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1.
Aliment Pharmacol Ther ; 13(12): 1647-52, 1999 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-10594400

RESUMEN

AIM: To evaluate the efficacy of omeprazole plus clarithromycin and furazolidone in Helicobacter pylori eradication and duodenal ulcer healing in Brazilian patients. METHODS: Forty H. pylori-positive patients with duodenal ulcer were randomized to receive 20 mg omeprazole o.m. or b.d. for 1 month plus 500 mg clarithromycin (b.d. ) and 200 mg furazolidone (b.d.) for 1 week. RESULTS: Three months after the end of the treatment the eradication rates were 90% by intention-to-treat analysis, and 97% by per protocol analysis. Mild side-effects were observed in 25 patients, none of whom abandoned the protocol. No difference was observed between the 20 mg and 40 mg omeprazole daily doses. Cure or significant improvement of the symptoms and of the histological alterations were observed after H. pylori eradication. CONCLUSION: Our results demonstrate that clarithromycin and furazolidone in combination with omeprazole are a good alternative for H. pylori eradication in Brazilian patients with duodenal ulcer.


Asunto(s)
Claritromicina/administración & dosificación , Úlcera Duodenal/tratamiento farmacológico , Furazolidona/administración & dosificación , Infecciones por Helicobacter/tratamiento farmacológico , Helicobacter pylori , Omeprazol/administración & dosificación , Adolescente , Adulto , Antibacterianos/administración & dosificación , Antibacterianos/efectos adversos , Antiulcerosos/administración & dosificación , Antiulcerosos/efectos adversos , Brasil , Claritromicina/efectos adversos , Quimioterapia Combinada , Úlcera Duodenal/patología , Endoscopía , Femenino , Furazolidona/efectos adversos , Humanos , Masculino , Persona de Mediana Edad , Omeprazol/efectos adversos , Distribución Aleatoria , Factores de Tiempo
2.
Rev Inst Med Trop Sao Paulo ; 41(4): 255-8, 1999.
Artículo en Inglés | MEDLINE | ID: mdl-10564921

RESUMEN

Outbred male albino mice normal or infected with 30 cercariae of Schistosoma mansoni (LE strain) were submitted to 65% hepatectomy during the acute (70 days) and chronic phase (160 days) phases of the disease. A group of the infected animals was treated with 400 mg/kg of oxamniquine during the acute phase before hepatectomy. Non-infected, infected and treated but not hepatectomized animals were kept as controls. Hepatic regeneration was evaluated by incorporation of tritiated thymidine, intraperitoneally injected into non-hepatectomized and hepatectomized animals, 24 hours after surgery. The results showed that removal of 65% of the hepatic parenchyma, during the acute phase, led to a statistically significant increase of thymidine incorporation, when compared with the uninfected hepatectomized controls. This phenomenon was not observed at the chronic phase. Treatment with oxamniquine administered during the acute phase led to a decrease in thymidine incorporation rate 160 days after infection (90 days after treatment) and 24 hours after hepatectomy. The data suggest that infection with S. mansoni represents a considerable stimulus for the regenerative capacity of the liver during the acute, but not the chronic phase of disease.


Asunto(s)
Hepatectomía , Regeneración Hepática , Oxamniquina/uso terapéutico , Schistosoma mansoni , Esquistosomiasis mansoni/tratamiento farmacológico , Esquistosomicidas/uso terapéutico , Enfermedad Aguda , Animales , Enfermedad Crónica , Masculino , Ratones , Esquistosomiasis mansoni/inducido químicamente , Timidina/metabolismo
3.
Rev. Inst. Med. Trop. Säo Paulo ; 41(4): 255-8, July-Aug. 1999. tab
Artículo en Inglés | LILACS | ID: lil-246836

