RESUMEN
Severe fever with thrombocytopenia syndrome (SFTS), an emerging tick-borne viral disease, is prevalent in East Asia and has also been reported in Southeast Asia since 2019. SFTS patients in Vietnam were first reported in 2019. However, the seroprevalence of severe fever with thrombocytopenia syndrome virus (SFTSV) in Vietnam has not been reported. To investigate the seroprevalence of SFTSV in Vietnam, we collected serum samples from 714 healthy residents in Thua Thien Hue and Quang Nam Province, Vietnam, and the seroprevalence of SFTSV was assessed using immunofluorescence antibody assay (IFA), Enzyme-Linked Immunosorbent Assays (ELISAs) and the 50% focus reduction neutralization test (FRNT50) assay. The seroprevalence of anti-SFTSV IgM or IgG was observed to be 3.64% (26/714), high IgM positivity was >80 (0.28%, 2/714) and the titer of neutralizing antibodies against SFTSV ranged from 15.5 to 55.9. In Pakistan, SFTSV infection confirmed using a microneutralization test (MNT) assay (prevalence is 2.5%) and ELISAs showed a high seroprevalence (46.7%) of SFTSV. Hence, the seroprevalence rate in Vietnam is similar to that in Pakistan and the number of SFTS patients could increase in Vietnam.
Asunto(s)
Infecciones por Bunyaviridae , Phlebovirus , Síndrome de Trombocitopenia Febril Grave , Enfermedades por Picaduras de Garrapatas , Humanos , Estudios Seroepidemiológicos , Vietnam/epidemiología , Anticuerpos Antivirales , Anticuerpos Neutralizantes , Inmunoglobulina M , Inmunoglobulina GRESUMEN
Severe fever with thrombocytopenia syndrome (SFTS), a tickborne viral disease, has been identified in China, South Korea, and Japan since 2009. We found retrospective evidence of SFTS virus (SFTSV) infection in Vietnam, which suggests that SFTSV infections also occur in Vietnam, where the virus has not been known to be endemic.
Asunto(s)
Infecciones por Bunyaviridae/epidemiología , Infecciones por Bunyaviridae/virología , Phlebovirus , Trombocitopenia/epidemiología , Trombocitopenia/virología , Enfermedades por Picaduras de Garrapatas/epidemiología , Enfermedades por Picaduras de Garrapatas/virología , Adulto , Infecciones por Bunyaviridae/diagnóstico , Femenino , Genes Virales , Humanos , Masculino , Phlebovirus/clasificación , Phlebovirus/genética , Phlebovirus/aislamiento & purificación , Filogenia , Vigilancia en Salud Pública , Evaluación de Síntomas , Trombocitopenia/diagnóstico , Enfermedades por Picaduras de Garrapatas/diagnóstico , Vietnam/epidemiologíaRESUMEN
In the study, 30 hepatitis B patients (23 males, 7 females, mean age 33.5 years) treated in Hue Central Hospital and the Hue Medical University Hospital from September 2004 to March 2005 were evaluated to find out the clinical significance of hepatitis B virus genotypes in acute viral hepatitis B. The results: 73.3% of the patients with common jaundice and 26.7% with long-term jaundice. The rate of HBeAg(+) in participants accounted for 43.3%. The rate of HBeAg(+) was similar between male and female. There were 8 patients with genotype B and 4 patients with genotype C. 25% of genotype B patients were female, while all of genotype C patients were male. The genotype C patients had jaundice period lasting more than 4 weeks. 80% of genotype B patients completely recovered and only 50% of patients became chronic disease. 100% of genotype C patients became chronic disease.