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1.
Cureus ; 16(6): e61922, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38978878

RESUMEN

BACKGROUND: Savory crispy or fried snack (SCFS), sugary snack (SS), and sugar-sweetened beverage (SSB) consumption are associated with a higher prevalence of obesity and non-communicable diseases. So, we estimated the consumption of SCFS, SS, and SSB among elderly males and females in Bangladesh. We also reported the factors associated with their consumption using data from a nationwide cross-sectional study. METHODS: We interviewed 2,482 (51.52%) elderly males and 2,335 (48.47%) elderly females for the recall for the past seven days on the intake of SCFS, SS, and SSB from 82 randomly selected clusters from rural, non-slum urban, and slum areas in Bangladesh. Sociodemographic and anthropometry data were also collected. RESULTS: Consumption of SCFS, SS, and SSB for ≥1 time per week was reported by 884 (31.5%), 1,696 (66.1%), and 1,911 (69.3%) of the elderly males and 516 (20.1%), 1,367 (53.9%), and 1,171 (34.1%) of the elderly females, respectively. Both elderly males and females from slum and non-slum urban areas consumed more SSB than their rural counterparts. Higher level of television viewing was associated with increased frequency of intake of SCFS, SS, and SSB among elderly males and SSB intake among elderly females. Nutritional status was not associated with the consumption of these foods and drinks among the elderly; however, overweight males consumed SSB less frequently. CONCLUSION: In Bangladesh, elderly males and females frequently consume unhealthy snacks and drinks. Considering their detrimental effect on health, it is necessary to reduce their consumption through policy and program measures and promote healthier foods and beverages.

2.
PLoS One ; 19(7): e0307565, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39042658

RESUMEN

This manuscript investigates bifurcation, chaos, and stability analysis for a significant model in the research of shallow water waves, known as the second 3D fractional Wazwaz-Benjamin-Bona-Mahony (WBBM) model. The dynamical system for the above-mentioned nonlinear structure is obtained by employing the Galilean transformation to fulfill the research objectives. Subsequent analysis includes planar dynamic systems techniques to investigate bifurcations, chaos, and sensitivities within the model. Our findings reveal diverse features, including quasi-periodic, periodic, and chaotic motion within the governing nonlinear problem. Additionally, diverse soliton structures, like bright solitons, dark solitons, kink waves, and anti-kink waves, are thoroughly explored through visual illustrations. Interestingly, our results highlight the importance of chaos analysis in understanding complex system dynamics, prediction, and stability. Our techniques' efficiency, conciseness, and effectiveness advance our understanding of this model and suggest broader applications for exploring nonlinear systems. In addition to improving our understanding of shallow water nonlinear dynamics, including waveform features, bifurcation analysis, sensitivity, and stability, this study reveals insights into dynamic properties and wave patterns.


Asunto(s)
Dinámicas no Lineales , Modelos Teóricos , Agua/química , Movimientos del Agua , Algoritmos
3.
Sci Rep ; 14(1): 14464, 2024 06 24.
Artículo en Inglés | MEDLINE | ID: mdl-38914575

RESUMEN

This study uses imposed control techniques and vaccination game theory to study disease dynamics with transitory or diminishing immunity. Our model uses the ABC fractional-order derivative mechanism to show the effect of non-pharmaceutical interventions such as personal protection or awareness, quarantine, and isolation to simulate the essential control strategies against an infectious disease spread in an infinite and uniformly distributed population. A comprehensive evolutionary game theory study quantified the significant influence of people's vaccination choices, with government forces participating in vaccination programs to improve obligatory control measures to reduce epidemic spread. This model uses the intervention options described above as a control strategy to reduce disease prevalence in human societies. Again, our simulated results show that a combined control strategy works exquisitely when the disease spreads even faster. A sluggish dissemination rate slows an epidemic outbreak, but modest control techniques can reestablish a disease-free equilibrium. Preventive vaccination regulates the border between the three phases, while personal protection, quarantine, and isolation methods reduce disease transmission in existing places. Thus, successfully combining these three intervention measures reduces epidemic or pandemic size, as represented by line graphs and 3D surface diagrams. For the first time, we use a fractional-order derivate to display the phase-portrayed trajectory graph to show the model's dynamics if immunity wanes at a specific pace, considering various vaccination cost and effectiveness settings.