RESUMEN

Outbred male albino mice normal or infected with 30 cercariae of Schistosoma mansoni (LE strain) were submitted to 65 percent hepatectomy during the acute (70 days) and chronic phase (160 days) phases of the disease. A group of the infected animals was treated with 400 mg/kg of oxamniquine during the acute phase before hepatectomy. Non-infected, infected and treated but not hepatectomized animals were kept as controls. Hepatic regeneration was evaluated by incorporation of tritiated thymidine, intraperitoneally injected into non-hepatectomized and hepatectomized animals, 24 hours after surgery. The results showed that removal of 65 percent of the hepatic parenchyma, during the acute phase, led to a statistically significant increase of thymidine incorporation, when compared with the uninfected hepatectomized controls. This phenomenon was not observed at the chronic phase. Treatment with oxamniquine administered during the acute phase led to a decrease in thymidine incorporation rate 160 days after infection (90 days after treatment) and 24 hours after hepatectomy. The data suggest that infection with S. mansoni represents a considerable stimulus for the regenerative capacity of the liver during the acute, but not the chronic phase of disease


Asunto(s)
Ratones , Animales , Masculino , Hepatectomía , Regeneración Hepática , Oxamniquina/uso terapéutico , Schistosoma mansoni , Esquistosomiasis mansoni/tratamiento farmacológico , Enfermedad Aguda , Enfermedad Crónica , Esquistosomiasis mansoni/inducido químicamente , Timidina/metabolismo
4.
Toxicon ; 36(12): 1833-42, 1998 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-9839667

RESUMEN

Scorpion toxin induces gastric secretion of acid and pepsin in rats. These effects seem to be mediated by the release of acetylcholine and histamine. However, the role of gastrin in the scorpion-toxin-induced gastric secretion is unknown. We describe the effects of the T1 fraction purified from Tityus serrulatus scorpion venom on serum and on antral tissue gastrin levels in anaesthetized rats. Gastrin levels in serum and in the antral mucosa were measured before and at intervals 5, 15, 30, 60, 90 up to 120 min after the intravenous injection of saline or the T1 fraction of scorpion venom (0.25 mg/kg) into anaesthetized rats. Antral G-cells were submitted to immunocytochemistry and electron microscopy. The data on gastrin were correlated with the gastric juice volume, and the acid and pepsin output increases induced by toxin. Scorpion toxin induced a significant increase in volume, acid output and pepsin output of gastric juice and gastrin serum levels 15-60 min after injection. Simultaneous measurements of antral gastrin levels did not show significant effects. The number of dense, intermediate and empty granules per microm(2) in the cytoplasm of antral G-cells was not significantly changed 60 min after saline or toxin injection. Scorpion toxin significantly increased serum gastrin; levels in rats.


Asunto(s)
Ácido Gástrico/metabolismo , Gastrinas/sangre , Pepsina A/metabolismo , Antro Pilórico/ultraestructura , Venenos de Escorpión/farmacología , Acetilcolina/metabolismo , Acetilcolina/farmacología , Anestesia , Animales , División Celular/efectos de los fármacos , Histamina/farmacología , Liberación de Histamina/efectos de los fármacos , Inmunoquímica , Masculino , Microscopía Electrónica , Pepsina A/efectos de los fármacos , Antro Pilórico/metabolismo , Ratas
5.
Rev Hosp Clin Fac Med Sao Paulo ; 53(6): 311-6, 1998.
Artículo en Portugués | MEDLINE | ID: mdl-10413947

