RESUMEN
In studies concerning the relation between structure and sweetness in sulfamic acid derivatives, two new sweeteners (VI) and (VIII) were found. Their corresponding sulfochlorides are also unexpectedly sweet-tasting.
Asunto(s)
Ácidos Sulfónicos/síntesis química , Ácidos Sulfónicos/farmacología , Edulcorantes/síntesis química , Fenómenos Químicos , Química , HumanosRESUMEN
The synthesis and pharmacological activity of several adamantane derivatives and analogs of tilorone are described as part of a systematic research on potential antiviral compounds and/or interferon inducers.
Asunto(s)
Amantadina/síntesis química , Antivirales , Fluorenos/síntesis química , Tilorona/síntesis química , Amantadina/análogos & derivados , Amantadina/farmacología , Animales , Inductores de Interferón , Mengovirus/efectos de los fármacos , Ratones , Virus de los Bosques Semliki/efectos de los fármacos , Tilorona/análogos & derivados , Tilorona/farmacologíaRESUMEN
Several derivatives of L-acylamidosuccinanilic acids have been prepared inorder to study the relationship between the chemical structure and the sweetening activity by modifying the amino or the acylamido portions of the molecule. Some synthesized compounds possess a pronounced sweet taste, the L-4'-nitro-(2,2,2-trichloroacetamido)succinanilic acid is the most outstanding compound, being approximately 3000-4500 times as sweet as sucrose.