RESUMEN
In experiments on 33 albino male rats it was established that during allyl alcohol-induced damage of the liver its excretory function is impaired that was judged by the biliary excretion of intravenously injected Bengal pink-131I. Antioxidants (tocopherol acetate, sodium selenite, unithiol) reduced the toxic effect of allyl alcohol on the liver.
Asunto(s)
Antioxidantes/uso terapéutico , Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico , Hígado/efectos de los fármacos , Propanoles , 1-Propanol/toxicidad , Animales , Enfermedad Hepática Inducida por Sustancias y Drogas/diagnóstico por imagen , Enfermedad Hepática Inducida por Sustancias y Drogas/fisiopatología , Evaluación Preclínica de Medicamentos , Radioisótopos de Yodo , Hígado/diagnóstico por imagen , Hígado/fisiopatología , Masculino , Cintigrafía , Ratas , Rosa Bengala , Factores de TiempoRESUMEN
It was shown on pubertal albino rats that the intensity of excretion with the bile of radioactive Bengal rose was different at different seasons: the maximum and minimum levels were observed in winter and summer, respectively. When the liver was affected with tetracycline, this process was suppressed especially in summer. The use of antioxidants, such as tocopherol acetate in combination with sodium selenite promoted the recovery of liver excretion function in winter, spring and autumn. In summer, the recovery was only partial.