Comparative Informativity of Computing Methods of Insulin Resistance Assessment.

We conducted a comparative study of the calculated indices of insulin resistance HOMA-R, Caro, FGIR, and QUICKI in 29 healthy volunteers (mean age 26.21±0.93 years) with normal body mass index (23.34±0.55 kg/m2). Among the used methods for insulin resistance assessment, QUICKI is the only method that has characteristics required for the diagnostic criterium: low variability coefficient, 100% reproducibility, and minimum coefficient of variation.

Pathogenetic Mechanisms of Outbreak and Development of Cardiac Autonomic Neuropathy in Patients with Metabolic Syndrome.

A cross-sectional study of universe sample of patients (N=135; mean age -49.7±0.8 years) with metabolic syndrome yielded the incidence of cardiac autonomic neuropathy of 37.5%. The pathogenetic peculiarities were revealed for the onset and development of this neuropathy. At the early stages, the progress of cardiac autonomic neuropathy closely correlated with elevation of blood glucose, while endothelial dysfunction progressing at the later period against the background of persistent hyperglycemia is viewed as an extra factor contributing to the development of this disease.

Effectiveness of Lifestyle Modification in Corrections of States Associated with Metabolic Syndrome.

In a 3-month study, 30 obese patients were assigned to lifestyle modification therapy, which is the major component of all modern strategies correcting the metabolic syndrome. The 3-month course of non-pharmacological therapy significantly diminished the major index evaluating the state of these patients, i.e., the risk of cardiovascular disasters. This therapy positively affected all the states associated with metabolic syndrome: arterial BP attained the targets in 53% patients together with normalization of their nocturnal arterial BP dipping status; the lipid panel and carbohydrate metabolic indices normalized in 46 and 44% patients, respectively; hepatic steatosis moderated in 56% patients; and the disturbances in hemostasis were annihilated in 67% patients.

Cardiac Autonomic Drive during Arterial Hypertension and Metabolic Disturbances.

ANS support of the cardiac work was assessed with analysis of heart rate variability in representative samples of patients with arterial hypertension and metabolic disturbances manifested by overweight, classes I-II obesity, compromised glucose tolerance, and type II diabetes. Initially enhanced sympathetic effects on the heart rate demonstrated no further increase during the orthostatic test in contrast to suprasegmentary influences enhanced by this test. The pronouncedness of revealed peculiarities in ANS drive to the heart correlated with metabolic disturbances, and these peculiarities attained maximum in patients with type II diabetes.

Role of JNK and Involvement of p53 in Stimulation of Growth Potential Realization of Mesenchymal Precursor Cells by Alkaloid Songorine.

The role of JNK-mediated signal pathway and participation of p53 transcription factor in stimulation of realization of the growth potential of the mesenchymal precursor cells by alkaloid songorine were examined in vitro. Specific inhibitors of JNK and p53 enhanced stimulation of fibroblast colony/cluster formation and proliferative activity of mesenchymal precursor cells. Under these conditions, more pronounced effects were observed with early precursors of fibroblast CFU and in both cases were accompanied by a decrease in differentiation index of progenitor elements.