1.
Acta Biochim Pol
; 38(1): 123-7, 1991.
Artículo
en Inglés
| MEDLINE
| ID: mdl-1796693
RESUMEN
It has been found that the methylcholanthrene-induced rat fibrosarcoma contains an enzyme (probably a cathepsin) which digests type I and type III collagens in acid pH. At physiological pH no proteolytic activity against collagen was found. It may be concluded that the tumour collagen is degraded mainly by the action of cathepsin(s).
Asunto(s)
Catepsinas/metabolismo , Colágeno/metabolismo , Fibrosarcoma/enzimología , Metilcolantreno , Sarcoma Experimental/enzimología , Animales , Catepsinas/aislamiento & purificación , Fibrosarcoma/inducido químicamente , Fibrosarcoma/metabolismo , Concentración de Iones de Hidrógeno , Hidrólisis , Ratas , Sarcoma Experimental/inducido químicamente , Sarcoma Experimental/metabolismo , Viscosidad
2.
Rocz Akad Med Bialymst (1989)
; 35-36: 3-14, 1990.
Artículo
en Polaco
| MEDLINE
| ID: mdl-2136546
RESUMEN
Rat fibrosarcoma induced by methylcholanthrene exhibited proteolytic activity against type I collagen at acidic range of pH values. This activity was not only collagen-specific as it was able to cause hemoglobin degradation to low-molecular products. No collagenolytic activity was found near physiological values pH.
