Erythrocyte Indices in Patients With Takotsubo Syndrome.

BACKGROUND: Although the prognosis of patients with Takotsubo syndrome (TTS) is relatively favorable, serious complications may occur. This study aimed to investigate the relationship between blood parameters and the occurrence of in-hospital complications. METHODS: Clinical charts of 51 patients with TTS were retrospectively evaluated, and data regarding blood parameters assessed during the first 24 hours of hospitalization were studied. RESULTS: Levels of hemoglobin less than 13 g/dL in men and 12 g/dL in women (P < 0.01), levels of mean corpuscular hemoglobin concentration (MCHC) less than 33 g/dL (P = 0.01), and levels of red blood cell distribution width-coefficient of variation higher than 14.5% (P = 0.01) were significantly associated to the occurrence of major adverse cardiovascular events (MACE). Markers, such as, platelets to lymphocytes ratio, lymphocytes to monocytes ratio, neutrophils to lymphocytes ratio, and white blood cell count to mean platelet volume, were unable to differentiate patients with and without complications (P > 0.05). MCHC and estimated glomerular filtration rate were independent predictors of MACE. CONCLUSIONS: Blood parameters may have a role in the stratification risk of patients with TTS. Patients showing low levels of MCHC and decreased estimated glomerular filtration rate were more likely to have in-hospital MACE. This should encourage physicians to closely monitor blood parameters in patients with TTS.

Effects of green tea catechins and exercise training on body composition parameters.

The impact of phytochemicals, as green tea catechins, on body composition measures has become a relevant topic as ongoing epidemiological evidence suggests their potential role in weight loss. Although catechins have been shown to modulate fat and energy metabolism, clinical effects of green tea consumption still remain controversial. Given the role played by physical exercise in weight management, it is important to determine whether the association of catechins and exercise is able to improve outcomes over and above the beneficial effects of exercise alone. Considering that scientific findings on this topic are not entirely consistent, aim of the present review was to assess the current scientific literature regarding the interplay between green tea catechins and exercise in overweight and obese populations. In particular, it was evaluated whether the addition of green tea supplementation to exercise training was able to further improve the exercise-induced changes in body composition parameters.

Can the 20 and 60 s All-Out Test Predict the 2000 m Indoor Rowing Performance in Athletes?

Purpose: The purpose of this study was to look for a new, simple, and fast method of assessing and monitoring indoor race performance and to assess the relationship between 20 s, 60 s, and 2000 m indoor rowing performances of youth rowers to evaluate their anaerobic profile. Methods: For three consecutive days, 17 young able-bodied male rowers (15.8 ± 2.0 years), performed three tests (20 s, 60 s, and 2000 m) on a rowing ergometer. Mean power (W20, W60, and W2000) and 2000 m time (t2000) were considered for the analysis. In addition, 14 athletes (15-18 years) performed a 20 s, 60 s, and 2000 m tests and used this as a control group. To define the anaerobic profile of the athletes, W20 and W60 were normalized as percentages of W2000. Associations between variables were determined by means of the Pearson correlation coefficient (r). Results: Mean power decreased with increasing test duration (W20 = 525.1 ± 113.7 W; W60 = 476.1 ± 91.0 W; W2000=312.9 ± 56.0 W) and negative correlations emerged between t2000 (418.5 ± 23.1 s) and W20 (r = -0.952, p < 0.0001) and W60 (r = -0.930, p < 0.0001). Conclusion: These findings indicate that W20 and W60 are significant predictors of 2000 m rowing ergometer performances. Furthermore, normalized W20 and W60 can be used to evaluate athletes and as a reference for planning anaerobic training sessions, on a rowing ergometer.

Extreme duration exercise affects old and younger men differently.