RESUMEN

Two hundred and fifty two blood donors HBsAg positive (mean age = 32.6, 91, 7% male) were searched into a transversal study to determine their clinical, laboratorial and histological characteristics. It was also compared the positiviness and negativiness of the serologic markers HBeAg, anti-Hbe and IgM anti-HBc with the values of serum aminotransferases. Hepatomegaly and splenomegaly were detected in 9.9% (25/252) and in 2.4% (6/252) respectively. In 17.5% (44/251) and 28.3% (71/251) the AST and ALT were respectively, over 50 UI/I. The positive frequencies of the various serologic markers of hepatitis B virus in 120 patients were: anti-HBc total in 89.5% (102/114), HBeAg in 25.7% (28/109) anti-Hbe in 67.3% (66/98), IgM anti-HBc in 40.8% (49/120); anti-Delta in 0.0% (0.66). Thirty one patients were submitted to liver biopsy, due do clinical alteration and/or of the aminotransferases. The hystological findings were: normal liver in 16.1% (5/31), non specific hystological alterations in 22.6% (7/31), persistent chronic hepatitis in 22.6% (7/31), active chronic hepatitis in 6.5% (2/31), cirrhosis in 12.9% (4/31), alcoholic hepatitis in 3.2% (1/31), lobular chronic hepatitis in 3.2% (1/31) and alterations exclusively due to schistosomiasis in 12.9% (4/31). Schistosomiasis elements (granuloma and/or Symmers fibrosis) were also notived in 7 patients. The comparative analysis of positiveness and negativeness of the serologic markers with the aminotransferases ("t" test of Student) showed significative difference of the averages (p < 0.05) only in relation to the simultaneous positeveness and negativeness of the HBeAg and IgM anti-HBc (average of AST = 56.11 and ALT = 78.00 when HBeAg and IgM anti-HBc were positive; average of AST = 24.25 and ALT = 27.00 when HBeAg and IgM anti-HBc were negative). According to this study the conclusion are: 1) The presence of two markers (HBeAg and IgM anti-HBc) and not only one determinant of viral replication in asymptomatic HBsAg carriers can strongly indicate a significant biochemical activity suggestive of hepatocellular lesion. 2) The presence of HBeAg in 25.7% (28/109) clearly shows the high rate of carriers with a potential of infectivity. 3) The results of hepatic histology shows that the majority of our patients had either normal liver or mild histological alterations. It is important to notice that only the cases with elevated aminotransferases were submitted to liver biopsies. The alterations caused by schistosomiasis shows, as is well known, the high prevalence of the parasitism in our surroundings. 4) The clinical aspects of the patients studied did not show significant alterations. Risk factors to get the infection were low. The hematologic and biochemical parameters (except aminotransferases) were either normal or just slightly abnormal. It was not detected a statistically significant difference. 5) The co-infections by delta virus was null.


Asunto(s)
Alanina Transaminasa/sangre , Aspartato Aminotransferasas/sangre , Donantes de Sangre , Antígenos de Superficie de la Hepatitis B/sangre , Hepatitis B/diagnóstico , Adulto , Brasil , Estudios de Cohortes , Estudios Transversales , Femenino , Hepatitis B/inmunología , Humanos , Inmunoglobulina M/sangre , Hígado/patología , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas
6.
Int J Parasitol ; 26(12): 1393-5, 1996 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-9024890

RESUMEN

Persistence of down regulation of granuloma size was studied in mice chronically infected with Schistosoma mansoni and cured by chemotherapy. The animals were reinfected at 20-, 50-, 110-, and 140-day intervals after treatment, and sacrificed 60 days post-infection. Reinfected animals were able to modulate the granulomatous inflammatory response, thus preventing a new acute phase. These findings may contribute to the explanation for the decrease of morbidity from human schistosomiasis seen in endemic areas following mass treatment.