Asunto(s)
Teoría del Juego , Cuarentena , Humanos , Vacunación , COVID-19/prevención & control , COVID-19/epidemiología , Modelos Teóricos , Control de Enfermedades Transmisibles/métodos , Epidemias/prevención & control
4.
PLoS One ; 19(6): e0304178, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38865370

RESUMEN

This study describes how, as part of the administrative reform of Bangladesh, most of the urban local governments have set up some public service center like Pourasava Digital Center (PDC), where ICT (Information and Communication Technology) has been commonly applied to make e-services more convenient, efficient and transparent. The current study measures the Service Quality Satisfaction and Continuous Use Intention to use Pourasava Digital Center (PDC) in Bangladesh by adopting citizen participation as a moderator. Theoretically, this study has used the DeLone & McLean Information Systems (D&M IS) Success Model and Zhang's two-dimensional satisfaction model. However, most of the existing studies in Bangladesh are qualitative, and the relationship between service quality and citizen satisfaction has not been tested. A survey was conducted based on a structured questionnaire method and data collected from 332 respondents from 05 PDC and applying structural equation modelling in AMOS software while analyzing the data. The empirical results showed that the data fit the model. The finding of this study is that information quality affects specific satisfaction but not accumulative satisfaction, and specific satisfaction might not lead to accumulative satisfaction. One of the worthy findings of this study is that citizen satisfaction is highly dependent on system quality and service quality rather than information quality. The continuous use intention of the citizen is not based on specific satisfaction but significantly depends on accumulative satisfaction. To ensure the improvement of PDC's service quality, all dimensions related to the quality of service should be modified, and the administrative system and citizens should be encouraged to participate in all aspects of services.


Asunto(s)
Participación de la Comunidad , Bangladesh , Humanos , Femenino , Masculino , Encuestas y Cuestionarios , Adulto , Intención , Persona de Mediana Edad , Satisfacción Personal , Comportamiento del Consumidor
5.
Aging Med (Milton) ; 7(2): 239-251, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38725695

RESUMEN

Childhood experiences are known to shape individuals' development and can influence various aspects of life later on. Understanding the long-term effects is crucial for informing interventions and policies aimed at promoting healthy aging. This review aimed to explore the long-term effects of childhood experiences on older individuals. This systematic review comprised three distinct phases. Firstly, a systematic review was conducted, exploring databases such as Google Scholar, PubMed, EMBASE, PsycINFO, and the Web of Science. Out of the 2116 studies initially identified, 24 studies were selected based on the inclusion criteria. Secondly, these inclusion criteria were applied to ensure that the chosen studies specifically delved into the connection between childhood experiences and outcomes in older individuals. Finally, data extraction and synthesis techniques were employed to analyze findings, facilitating the drawing of conclusions concerning the enduring impacts of childhood experiences on the well-being of older individuals. The review's findings revealed how negative experiences in childhood continue to affect older individuals in various ways. These early-life events have far-reaching consequences, profoundly impacting their physical health, making them more susceptible to chronic diseases and weakening their immune system. Additionally, they affect mental health, leading to conditions like depression, anxiety, and substance abuse. Cognitive function is also affected, resulting in memory problems and cognitive decline. Furthermore, these experiences impact social relationships, affecting trust, emotional control, and social isolation in later life. This review highlighted the enduring influence of childhood circumstances on the health and well-being of older individuals. Policymakers and health care practitioners should consider these findings when developing strategies to support healthy aging and mitigate the long-term effects of adverse childhood experiences.

6.
Sci Rep ; 14(1): 11907, 2024 May 24.
Artículo en Inglés | MEDLINE | ID: mdl-38789487

RESUMEN

This research focuses on bifurcation analysis and new waveforms for the first fractional 3D Wazwaz-Benjamin-Bona-Mahony (WBBM) structure, which arises in shallow water waves. The linear stability technique is also employed to assess the stability of the mentioned model. The suggested equation's dynamical system is obtained by applying the Galilean transformation to achieve our goal. Subsequently, bifurcation, chaos, and sensitivity analysis of the mentioned model are conducted by applying the principles of the planar dynamical system. We obtain periodic, quasi-periodic, and chaotic behaviors of the mentioned model. Furthermore, we introduce and delve into diverse solitary wave solutions, encompassing bright soliton, dark soliton, kink wave, periodic waves, and anti-kink waves. These solutions are visually presented through simulations, highlighting their distinct characteristics and existence. The results highlight the effectiveness, brevity, and efficiency of the employed integration methods. They also suggest their applicability to delving into more intricate nonlinear models emerging in modern science and engineering scenarios. The novelty of this research lies in its detailed analysis of the governing model, which provides insights into its complex dynamics and varied wave structures. This study also advances the understanding of nonlinear wave properties in shallow water by combining bifurcation analysis, chaotic behavior, waveform characteristics, and stability assessments.

