[A case of ovarian cancer in which a remarkable effect was seen with intrathoracic administration of CDDP and CPT-11].

A-58-year-old female admitted to our hospital for abdominal fullness and dyspnea was diagnosed with malignant pleuro-peritonitis of advanced ovarian cancer. CT showed a massive right-sided pleural effusion, massive ascites, and large ovarian tumor (about 10 x 15 cm). The patient was treated with intrathoracic administration of CDDP and CPT-11. Combination chemotherapy of CDDP (10 mg/week) and CPT-11 (10 mg/week) was administered by intrapleural injection every other week. As a result (total amount; CDDP 310 mg, CPT-11 250 mg, in 9 months), pleural effusion and ascites disappeared. Moreover, marked shrinkage (about 3 x 4 cm) of the tumor was confirmed. This intrathoracic administration of CDDP and CPT-11 may be an effective loco-regional therapy for advanced ovarian cancer with malignant pleuro-peritonitis.

[A case of advanced pancreatic cancer treated successfully with self-expandable stent, PTEG and chemotherapy].

A 52-year-old male admitted to our hospital for ileus was diagnosed with advanced pancreatic cancer. He was complicated with multiple alimentary tract stenosis (duodenal third portion, ascending portion and splenic-flexure portion of colon) due to intraabdominal spread of malignancies. The self-expandable metal stent was successfully placed in each stenotic portion with being effectively decompressed of his intestinal obstruction by the procedure of percutaneous transesophageal gastro-tubing (PTEG). These treatments improved his symptoms to ingest orally in addition to the tube feeding per PTEG. Furthermore, he has been receiving adjuvant chemotherapy with GEM, S-1, and CPT-11 for 9 months at outpatient department. We concluded a combined procedure of self-expandable stent and PTEG was useful palliative treatment in malignant gastrointestinal obstruction of advanced pancreatic cancer.