RESUMEN
A retrospective analysis was made of 541 case reports of patients with coronary heart disease admitted to the infectious department with the diagnosis of influenza (n-387) and parainfluenza (n-154). In all the patients, the diagnosis was verified serologically with the aid of the hemagglutination inhibition test, with a 4-fold and greater increase of the antibody titer in the serum. In part of the patients, it was confirmed by the above test combined with immunofluorescence in examining rhinopharyngeal smears and in part of influenza patients, it was verified virologically. Exacerbation of CHD was seen in the period of early convalescence in 60% of cases whatever the etiology of viral infection (days 5-13 of the disease). As compared to parainfluenza, influenza provoked the deterioration of CHD significantly more often, especially influenza B (25 and 14.3%). The group at risk for an unfavourable outcome of CHD included patients with influenza and parainfluenza, suffering from postinfarction cardiosclerosis. In this group, exacerbation of CHD was diagnosed in 38.3 and 26.1% of cases, whereas acute myocardial infarction developed in 11.7 and 4.4% of cases. Every second influenza patient and every third parainfluenza patient with acute pneumonia and postinfarction cardiosclerosis demonstrated deterioration of CHD.
Asunto(s)
Virus de la Influenza A , Virus de la Influenza B , Gripe Humana/etiología , Isquemia Miocárdica/complicaciones , Virus de la Parainfluenza 1 Humana , Virus de la Parainfluenza 3 Humana , Infecciones por Paramyxoviridae/etiología , Enfermedad Aguda , Factores de Edad , Humanos , Gripe Humana/diagnóstico , Gripe Humana/epidemiología , Isquemia Miocárdica/diagnóstico , Isquemia Miocárdica/epidemiología , Virus de la Parainfluenza 2 Humana , Infecciones por Paramyxoviridae/diagnóstico , Infecciones por Paramyxoviridae/epidemiología , Estudios Retrospectivos , Factores SexualesRESUMEN
A retrospective analysis was made of the case reports of 829 patients admitted to the infectious department with a diagnosis of influenza (592) and parainfluenza (237). In all the patients, the diagnosis was supported serologically with the aid of the hemagglutination inhibition test, with the antibody titer in the serum rising 4-fold and more. In part of the patients the indicated test was used in combination with the immunofluorescence test in studying nasopharyngeal smears, whereas in part of the patients, it was coupled with virological tests. It has been revealed that in addition to the most frequently occurring complications on the part of the bronchopulmonary system and ENT organs caused by the pneumococcal and streptococcal flora, there were complications on the part of the endocrine, urogenital, nervous and gastrointestinal systems, equally in patients with influenza and parainfluenza. In patients with postinfarction cardiosclerosis, influenza B and mixed influenza run the most unfavourable course, provoking deterioration of coronary heart disease in every other patient. In 66.6% of cases, exacerbation of coronary heart disease fell within the period of early convalescence of patients with influenza and parainfluenza.
Asunto(s)
Enfermedad Crónica/epidemiología , Hospitalización/estadística & datos numéricos , Virus de la Influenza A , Virus de la Influenza B , Gripe Humana/complicaciones , Virus de la Parainfluenza 1 Humana , Virus de la Parainfluenza 2 Humana , Virus de la Parainfluenza 3 Humana , Infecciones por Paramyxoviridae/complicaciones , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Incidencia , Gripe Humana/epidemiología , Masculino , Persona de Mediana Edad , Infecciones por Paramyxoviridae/epidemiología , Estudios Retrospectivos , U.R.S.S./epidemiologíaRESUMEN
The relationship between the elimination of shigellae from the body with urine and the dynamics of morphological changes in the mucous membrane of the large intestine of acute dysentery patients at the early convalescence period has been studied. The persistence of Shigella antigen in acute dysentery patients and its elimination with urine is, as a rule, accompanied by local immune cell reaction in the mucous membrane of the large intestine. The antigen circulating in the body is a factor contributing to the inflammatory process in the intestine, the amount of the eliminated antigen being higher in pronounced inflammations of the intestinal mucosa than in residual inflammatory phenomena. A group of patients (3 persons) releasing Shigella O-antigen with urine and having the inflammatory process in the large intestine, but showing no signs of local immune reaction in the lymphoid tissue of the large intestine, has been found. The reactivity of the lymphoid tissue of the intestine in such patients is a risk factor contributing to the development of prolonged dysentery or chronic postdysenteric colitis.