7.
Data Brief ; 54: 110407, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38708312

RESUMEN

Mathematical entity recognition is essential for machines to define and illustrate mathematical substance faultlessly and to facilitate sufficient mathematical operations and reasoning. As mathematical entity recognition in the Bangla language is novel, to our best knowledge, there is no available dataset exists in any repository. In this paper, we present state of the art Bangla mathematical entity dataset containing 13,717 observations. Each record has a mathematical statement, mathematical type and mathematical entity. This dataset can be utilized to conduct research involving the recognition of mathematical operators, renowned mathematical terms (such as complex numbers, real numbers, prime numbers, etc.), and operands as numbers. The findings mentioned above, and their combination are also feasible with a modest tweak to the dataset. Furthermore, we have structured this dataset in raw format and made a CSV file, incorporating three columns: text, math entity, and label. As an outcome, researchers may easily handle the data, facilitating a variety of deep learning and machine learning explorations.

8.
Heliyon ; 10(5): e26998, 2024 Mar 15.
Artículo en Inglés | MEDLINE | ID: mdl-38495200

RESUMEN

This work concerns the epidemiology of infectious diseases like monkeypox (mpox) in humans and animals. Our models examine transmission scenarios, including transmission dynamics between humans, animals, and both. We approach this using evolutionary game theory, specifically the intervention game-theoretical (IGT) framework, to study how human behavior can mitigate disease transmission without perfect vaccines and treatments. To do this, we use non-pharmaceutical intervention, namely the quarantine policy, which demonstrates the delayed effect of the epidemic. Additionally, we contemplate quarantine-based behavioral intervention policies in deterministic and fractional-order models to show behavioral impact in the context of the memory effect. Firstly, we extensively analyzed the model's positivity and boundness of the solution, reproduction number, disease-free and endemic equilibrium, possible stability, existence, concavity, and Ulam-Hyers stability for the fractional order. Subsequently, we proceeded to present a numerical analysis that effectively illustrates the repercussions of varying quarantine-related factors, information probability, and protection probability. We aimed to comprehensively examine the effects of non-pharmaceutical interventions on disease control, which we conveyed through line graphs and 2D heat maps. Our findings underscored the significant influence of strict quarantine measures and the protection of both humans and animals in mitigating disease outbreaks. These measures not only significantly curtailed the spread of the disease but also delayed the occurrence of the epidemic's peak. Conversely, when quarantine maintenance policies were implemented at lower rates and protection levels diminished, we observed contrasting outcomes that exacerbated the situation. Eventually, our analysis revealed the emergence of animal reservoirs in cases involving disease transmission between humans and animals.

9.
Heliyon ; 10(6): e27716, 2024 Mar 30.
Artículo en Inglés | MEDLINE | ID: mdl-38533022

RESUMEN

The stage of pregnancy is crucial for women of reproductive age and their families. However, in low- and middle-income countries like Bangladesh, antenatal and postnatal care are not widely practiced due to various socio-economic factors, such as low education levels, income, age, pregnancy knowledge, and limited healthcare facilities. The objective of this study was to examine the factors associated with antenatal care in two locations in Bangladesh based on the data collected from the Bangladesh Demographic and Health Survey (BDHS) 2017-2018. We explored different variables as explanatory variables related to ANC service. The results showed that most of the respondents were from rural areas, with 77.02% receiving antenatal care at home. Women with secondary education were more likely to receive care at home than those without education. The Chi-square test indicated a positive correlation between antenatal care at home with several variables, whereas, in the case of Upazila health complexes, only three variables showed a positive association. Logistic regression analysis further showed some specific variables such as geographical division, religion, iron intake during pregnancy, and reporting pregnancy complications had a significant impact on ANC at home. In contrast, covariates such as residence, division, and wealth index were significant for antenatal care at Upazila health complexes. The division was a significant covariate in both cases. Interestingly, we observed that mothers who had been informed about the signs of pregnancy complications were 92% more likely to receive antenatal care at home than those who had not experienced pregnancy complications. Conversely, the results revealed that mothers who were unaware of pregnancy complications were 32% more likely to receive antenatal care at home than those who had been informed about complications. This suggests that when women are educated about pregnancy complications, they are more likely to receive more antenatal care. However, Bangladesh's situation is quite different due to a lack of proper education and knowledge of antenatal care services.