AIM & METHODS: Extreme endurance exercise provides a valuable research model for understanding the adaptive metabolic response of older and younger individuals to intense physical activity. Here, we compare a wide range of metabolic and physiologic parameters in two cohorts of seven trained men, age 30 ± 5 years or age 65 ± 6 years, before and after the participants travelled ≈3000 km by bicycle over 15 days. RESULTS: Over the 15-day exercise intervention, participants lost 2-3 kg fat mass with no significant change in body weight. V̇O2 max did not change in younger cyclists, but decreased (p = 0.06) in the older cohort. The resting plasma FFA concentration decreased markedly in both groups, and plasma glucose increased in the younger group. In the older cohort, plasma LDL-cholesterol and plasma triglyceride decreased. In skeletal muscle, fat transporters CD36 and FABPm remained unchanged. The glucose handling proteins GLUT4 and SNAP23 increased in both groups. Mitochondrial ROS production decreased in both groups, and ADP sensitivity increased in skeletal muscle in the older but not in the younger cohort. CONCLUSION: In summary, these data suggest that older but not younger individuals experience a negative adaptive response affecting cardiovascular function in response to extreme endurance exercise, while a positive response to the same exercise intervention is observed in peripheral tissues in younger and older men. The results also suggest that the adaptive thresholds differ in younger and old men, and this difference primarily affects central cardiovascular functions in older men after extreme endurance exercise.

Redox and autonomic responses to acute exercise-post recovery following Opuntia ficus-indica juice intake in physically active women.

BACKGROUND: The aim of this study was to investigate if the supplementation with Opuntia ficus-indica (OFI) juice may affect plasma redox balance and heart rate variability (HRV) parameters following a maximal effort test, in young physically active women. METHODS: A randomized, double blind, placebo controlled and crossover study comprising eight women (23.25 ± 2.95 years, 54.13 ± 9.05 kg, 157.75 ± 0.66 cm and BMI of 21.69 ± 0.66 kg/m2) was carried out. A juice containing OFI diluted in water and a Placebo solution were supplied (170 ml; OFI = 50 ml of OFI juice + 120 ml of water; Placebo = 170 ml beverage without Vitamin C and indicaxanthin). Participants consumed the OFI juice or Placebo beverage every day for 3 days, before performing a maximal cycle ergometer test, and for 2 consecutive days after the test. Plasma hydroperoxides and total antioxidant capacity (PAT), Skin Carotenoid Score (SCS) and HRV variables (LF, HF, LF/HF and rMSSD) were recorded at different time points. RESULTS: The OFI group showed significantly lower levels of hydroperoxides compared to the Placebo group in pre-test, post-test and 48-h post-test. PAT values of the OFI group significantly increased compared to those of the Placebo group in pre-test and 48-h post-test. SCS did not differ between groups. LF was significantly lower in the OFI group 24-h after the end of the test, whereas rMSSD was significantly higher in the OFI group 48-h post-test. CONCLUSION: OFI supplementation decreased the oxidative stress induced by intense exercise and improved autonomic balance in physically active women.

Association between Tpeak-Tend/QT and major adverse cardiovascular events in patients with Takotsubo syndrome.

BACKGROUND: Conflicting results have been described in the scientific literature regarding the relationship between electrocardiographic parameters and complications in patients with Takotsubo syndrome (TTS). Aim of the present study was to investigate whether there is an association between markers of ventricular repolarization and major adverse cardiovascular events (MACE) during hospitalisation. METHODS: A retrospective chart review was conducted on a sample of patients with diagnosis of TTS, based on the fulfilment of the revised Mayo Clinic criteria. MACE included acute heart failure, cardiogenic shock, sustained ventricular tachycardia, ventricular fibrillation, and death. The following parameters, assessed on the admission electrocardiogram, were analysed: ST-segment elevation, ST-segment depression, T wave inversion, presence of Q waves, QT interval, QT interval corrected for heart rate, QT-dispersion, Tpeak-Tend (Tpe) interval, Tpe dispersion, Tpe/QT ratio, and QTpeak/QT ratio. RESULTS: Patients with MACE, compared to patients without MACE, showed more commonly anterior ST-segment elevation and had significantly higher values of Tpe/QT ratio. Low ejection fraction and Tpe/QT ratio > 0.27 identified a sub-population of patients more likely to have MACE during hospitalisation. CONCLUSIONS: Tpe/QT ratio represents a useful electrocardiographic parameter in the acute phase of TTS.

Predicting the 2000-m Rowing Ergometer Performance from Anthropometric, Maximal Oxygen Uptake and 60-s Mean Power Variables in National Level Young Rowers.