Asunto(s)
Granuloma/parasitología , Parasitosis Hepáticas/patología , Oxamniquina/uso terapéutico , Esquistosomiasis mansoni/tratamiento farmacológico , Esquistosomiasis mansoni/patología , Animales , Granuloma/etiología , Inflamación , Parasitosis Hepáticas/tratamiento farmacológico , Ratones , Esquistosomiasis mansoni/complicaciones , Esquistosomicidas/uso terapéutico
8.
Rev Soc Bras Med Trop ; 27(4): 221-6, 1994.
Artículo en Inglés | MEDLINE | ID: mdl-7855364

RESUMEN

In this study, which was undertaken in relation to the histopathologic behavior of two different strains (LE-Belo Horizonte, MG and SJ-São José dos Campos, SP) in infections and reinfections (homologous or heterologous) with Schistosoma mansoni, the authors confirmed a more accentuated pathogenicity of the SJ strain. All the reinfections showed the presence of typical granulomas of the acute phase, when performed either with the same strain (homologous) or with a different strain (heterologous) of the parasite of the primo infection. The possible mechanisms responsible for reactivation of the immunopathologic response in reinfections are discussed.


Asunto(s)
Granuloma/inmunología , Parasitosis Hepáticas/inmunología , Esquistosomiasis mansoni/inmunología , Animales , Granuloma/patología , Parasitosis Hepáticas/patología , Masculino , Ratones , Esquistosomiasis mansoni/clasificación , Esquistosomiasis mansoni/patología
9.
Rev Soc Bras Med Trop ; 27(3): 119-25, 1994.
Artículo en Inglés | MEDLINE | ID: mdl-7972940

RESUMEN

Mice previously infected with Schistosoma mansoni, and cured by specific treatment (400mg/kg oxamniquine, p.o.) in the chronic phase of the disease, were reinfected 20 days after treatment to assess their capacity for modulation of the granulomatous response. Histopathologic examination of the animals' liver, at 60 days after reinfection, evidenced the presence of typical granulomas of the chronic phase in most animals. This infer that the capacity for modulation of the granulomatous response had been maintained, thus preventing a new acute phase of the disease. Conversely, a group of previously infected mice, untreated and submitted to reinfection, showed reactivation of the granulomatous response in 50% of the animals. The possible implications of these findings in human schistosomiasis mansoni are discussed.


Asunto(s)
Granuloma/parasitología , Esquistosomiasis mansoni/tratamiento farmacológico , Animales , Femenino , Granuloma/patología , Hígado/parasitología , Hígado/patología , Ratones , Recurrencia , Esquistosomiasis mansoni/parasitología
10.
Braz J Med Biol Res ; 27(3): 645-53, 1994 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-8081289

RESUMEN

1. Patients with chronic Chagas' disease have abnormally low gastric acid secretion and increased gastrin release both during fasting and after different stimuli. Regardless of the relationship between intragastric acidity and gastrin secretion, it is uncertain whether hypergastrinemia in Chagas' disease is caused by an increased population of antral gastrin (G) cells (hyperplasia) or by enhanced cell activity (hyperfunction). 2. We therefore estimated G cell number in antral biopsies from 16 chagasic patients and 13 control subjects using a peroxidase-anti-peroxidase immunohistochemical technique. All subjects underwent a gastric secretion test to determine peak acid output following intravenous pentagastrin instillation. 3. Antral G cell number in Chagas' disease patients was not significantly different from that observed in the control group (number of cells/mm2, median and (range): 128 (44-284) vs 138 (65-285)). 4. In chagasic patients, peak acid output was significantly lower than in controls (mmol/h, median and (range): 9.819 (3.024-21.564) vs 17.490 (9.423-25.848)). 5. These results suggest that the increase in gastrin release associated with reduced gastric acid secretion in Chagas' disease is mediated by antral G cell hyperfunction rather than by hyperplasia.