10.
J Health Popul Nutr ; 43(1): 32, 2024 Feb 29.
Artículo en Inglés | MEDLINE | ID: mdl-38424608

RESUMEN

In light of the global prevalence of a highly contagious respiratory disease, this study presents a novel approach to address the pressing and unanticipated issues by introducing a modified vaccination and lockdown-centered epidemic model. The rapid spread of the disease is attributed to viral transmissibility, the emergence of new strains (variants), lack of immunization, and human unawareness. This study aims to provide policymakers with crucial insights for making informed decisions regarding lockdown strategies, vaccine availability, and other control measures. The research adopts three types of models: deterministic, heterogeneous, and fractional-order dynamics, on both theoretical and numerical approaches. The heterogeneous network considers varying connectivity and interaction patterns among individuals, while the ABC fractional-order derivatives analyze the impact of integer-order control in different semi-groups. An extensive theoretical analysis is conducted to validate the proposed model. A comprehensive numerical investigation encompasses deterministic, stochastic, and ABC fractional-order derivatives, considering the combined effects of an effective vaccination program and non-pharmaceutical interventions, such as lockdowns and shutdowns. The findings of this research are expected to be valuable for policymakers in different countries, helping them implement dynamic strategies to control and eradicate the epidemic effectively.


Asunto(s)
Epidemias , Vacunas , Humanos , Epidemias/prevención & control , Vacunación
11.
Sci Rep ; 13(1): 20118, 2023 Nov 17.
Artículo en Inglés | MEDLINE | ID: mdl-37978323

RESUMEN

This paper is primarily concerned with data analysis employing the nonlinear least squares curve fitting method and the mathematical prediction of future population growth in Bangladesh. Available actual and adjusted census data (1974-2022) of the Bangladesh population were applied in the well-known autonomous logistic population growth model and found that all data sets of the logistic (exact), Atangana-Baleanu-Caputo (ABC) fractional-order derivative approach, and logistic multi-scaling approximation fit with good agreement. Again, the existence and uniqueness of the solution for fractional-order and Hyers-Ulam stability have been studied. Generally, the growth rate and maximum environmental support of the population of any country slowly fluctuate with time. Including an approximate closed-form solution in this analysis confers several advantages in assessing population models for single species. Prior studies predominantly employed constant growth rates and carrying capacity, neglecting the investigation of fractional-order methods. Thus, the current study fills a crucial gap in the literature by introducing a more formal approach to analyzing population dynamics. Therefore, we bank on the findings of this article to contribute to accurate population forecasting and planning, national development, and national progress.

12.
PLoS One ; 18(9): e0291071, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37695783

RESUMEN

In this investigation, we apply the improved Kudryashov, the novel Kudryashov, and the unified methods to demonstrate new wave behaviors of the Fokas-Lenells nonlinear waveform arising in birefringent fibers. Through the application of these techniques, we obtain numerous previously unreported novel dynamic optical soliton solutions in mixed hyperbolic, trigonometric, and rational forms of the governing model. These solutions encompass periodic waves with W-shaped profiles, gradually increasing amplitudes, rapidly increasing amplitudes, double-periodic waves, and breather waves with symmetrical or asymmetrical amplitudes. Singular solitons with single and multiple breather waves are also derived. Based on these findings, we can say that our implemented methods are more reliable and useful when retrieving optical soliton results for complicated nonlinear systems. Various potential features of the derived solutions are presented graphically.