Many studies reported various relationships between 2000-m rowing performance and anthropometric as well as metabolic variables, however, little is known about 60-s mean power in elite youth athletes. The aim of this study was to develop different regression models to predict 2000-m rowing indoor performance time (t2000) using anthropometric variables, maximal oxygen uptake (VO2max) and mean power established during a 60-s all-out test (W60) in national elite youth rowers. Fifteen youth male Italian rowers (age: 15.7 ± 2.0 years; body height: 176.0 ± 8.0 cm; body mass: 71.2 ± 10.0 kg) performed an incremental maximal test, a 60-s all-out test and a 2000-m race simulation using a Concept2 rowing ergometer to assess VO2max, W60 and t2000, respectively. The relationships of all variables with t2000 were investigated through Pearson's correlation. Multiple regression analyses were used to verify the best prediction model of 2000-m indoor rowing performance. The reliability of these models was expressed by R2 and the standard error of estimate. The results showed that t2000 was significantly correlated with all the examined variables, except for VO2max/body mass and age, and exhibited the significantly highest relationship with W60 (r = -0.943). The combination of anthropometric, VO2max and W60 variables was found to be the most reliable equation to predict t2000 (R2 = 0.94, SEE = 6.4). W60 measure should be considered when monitoring the rower's capability to perform high-intensity phases, important during the race's fast start and end. Not requiring expensive equipment and long duration, a 60-s all-out test could be considered a valuable tool for predicting 2000-m performance of elite youth rowers.

Race Profiles of Rowers During the 2014 Youth Olympic Games.

Cerasola, D, Cataldo, A, Bellafiore, M, Traina, M, Palma, A, Bianco, A, and Capranica, L. Race profiles of rowers during the 2014 Youth Olympic Games. J Strength Cond Res 32(7): 2055-2060, 2018-Among the different factors affecting the outcome of elite rowing competitions, pacing strategy plays a relevant role. The purpose of this study was to analyze the race profiles of youth athletes competing at the 2014 Youth Olympic Games over a distance of 1,000 m. According to the competition outcome of sculling and sweep events, 96 youth (17-18 years) rowers (48 male and 48 female) were divided into winner (W), not winner (NW), qualified (Q), and not-qualified (NQ) athletes. The time during the 1,000-m race distance was considered at 0-500 m (T1) and 500-1000 m (T2). The average speed of T1 and T2 were normalized in relation to the average speed of the whole race. In both sexes, W rowers showed higher (p > 0.05) T2 values (100.8 ± 0.9%) with respect to T1 (99.2 ± 0.9%) ones. Female athletes showed a higher (p ≤ 0.05) T1 with respect to T2 in NW, Q, and NQ, whereas male athletes exhibited a higher T1 (p ≤ 0.05) than T2 speed only in NQ. While to be admitted to the final phase of the competition, the rowers tended to favor a positive race strategy (88%); during the final phase, a difference (p = 0.43) emerged for outcome, with the majority of medalists (67%) adopting a negative race strategy. These results suggest that winners have applied a different race strategy compared with the other groups in consequence to a higher efficiency of anaerobic metabolism.

Resting sympatho-vagal balance is related to 10 km running performance in master endurance athletes.

Relationships between heart rate recovery after exercise (HRR, baseline heart rate variability measures (HRV), and time to perform a 10Km running trial (t10Km) were evaluated in "master" athletes of endurance to assess whether the measured indexes may be useful for monitoring the training status of the athletes. Ten "master" athletes of endurance, aged 40-60 years, were recruited. After baseline measures of HRV, the athletes performed a graded maximal test on treadmill and HRR was measured at 1 and 2 minutes from recovery. Subsequently they performed a 10Km running trial and t10Km was related to HRV and HRR indexes. The time to perform a 10Km running trial was significantly correlated with baseline HRV indexes. No correlation was found between t10Km and HRR. Baseline HRV measures, but not HRR, were significantly correlated with the time of performance on 10km running in "master" athletes. The enhanced parasympathetic function at rest appears to be a condition to a better performance on 10km running. HRV can be simple and useful measurements for monitoring the training stratus of athletes and their physical condition in proximity of a competition.

The influence of the stomatognathic system on explosive strength: a pilot study.

