RESUMEN
A 60-year-old woman was diagnosed with cT4N3M1c stage IVB lung adenocarcinoma with epidermal growth factor receptor mutation of exon19 deletion. After one month of treatment with osimertinib, a cough and diffuse ground glass opacities were observed in the bilateral lung field. Based on the clinical course and the exclusion of other etiologies, osimertinib-induced pneumonitis was diagnosed. The shadows resolved after osimertinib was discontinued. However, brain metastasis and leptomeningeal metastasis developed 20 months later; therefore, osimertinib was re-administered without concomitant corticosteroids. The pulmonary lesion and leptomeningeal metastasis were successfully treated without recurrence of drug-induced pneumonitis for eight months.
RESUMEN
The Cobb's and Ferguson's methods are widely used in order to measure scoliotic angle using the X-ray photograph. Since the scoliotic angle is detected on the bases of the positions of only two and three spines, the measured value includes various kinds of errors. Thus, the present study was designed to examine accuracy and reliability of the Cobb's and Ferguson's methods. The scoliotic angle corresponding to the Cobb's and Ferguson's method were computed using the least square approximating curve that was obtained on the basis of the positions of spines from thoracic to lumbar vertebrae.<BR>As a result, it was found that the scoliotic angle by means of the clinical Cobb's method was closely correlated to that by the least square method with positive correlation coefficient of 0.98. On the other hands, the Ferguson's method showed less relation to the least square method. Thus, it was confirmed that the Cobb's method was more reliable for diagonsis of the scoliosis.