Asunto(s)
Enfermedad de Chagas/patología , Acalasia del Esófago/patología , Mucosa Gástrica/patología , Gastrinas/metabolismo , Megacolon/patología , Adulto , Recuento de Células , Enfermedad de Chagas/metabolismo , Enfermedad Crónica , Acalasia del Esófago/metabolismo , Femenino , Ácido Gástrico/metabolismo , Mucosa Gástrica/metabolismo , Humanos , Masculino , Megacolon/metabolismo , Persona de Mediana Edad , Antro Pilórico/metabolismo , Antro Pilórico/patología
11.
Braz. j. med. biol. res ; 27(3): 645-53, Mar. 1994. tab
Artículo en Inglés | LILACS | ID: lil-148937

RESUMEN

1. Patients with chronic Chagas' disease have abnormally low gastric acid secretion and increased gastrin release both during fasting and after different stimuli. Regardless of the relationship between intragastric acidity and gastrin secretion, it is uncertain whether hypergastrinemia in Chagas' disease is caused by an increased population of antral gastrin (G) cells (hyperplasia) or by enhanced cell activity (hyperfunction). 2. We therefore estimated G cell number in antral biopsies from 16 chagasic patients and 13 control subjects using a peroxidase-anti-peroxidase immunohistochemical technique. All subjects underwent a gastric secretion test to determine peak acid output following intravenous pentagastrin instillation. 3. Antral G cell number in Chagas' disease patients was not significantly different from that observed in the control group (number of cells/mm2, median and (range): 128 (44-284) vs 138 (65-285)). 4. In chagasic patients, peak acid output was significantly lower than in controls (mmol/h, median and (range): 9.819 (3.024-21.564) vs 17.490 (9.423-25.848)). 5. These results suggest that the increase in gastrin release associated with reduced gastric acid secretion in Chagas' disease is mediated by antral G cell hyperfunction rather than by hyperplasia


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Acalasia del Esófago/patología , Enfermedad de Chagas/patología , Gastrinas/metabolismo , Megacolon/patología , Mucosa Gástrica/patología , Acalasia del Esófago/metabolismo , Ácido Gástrico , Antro Pilórico/metabolismo , Antro Pilórico/patología , Recuento de Células , Enfermedad Crónica , Enfermedad de Chagas/metabolismo , Megacolon/metabolismo , Mucosa Gástrica/metabolismo
12.
Toxicon ; 29(11): 1395-401, 1991.
Artículo en Inglés | MEDLINE | ID: mdl-1814016

RESUMEN

The effect of a partially purified fraction (T1) and toxin gamma purified from Tityus serrulatus scorpion venom, on gastric mucosa were investigated in anesthetized rats. The animals were injected i.v. with the T1 fraction (37.5 micrograms/100 g) or with saline and 60 min later were sacrificed and the stomachs resected. The gastric juice was measured and stereoscopic examination of the stomachs made. In animals injected with the T1 fraction there was an increase in volume, acidity and pepsin output of rat stomach. The T1 fraction also induced acute gastric injuries in the glandular mucosa, consisting of circular or linear ulcers, and punctiform lesions. Intravenous injection of 20 micrograms/100 g of a pure toxin obtained from Tityus serrulatus scorpion venom (toxin gamma) also induced similar lesions in the rat stomach. Our data indicate that the injection of T1 fraction or toxin gamma are good models to induce acute gastric ulcers in a short period of time in anesthetized rats.


Asunto(s)
Mucosa Gástrica/efectos de los fármacos , Venenos de Escorpión/toxicidad , Animales , Ácido Gástrico/metabolismo , Jugo Gástrico/efectos de los fármacos , Jugo Gástrico/enzimología , Mucosa Gástrica/metabolismo , Mucosa Gástrica/patología , Masculino , Pepsina A/metabolismo , Ratas , Venenos de Escorpión/análisis
13.
Mem Inst Oswaldo Cruz ; 84(2): 213-7, 1989.
Artículo en Portugués | MEDLINE | ID: mdl-2635751

RESUMEN

The authors have determined the mean diameter of granulomas in the liver of mice infected with cercariae from two different and well definite geographic strains of Schistosoma mansoni (LE, Belo Horizonte, MG, and SJ, São José dos Campos, SP). A total of 1,170 granulomas has been measured. Granulomas measured on the 60th day after infection showed larger size than the other ones measured on the 90th day. Modulation of the immunopathologic response was significantly more efficient for the LE strain, whereas the granulomas (with 60 and 90 days) related to SJ strain were significantly larger. Data suggested a higher pathogenicity for the SJ strain. It is speculated whether these findings could explain, in part, the occurrence of regional variations of the anatomo-clinical forms of schistosomiasis.