[Purpose] Recent findings suggest there is an interesting interaction between the stomatognathic system and the musculoskeletal system. The aim of this study was therefore to examine the influence of the temporomandibular joint on the explosive strength of the lower limbs. [Subjects and Methods] An observational study was carried out. The subjects were 60 male football players who voluntarily participated in the investigation. After a warm-up phase of 10 minutes, each participant performed three Squat Jumps (SJ) with different mandible positions: mouth closed and mouth open. SJ heights were recorded using a Sensor Medica force platform and the FreeMed system. [Results] Sixty participants were enrolled in this study (age: 24 ± 7 yrs; height: 174 ± 4.6 cm; weight 63.7 ± 7.6 kg). The SJ heights with the mouth closed, 38.50 ± 4.0 cm, were shorter than those with the mouth open, 40.4 ± 4.1 cm. Statistical analysis showed there was a statistically significant difference between the performances. [Conclusion] This pilot study highlighted that occlusal factors can influence physical performance and this could have practical applications in sports and exercise science. However, our results have to be confirmed in studies with larger numbers of participants and supported by other investigations.

Influence of baseline heart rate variability on repeated sprint performance in young soccer players.

BACKGROUND: The aim of this study was to assess the influence of the autonomic system on the performance of repeated sprints, involving predominantly neuromuscular power, in young soccer players. METHODS: Twelve young soccer players, selected for the Sicilian Regional Football Representative, mean age 15 years, were recruited. Baseline heart rate variability (HRV) was measured and indices of power spectral analysis (LF, HF, and LF/HF ratio) were calculated to evaluate the sympathovagal balance. The athletes performed 10 maximal 6-second cycling sprints (RS), interspersed with 30 seconds of recovery, to measure the peak power output (PP) represented by the highest power value recorded during a 6-second sprint, and the mean peak power output (MPP) represented by the average of all highest power values recorded within a repeated-sprint bout. RESULTS: PP was negatively correlated with LF (ρ=-0.685, P=0.0141) and LF/HF (ρ=-0.709, P=0.0098), and positively correlated with HF (ρ=0.684, P=0.0142). MPP was negatively correlated with LF (ρ=-0.610, P=0.0350) and LF/HF (ρ=-0.606, P=0.0366), and positively correlated with HF (ρ=0.731, P=0.0070). CONCLUSIONS: Our study shows that a baseline parasympathetic predominance in the autonomic nervous system balance is associated with a better neuromuscular contribution to performance, resulting in higher values of PP and MPP during brief repeated maximal cycling sprints. The assessment of baseline HRV before exercise may be useful for to monitor the physical condition of young soccer players and their readiness status to a higher performance.

Long-Term Structural and Functional Myocardial Adaptations in Healthy Living Kidney Donors: A Pilot Study.

BACKGROUND AND AIMS: Compensatory renal hypertrophy following unilateral nephrectomy (UNX) occurs in the remaining kidney. However, the long-term cardiac adaptive process to UNX remains poorly defined in humans. Our goal was to characterize myocardial structure and function in living kidney donors (LKDs), approximately 12 years after UNX. METHODS AND RESULTS: Cardiac function and structure in 15 Italian LKDs, at least 5 years after UNX (median time from donation = 8.4 years) was investigated and compared to those of age and sex matched U.S. citizens healthy controls (n = 15). Standard and speckle tracking echocardiography (STE) was performed in both LKDs and controls. Plasma angiotensin II, aldosterone, atrial natriuretic peptide (ANP), N terminus pro B-type natriuretic peptide (NT-proBNP), cyclic guanylyl monophosphate (cGMP), and amino-terminal peptide of procollagen III (PIIINP) were also collected. Median follow-up was 11.9 years. In LKDs, LV geometry and function by STE were similar to controls, wall thickness and volumes were within normal limits also by CMR. In LKDs, CMR was negative for myocardial fibrosis, but apical rotation and LV torsion obtained by STE were impaired as compared to controls (21.4 ± 7.8 vs 32.7 ± 8.9 degrees, p = 0.04). Serum creatinine and PIIINP levels were increased [1.1 (0.9-1.3) mg/dL, and 5.8 (5.4-7.6)] µg/L, respectively), while urinary cGMP was reduced [270 (250-355) vs 581 (437-698) pmol/mL] in LKDs. No LKD developed cardiovascular or renal events during follow-up. CONCLUSIONS: Long-term kidney donors have no apparent structural myocardial abnormalities as assessed by contrast enhanced CMR. However, myocardial deformation of the apical segments, as well as apical rotation, and LV torsion are reduced. The concomitant increase in circulating PIIINP level is suggestive of fibrosis. Further studies, focused on US and EU patients are warranted to evaluate whether these early functional modifications will progress to a more compromised cardiac function and structure at a later time.