13.
Vaccines (Basel) ; 11(9)2023 Aug 25.
Artículo en Inglés | MEDLINE | ID: mdl-37766098

RESUMEN

Explaining how individual choice and government policy can appear in the same context in real society is one of the most challenging scientific problems. Controlling infectious diseases requires effective prevention and control measures, including vaccination and self-defense measures. In this context, optimal control strategies incorporating vaccination and self-defense measures have been proposed using the framework of evolutionary game theory. This approach accounts for individuals' behavior and interactions in a population. It can provide insights into the effectiveness of different strategies for controlling the spread of infectious diseases. The optimal control strategy involves balancing the costs and benefits of vaccination, considering the dynamic interplay between the infected and susceptible populations. By combining evolutionary game theory with optimal control theory, we can identify the optimal allocation of resources for vaccination and self-defense measures, which can maximize the control of infectious diseases while minimizing costs. The model is utilized to analyze public health policies diseases, such as vaccination and self-defense strategies, to mitigate the spread of infectious in the context of delayed decision-making.

14.
Vaccines (Basel) ; 11(9)2023 Sep 11.
Artículo en Inglés | MEDLINE | ID: mdl-37766152

RESUMEN

Infectious diseases pose significant public health risks, necessitating effective control strategies. One such strategy is implementing a voluntary vaccination policy, which grants individuals the autonomy to make their own decisions regarding vaccination. However, exploring different approaches to optimize disease control outcomes is imperative, and involves assessing their associated costs and benefits. This study analyzes the advantages and disadvantages of employing a mixed-strategy approach under a voluntary vaccination policy in infectious disease control. We examine the potential benefits of such an approach by utilizing a vaccination game model that incorporates cost and benefit factors, where lower costs and higher benefits lead to reduced infection rates. Here, we introduce a mixed-strategy framework that combines individual-based risk assessment (IB-RA) and society-based risk assessment (SB-RA) strategies. A novel dynamical equation is proposed that captures the decision-making process of individuals as they choose their strategy based on personal or communal considerations. In addition, we explore the implications of the mixed-strategy approach within the context of social dilemmas. We examine deviations from expected behavior and the concept of social efficiency deficit (SED) by allowing for the evolution of vaccine strategy preferences alongside risk perception. By comprehensively evaluating the financial implications and societal advantages associated with the mixed-strategy approach, decision-makers can allocate resources and implement measures to combat infectious diseases within the framework of a voluntary vaccination policy.

15.
Cureus ; 15(7): e41262, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-37529825

RESUMEN

BACKGROUND: Consumption of savory crispy or fried snacks (SCFS), sugary snacks (SS), and sugar-sweetened beverages (SSB) is associated with an increased prevalence of obesity and noncommunicable diseases. We aimed to estimate the consumption of SCFS, SS, and SSB among adolescent males and females in Bangladesh and to report the factors associated with their consumption using data from a nationwide cross-sectional survey. METHODS: We interviewed 4,907 adolescent males and 4,865 females for the seven-day recall on intake of SCFS, SS, and SSB from 82 randomly selected clusters from rural, non-slum urban, and slum areas. Sociodemographic and anthropometry data were also collected. RESULTS: Consumption of SCFS, SS, and SSB for ≥7 times per week was reported by 11.6%, 28.9%, and 25.6% of the males and 4.9%, 24.8%, and 20.7% of the females, respectively. The weekly mean frequency of SCFS, SS, and SSB intake increased after adjustment for potential confounders among females with higher maternal education and for SCFS and SSB among males with the highest level of father's education. Increased intake of SS and SSB for both males and females was associated with dwelling in a female-headed household. SCFS intake was higher among both males and females from the richest households. Nutritional status, both overweight and obesity, and underweight, was not associated with a more frequent intake of SCFS and SS among males and females; however, a lower frequency of intake of SSB was observed among overweight and obese males. Screen time (television viewing: none, up to 1 hour, and more than 1 hour) was not associated with consumption of SCFS and SSB among both males and females. CONCLUSION: Consumption of unhealthy snacks and drinks is high among adolescents in Bangladesh and needs to be addressed through policy and program measures to abate the epidemic of obesity and associated NCD.

16.
PLoS One ; 18(7): e0283594, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37498833

RESUMEN

The Zoomeron equation is used in various categories of soliton with unique characteristics that arise in different physical phenomena, such as fluid dynamics, laser physics, and nonlinear optics. To achieve soliton solutions for the Zoomeron nonlinear structure, we apply the unified, the Kudryashov, and the improved Kudryashov techniques. We find periodic, breather, kink, anti-kink, and dark-bell soliton solutions from the derived optical soliton solutions. Bright, dark, and bright-dark breather waves are also established. Finally, some dynamic properties of the acquired findings are displayed in 3D, density, and 2D views.