Asunto(s)
Granuloma/patología , Parasitosis Hepáticas/patología , Animales , Antígenos Helmínticos/inmunología , Granuloma/parasitología , Masculino , Ratones , Schistosoma mansoni/inmunología , Schistosoma mansoni/patogenicidad
14.
Rev. Inst. Med. Trop. Säo Paulo ; 31(1): 7-13, jan.-fev. 1989. ilus, tab
Artículo en Inglés | LILACS | ID: lil-89029

RESUMEN

A injeçäo intravenosa de toxina escorpiônica ( Tityus serrulatus) en ratos normais e infectados pelo Trypanosoma cruzi näo causou alteraçöes morfológicas ultra-estruturais das células enterocromafins-like (ECL) do estômago, embora tenha induzido a aumento significativo da secreçäo do suco gástrico


Asunto(s)
Ratas , Animales , Masculino , Enfermedad de Chagas/patología , Células Enterocromafines/ultraestructura , Venenos de Escorpión/toxicidad , Ácido Gástrico , Enfermedad de Chagas/fisiopatología , Mucosa Gástrica/ultraestructura , Pepsina A/metabolismo
15.
Braz J Med Biol Res ; 22(10): 1229-36, 1989.
Artículo en Inglés | MEDLINE | ID: mdl-2517820

RESUMEN

1. The consequences of acute Trypanosoma cruzi infection for acetylcholine and histamine levels in gastric wall and for mast cells of the stomach were studied in rats. 2. Intraperitoneal infection with 4,000 trypomastigotes/g of a Y strain of Trypanosoma cruzi led to a 4-fold decrease in gastric acetylcholine level and to a 57- and 15-fold increase in histamine content in the membranous and glandular regions of the rat stomach, respectively. 3. Infection of rats with Trypanosoma cruzi also induced a 2- and 4-fold increase in mast cell numbers in the membranous and glandular regions of the muscle layer of the gastric wall, respectively, and a ganglionic inflammatory reaction with predominance of mononuclear cells. 4. We conclude that in acutely Trypanosoma cruzi-infected rats, the reduction of acetylcholine content is due to gastric denervation and that the histamine increase might be secondary to gastric denervation and/or to an increase in the number of mast cells of the gastric wall.


Asunto(s)
Acetilcolina/análisis , Enfermedad de Chagas/metabolismo , Histamina/análisis , Estómago/análisis , Animales , Masculino , Mastocitos/análisis , Mastocitos/fisiología , Plexo Mientérico/patología , Ratas , Ratas Endogámicas , Estómago/patología
16.
Rev Inst Med Trop Sao Paulo ; 31(1): 7-13, 1989.
Artículo en Inglés | MEDLINE | ID: mdl-2510237

RESUMEN

Intravenous injection of scorpion toxin (Tityus serrulatus) in normal and Trypanosoma cruzi infected rats did not cause ultrastructural morphologic changes on enterochromaffin-like (ECL) cells of the stomach, although it induced a significant increase of the gastric secretion. Our data seem to indicate that gastric ECL cells structure is not affected by stimulation with scorpion toxin or by acute infection with T. cruzi in the rat.