PPARα gene variants as predicted performance-enhancing polymorphisms in professional Italian soccer players.

BACKGROUND: The PPARα gene encodes the peroxisome proliferator-activator receptor alpha, a central regulator of expression of other genes involved in fatty acid metabolism. The purpose of this study was to determine the prevalence of G allele of the PPARα intron 7 G/C polymorphism (rs4253778) in professional Italian soccer players. METHODS: Sixty professional soccer players and 30 sedentary volunteers were enrolled in the study. Samples of venous blood were obtained at rest, in the morning, by conventional clinical procedures; blood serum was collected and total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides were measured. An aliquot of anticoagulant-treated blood was used to prepare genomic DNA from whole blood. The G/C polymorphic site in PPARα intron 7 was scanned by using the PCR-RFLP (polymerase chain reaction restriction fragment length polymorphism) protocol with TaqI enzyme. RESULTS: We found variations in genotype distribution of PPARα polymorphism between professional soccer players and sedentary volunteers. Particularly, G alleles and the GG genotype were significantly more frequent in soccer players compared with healthy controls (64% versus 48%). No significant correlations were found between lipid profile and genotype background. CONCLUSION: Previous results demonstrated an association of intron 7 G allele as well as the GG genotype in endurance athletes. Our result suggests that this is the case also in professional soccer players.

Soccer players have a better standing balance in nondominant one-legged stance.

The purpose of this study was to analyze the differences in standing balance during dominant and nondominant one-legged stance among athletes of different sports and sedentary subjects. The right-footed subjects of four groups (sedentary, n = 20; soccer, n = 20; basketball, n = 20; windsurfer n = 20) underwent 5-sec unipedal (left and right foot) stabilometric analysis with open eyes and closed eyes to measure center of pressure (COP) sway path and COP velocity (mean value, anteroposterior, and laterolateral in millimeters per second). The soccer group showed better standing balance on the left leg than the sedentary group (P < 0.05). No other significant differences were observed within and amongst groups. The soccer players have a better standing balance on the nondominant leg because of soccer activity.

Family history, diabetes and extension of coronary atherosclerosis are strong predictors of adverse events after PTCA: A one-year follow-up study.

BACKGROUND AND AIM: In this study we addressed some open questions in patients with coronary artery disease (CAD). First, we analysed which of the traditional risk factors was associated with the spreading of coronary stenosis and second, we aimed to identify if any variable was predictive of post-percutaneous transluminal coronary angioplasty (PTCA) clinical events. METHODS AND RESULTS: We collected a consecutive series of patients with CAD (n=301) and in the subgroup of patients undergoing PTCA (n=135) we performed a prospective one-year follow-up study recording cardiovascular morbidity and total mortality. According to the extension of coronary atherosclerosis, we found a significant relationship with the prevalence of diabetes in men and with plasma HDL-cholesterol concentrations in women. The follow-up was completed in 95% of patients; we did not document any death whereas clinical events were registered in 16% of patients. At univariate analysis, we found that patients with clinical events had a higher prevalence of family history of CAD (43% vs 14%, p<0.005), diabetes (52% vs 21%, p<0.005) and multivessel disease (52% vs 35%, p<0.05). Multivariate analysis (logistic regression) confirmed that family history of CAD (OR 4.6, 95% CI 1.7-12.8, p<0.005), diabetes (OR 4.0, 95% CI 1.5-10.6, p<0.01) and multivessel disease (OR 2.8, 95% CI 1.1-7.4, p<0.05) were the only variables predictive of clinical events. CONCLUSIONS: In this study, factors associated with the spreading of coronary stenosis were different according to the gender. Moreover, the presence of diabetes and multivessel disease had a negative impact on the long-term prognosis of patients undergoing PTCA. In addition, the family history of CAD represented in our study a strong predictor of clinical events. We suggest that in the management of post-PTCA patients, the role of individual baseline clinical characteristics must be taken into account and that subjects with a family history of premature CAD, diabetes and a wide extension of coronary disease represent those with the highest risk.