immunological status and blood aggregation control system. The hypotensive effect of plasmapheresis in patients with arterial hypertension was followed by a decrease in pressor hormone levels and peripheral vasodilatation.

[The content of fibronectin, fibrinogen, its degradation products and myoglobin in patients with ischemic heart disease]. / Soderzhanie fibronektina, fibrinogena, produktov ego degradatsii i mioglobina u bol'nykh ishemicheskoi bolezn'iu serdtsa.

ELISA using the test systems and a complex of equipment manufactured by Flow Company was employed to study over time the content of fibronectin, fibrinogen, products of its degradation and myoglobin in 178 patients suffering from coronary heart disease (stable and progressive angina pectoris, acute myocardial infarction). The concentration of myoglobin, fibronectin, fibrinogen and products of its degradation was established to depend on the gravity of coronary heart disease and the tame elapsed since the disease onset. In patients with progressive disease, there was an increased consumption of fibronectin which may be due both to its expenditure during blood coagulation and fulfillment of angioprotective function because of exacerbation of systemic atherosclerosis.

[Pharmacologic correction of microcirculatory disorders and hemosorption in the treatment of patients with ischemic heart disease]. / Farmakologicheskaia korrektsiia narushenii mikrotsirkuliatsii i gemosorbtsiia v lechenii bol'nykh ishemicheskoi bolezn'iu serdtsa.

Patterns of red blood cell hemostasis and microcirculation changes are analysed in 115 chronic coronary patients in the course of purposeful medication and at extracorporeal carbohemoperfusion. Differences in the mechanisms of action of trental, phosphaden and essentiale are identified by means of television capillaroscopy, termography, scanning electron microscopy; the mechanism of the antianginal effect of extracorporeal carbohemoperfusion is specified. A considerable disaggregating effect associated with trental and phosphaden, as well as an essentiale-associated improvement in red blood cell morphology and membrane permeability were demonstrated. Extracorporeal carbohemoperfusion is followed by an improvement of red blood cell hemostasis and microcirculation characteristics and a decrease in plasma lipoproteins.