[Changes in the level of DNA minor bases in salivary gland inflammation and its correction with antioxidants]. / Izmenenie soderzhaniia minornykh osnovanii DNK pri vospalenii sliunnoi zhelezy i ego korrektsiia antioksidantami.

In the experiment with guinea pigs at contact sialoadenitis reproduction (karragenine inflammation of soft tissues of the oral cavity) it was established that in DNA of salivary glands cells and the neighbouring tissues the content of 5-methylcytosine was decreased, it being normalized at "Triovit" antioxidant complex together with cvercitynum correction. The content of DNA 8-hydroxyguanine is characterized by a wide range of data and in absolute values increases in inflammation, but decreases after antioxidant correction. The role of the changes discovered is discussed.

[The sources of active forms of oxygen in the normal oral tissues and in pathology]. / Istochniki aktivnykh form kisloroda v tkaniakh rotovoi polosti v norme i pri patologii.

In the experiment on rats the changes of the superoxydanionradical production from microsomal and mitochondrial oxidation and tissue phagocytes of the saliva gland and parodontium in contact sialadenitis, spontaneous parodontitis, after ionizing radiation have been investigated. It is supposed that an increase or decrease of superoxydanionradical production from different sources demands a differentiated corrective approach.

[The antioxidant system of patients with chronic inflammatory liver diseases after exposure to ionizing radiation]. / Antioksidantnaia sistema bol'nykh khronicheskimi vospalitel'nymi zabolevaniiami pecheni posle vozdeistviia ioniziruiushchego izlucheniia.

Commonly seen in liquidators of the effects of the Chernobyl accident are affections of the liver (chronic hepatitis) and bile tract (chronic calculous cholecystitis) accompanied by IHD. The above patients demonstrate enhancement of the antioxidant defence in the blood with the values for free-radical peroxidation remaining unchanged. Absolute values for blood content of LTV4 in chronic active hepatitis were found out to be low, which fact suggests that such patients need to be kept under periodic oncological surveillance.

[Antioxidant status in manganese poisoning]. / Antioksidantnyi status pri margantsevoi intoksikatsii organizma.

Pigs intoxication by chloride manganese in dose 50 mg/kg perk day for 10 days brings to lowering antioxidant protection in blood and the level of respiratory neutrophils' burst. In liver and kidneys superoxide dismutase activity increases, in liver--increasing of initiate and final malondialdehyde contents and lowering of concentration of restored glutathione and ATP.

[The mechanisms of the action of fluorine on periodontal tissues]. / Mekhanizmy deistviia ftora na tkani parodonta.

It is stated that fluoride intoxication promotes a sharp intensification of the peroxidation processes in the parodontium tissues. It is caused by a respirator explosion of neutrophils, a decrease in activity of antioxidant system enzymes, thus leading to disturbances of microcirculation and blood coagulation, ischemia development. The last factor can retard the enzymatic oxidation in a cell due to hypoxia, injures lysosomal membranes promoting partial autolysis of parodontium tissues, cell structures, intercellular substance. The interaction of blood with destructive elements of cells and collagen favours the development of trombohemorrhagic reactions in the parodontium tissues. A generalized damage of parodontium arises which intensifies under the effect of any other pathogenetic factors.

[The adrenergic mechanisms of the inhibition of the gastric acid-forming function in acute stress]. / Adrenergicheskie mekhanizmy tormozheniia kislotoobrazuiushchei funktsii zheludka pri ostrom stresse.

It was demonstrated in experiments on Wistar rats that blockade of central adrenergic structures by thymopentin and beta-adrenergic receptors by inderal prevents stress inhibition of hydrochloric acid secretion. Normalization of the antioxidative protection of the stomach which prevents activation of the processes of free-radical oxidation in it plays an essential role in the mechanism of the stress-protective effect of adrenergic influences blockade on the gastric acid-producing function.

[Effect of neutrophils on the state of lipid peroxidation in the erythrocytes and its physiological significance]. / Vliianie neitrofil'nykh leikotsitov na sostoianie lipidnoi peroksidatsii v éritrotsitakh i ego fiziologicheskoe znachenie.

Theoretical grounds of the existence (in the organism) of physiological process of the neutrophil granulocyte-erythrocyte interaction are presented. This process underlies damage and destruction of old erythrocytes. A conclusion is made concerning the peroxide mechanism of this interaction. This process possibly takes place under physiological conditions and becomes more pronounced after splenectomy .

[Reaction of the salivary glands to acute stress]. / Reaktsiia sliunnykh zhelez na ostryi stress.

Experiment on male rats has shown that acute stress suppressed amylase and superoxide dismutase activity in the submandibular salivary glands. The influence of short repeated stresses weakened the inhibiting effect of the acute stress on the activity of enzymes. A conclusion is drawn about the high sensibility of salivary glands to stress influences.

[Characteristic of gastric response to acute and chronic stress and to their combination]. / Osobennosti reaktsii zheludka na ostryi i khronicheskii stressy, a takzhe na ikh sochetanie.

Experiments on 39 rats subjected to the effect of acute, chronic stresses and to that of their combination have revealed a parallelism between the degree of the ulcerogenic effect and depression of antioxidant activity of the stomach tissue cells.

[The protective action of thymopentin on stress damage to the stomach]. / Zashchitnoe deistvie timopentina na stressornoe povrezhdenie zheludka.

The influence of peptide thymopentin on ulcer effects of the stomach mucous membrane in rats and the state of its processes in acute and chronic stress as well as their combination influence were investigated. The intercommunication of frequency of the formation of ulcer and the activity of superoxide dismutase in stomach fibers was established. Thymopentin displayed a marked antiulcerogenic effect in all kinds of stress.