Asunto(s)
Antígenos Bacterianos/orina , Disentería Bacilar/orina , Mucosa Intestinal/inmunología , Enfermedad Aguda , Adolescente , Adulto , Disentería Bacilar/inmunología , Humanos , Intestino Grueso/inmunología , Tejido Linfoide/inmunología , Masculino , Persona de Mediana EdadAsunto(s)
Infecciones Meningocócicas/diagnóstico , Neisseria meningitidis/clasificación , Adolescente , Adulto , Femenino , Humanos , Masculino , Meningitis Meningocócica/diagnóstico , Meningitis Meningocócica/microbiología , Infecciones Meningocócicas/microbiología , Meningoencefalitis/diagnóstico , Meningoencefalitis/microbiología , Sepsis/diagnóstico , Sepsis/microbiología , SerotipificaciónAsunto(s)
Antibacterianos/uso terapéutico , Heces/inmunología , Inmunoglobulinas/aislamiento & purificación , Intoxicación Alimentaria por Salmonella/inmunología , Adolescente , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Intoxicación Alimentaria por Salmonella/tratamiento farmacológicoAsunto(s)
Disentería Bacilar/tratamiento farmacológico , Furazolidona/uso terapéutico , Tetraciclina/uso terapéutico , Enfermedad Aguda , Adenilil Ciclasas/sangre , Adolescente , Adulto , AMP Cíclico/sangre , GMP Cíclico/sangre , Disentería Bacilar/enzimología , Guanilato Ciclasa/sangre , Humanos , Persona de Mediana EdadAsunto(s)
Colon Sigmoide/patología , Disentería Bacilar/tratamiento farmacológico , Mucosa Intestinal/patología , Recto/patología , Adolescente , Adulto , Anciano , Cloranfenicol/administración & dosificación , Quimioterapia Combinada , Disentería Bacilar/patología , Femenino , Furazolidona/administración & dosificación , Humanos , Masculino , Persona de Mediana Edad , Regeneración , Shigella flexneri , Shigella sonnei , Tetraciclina/administración & dosificaciónAsunto(s)
AMP Cíclico/sangre , GMP Cíclico/sangre , Disentería Bacilar/tratamiento farmacológico , Furazolidona/uso terapéutico , Enfermedad Aguda , Adolescente , Adulto , Antibacterianos/uso terapéutico , Disentería Bacilar/sangre , Femenino , Humanos , Masculino , Persona de Mediana Edad , Shigella flexneri , Shigella sonneiRESUMEN
Comparative study of various methods of treatment was carried out on 777 patients suffering from acute dysentery with a bacteriologically confirmed diagnosis. To assess the therapeutic efficacy, along with consideration of clinical signs of the disease, immunoglobulin level was examined in the blood and coprofiltrates; also the state of reparative processes in the mucosa was appreciated by the histological examination of the biopsy material. Results of the work carried out indicated the inexpediency of the treatment of this disease with a combination of levomycetin and phthalazol. The use of live streptomycin-dependent dysentery vaccine was indicated in protracted torpid dysentery and was of no avail in acute form of the disease. A good therapeutic effect was observed with the application of pathogenetic therapy alone.
Asunto(s)
Cloranfenicol/administración & dosificación , Disentería Bacilar/terapia , Inmunoterapia , Sulfatiazoles/administración & dosificación , Enfermedad Aguda , Cloranfenicol/uso terapéutico , Quimioterapia Combinada , Disentería Bacilar/inmunología , Disentería Bacilar/patología , Heces/inmunología , Humanos , Inmunoglobulina A/análisis , Inmunoglobulina G/análisis , Inmunoglobulina M/análisis , Mucosa Intestinal/patología , Shigella flexneri , Shigella sonnei , Sulfatiazoles/uso terapéuticoRESUMEN
Possible ranges of virulence of Sh. sonnei strains isolated from the patients and carriers in the foci of Sonne dysentery, supposedly with the same source of infection, were studied. Sh. sonnei strains isolated from carriers proved to be less virulent than the strains isolated from patients with the clinical manifestation of the infection. A hypothesis was put forward explaining some aspects of carrier state in Sonne dysentery, which most probably was explained by the refracterity of the macroorganism, not by the alterations in the genom of the causative agent.
Asunto(s)
Disentería Bacilar/microbiología , Shigella sonnei/patogenicidad , Enfermedad Aguda , Animales , Portador Sano/microbiología , Niño , Disentería Bacilar/inmunología , Disentería Bacilar/transmisión , Heces/microbiología , Cobayas , Pruebas de Hemaglutinación , Humanos , Shigella sonnei/aislamiento & purificación , VirulenciaRESUMEN
The analysis of the efficacy of various methods of antibacterial therapy in 1382 patients with obliterated, light and moderately severe forms of dysentery as compared to the patients subjected only to patholgenic therapy showed that broad spectrum antibiotics lost their role in treatment of such patients. Furazolidon proved to be one of the most active drugs. The authors suppose that treatment of patients with obliterated forms of dysentery with antibacterial drugs is not obligatory and is indicated only in cases with repeated isolation of the causative agent.
Asunto(s)
Antibacterianos/uso terapéutico , Antiinfecciosos/uso terapéutico , Disentería Bacilar/tratamiento farmacológico , Enfermedad Aguda , Adolescente , Adulto , Anciano , Cloranfenicol/uso terapéutico , Clioquinol/uso terapéutico , Evaluación de Medicamentos , Quimioterapia Combinada , Femenino , Furazolidona/uso terapéutico , Humanos , Masculino , Persona de Mediana Edad , Sulfatiazoles/uso terapéutico , Tetraciclina/uso terapéutico , Factores de TiempoRESUMEN
A possibility was shown of improvement of serological diagnosis of salmonelloses with the aid of polyvalent (complex) and group salmonellosis stable formalinized erythrocytic diagnostic agents. The use of the mentioned preparations for titration of antibodies of different immunochemical nature in the sera of patients suffering from food toxicoinfections permitted to confirm the clinical diagnosis of salmonellosis in about 30% of cases.