Asunto(s)
Enfermedad de Chagas/patología , Sistema Cromafín/ultraestructura , Células Enterocromafines/ultraestructura , Venenos de Escorpión/farmacología , Estómago/ultraestructura , Animales , Ácido Gástrico/metabolismo , Masculino , Pepsina A/metabolismo , Ratas
17.
Braz. j. med. biol. res ; 22(10): 1229-36, 1989. tab, ilus
Artículo en Inglés | LILACS | ID: lil-83383

RESUMEN

The consequences of acute Trypanosoma cruzi infection for acetylcholine and histamine levels in gastric wall and for mast cells of the stomach were studied in rats. Intraperitoneal infection with 4,000 trypomastigotes/g of a Y strain of Trypanosoma cruzi led to a 4-fold decrease in gastric acetylcholine level and to a 57 - and 15-fold increase in histamine content in the membranous and glandular regions of the rat stomach, respectively. Infection of rats with Trypanosoma cruzi also induced a 2- and 4-fold increase in mast cell numbers in the membranous and glandular regions of the muscle layer of the gastric wall, respectively, and a ganglionic inflammatory reaction with predominance of mononuclear cells. We conclude that in acutely Trypanosoma cruzi-infected rats, the reduction of acetylcholine content is due to gastric denervation and that the histamine increase might be secondary to gastric denervation and/or to an increase in the number of mast cells of the gastric wall


Asunto(s)
Ratas , Animales , Masculino , Acetilcolina/metabolismo , Enfermedad de Chagas/metabolismo , Estómago/metabolismo , Histamina/metabolismo , Acetilcolina/análisis , Estómago/patología , Histamina/análisis , Mastocitos/análisis , Mastocitos/fisiología , Plexo Mientérico/patología , Ratas Endogámicas
18.
Arq Neuropsiquiatr ; 46(2): 176-81, 1988 Jun.
Artículo en Portugués | MEDLINE | ID: mdl-3202715

RESUMEN

An autopsied case of multiple cerebral tuberculomas with 37 lesions, the one with the greatest number of lesions described in the literature, is reported. The patient was a chronic alcoholic and had generalized tuberculosis. The literature on multiple cerebral tuberculomas is reviewed and the neurological clinical picture presented by the patient and the association between generalized tuberculosis and chronic alcoholism are commented upon.


Asunto(s)
Encefalopatías/patología , Tuberculoma/patología , Alcoholismo/complicaciones , Encéfalo/patología , Encefalopatías/complicaciones , Humanos , Masculino , Persona de Mediana Edad , Tuberculoma/complicaciones
19.
Arq Gastroenterol ; 22(2): 68-73, 1985.
Artículo en Portugués | MEDLINE | ID: mdl-3833131

RESUMEN

Twenty achlorhydric patients and five controls were submitted to gastric endoscopic biopsies in order to study the histological pattern of the gastric mucosa and the number of enterochromaffin (EC) and gastrin (G) cells of the antral mucosa. The histological changes of the oxyntic mucosa of achlorhydric patients were variable being the predominant pattern the severe chronic atrophic gastritis. The antral mucosa was normal in appearance or revealed mild degree of gastritis. In the most achlorhydric patients the antral EC cell number was decreased when compared to the controls and the G cell number were relatively numerous. The results of the present work are suggestive of an increased G:EC cell ratio in achlorhydric patients.


Asunto(s)
Aclorhidria/patología , Sistema Cromafín/patología , Células Enterocromafines/patología , Mucosa Gástrica/patología , Gastritis Atrófica/patología , Gastritis/patología , Recuento de Células , Humanos , Antro Pilórico/patología
20.
Arq Gastroenterol ; 21(3): 116-8, 1984.
Artículo en Portugués | MEDLINE | ID: mdl-6534336

RESUMEN

The distribution of types I and III collagen fibrils was analysed in liver fragments of 18 cases of alcoholic hepatic cirrhosis. Using the method of picrosirius polarization the collagen fibrils type I and III were found to be very increased in both intra and extralobular connective tissue. Type I fibrils were more frequent in the extralobular tissue and type III in the intralobular connective tissue.


Asunto(s)
Colágeno/metabolismo , Cirrosis Hepática Alcohólica/metabolismo , Hígado/patología , Histocitoquímica , Humanos , Microscopía de Polarización
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