Asunto(s)
Dinámicas no Lineales , Óptica y Fotónica , Fenómenos Físicos , Luz , Hidrodinámica
17.
Front Cell Dev Biol ; 11: 1164301, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37384249

RESUMEN

Cancer is a devastating disease and the primary cause of morbidity and mortality worldwide, with cancer metastasis responsible for 90% of cancer-related deaths. Cancer metastasis is a multistep process characterized by spreading of cancer cells from the primary tumor and acquiring molecular and phenotypic changes that enable them to expand and colonize in distant organs. Despite recent advancements, the underlying molecular mechanism(s) of cancer metastasis is limited and requires further exploration. In addition to genetic alterations, epigenetic changes have been demonstrated to play an important role in the development of cancer metastasis. Long non-coding RNAs (lncRNAs) are considered one of the most critical epigenetic regulators. By regulating signaling pathways and acting as decoys, guides, and scaffolds, they modulate key molecules in every step of cancer metastasis such as dissemination of carcinoma cells, intravascular transit, and metastatic colonization. Gaining a good knowledge of the detailed molecular basis underlying lncRNAs regulating cancer metastasis may provide previously unknown therapeutic and diagnostic lncRNAs for patients with metastatic disease. In this review, we concentrate on the molecular mechanisms underlying lncRNAs in the regulation of cancer metastasis, the cross-talk with metabolic reprogramming, modulating cancer cell anoikis resistance, influencing metastatic microenvironment, and the interaction with pre-metastatic niche formation. In addition, we also discuss the clinical utility and therapeutic potential of lncRNAs for cancer treatment. Finally, we also represent areas for future research in this rapidly developing field.

18.
Curr Issues Mol Biol ; 45(5): 3933-3952, 2023 May 02.
Artículo en Inglés | MEDLINE | ID: mdl-37232720

RESUMEN

The regulation of apoptosis (the programmed cell death) is dependent on the crucial involvement of BCL2 and BAX. The Bax-248G>A and Bcl-2-938 C>A polymorphic variations in the promoter sequences of the Bax and Bcl-2 gene have been recently associated with low Bax expression, progression to advanced stages, treatment resistance, and shortened overall survival rate in some hematological malignancies, including chronic myeloid leukemia (CML) and other myeloproliferative neoplasms. Chronic inflammation has been linked to various stages of carcinogenesis wherein pro-inflammatory cytokines play diverse roles in influencing cancer microenvironment leading to cell invasion and cancer progression. Cytokines such as TNF-α and IL-8 have been implicated in cancer growth in both solid and hematological malignancies with studies showing their elevated levels in patients. Genomic approaches have in recent years provided significant knowledge with the regard to the association of certain SNPs (single nucleotide polymerphisms) either in a gene or its promoter that can influence its expression, with the risk and susceptibility to human diseases including cancer. This study has investigated the consequences of promoter SNPs in apoptosis genes Bax-248G>A (rs4645878)/Bcl-2-938C>A (rs2279115) and pro-inflammatory cytokines TNF-α rs1800629 G>A/IL-8 rs4073 T>A on the risk and susceptibility towards hematological cancers. The study design has 235 individuals both male and female enrolled as subjects that had 113 cases of MPDs (myeloproliferative disorders) and 122 healthy individuals as controls. The genotyping studies were conducted through ARMS PCR (amplification-refractory mutation system PCR). The Bcl-2-938 C>A polymorphism showed up in 22% of patients in the study, while it was observed in only 10% of normal controls. This difference in genotype and allele frequency between the two groups was significant (p = 0.025). Similarly, the Bax-248G>A polymorphism was detected in 6.48% of the patients and 4.54% of the normal controls, with a significant difference in genotype and allele frequency between the groups (p = 0.048). The results suggest that the Bcl-2-938 C>A variant is linked to an elevated risk of MPDs in the codominant, dominant, and recessive inheritance models. Moreover, the study indicated allele A as risk allele which can significantly increase the risk of MPDs unlike the C allele. In case of Bax gene covariants, these were associated with an increased risk of MPDs in the codominant inheritance model and dominant inheritance model. It was found that the allele A significantly enhanced the risk of MPDs unlike the G allele. The frequencies of IL-8 rs4073 T>A in patients was found to be TT (16.39%), AT (36.88%) and AA (46.72%), compared to controls who were more likely to have frequencies of TT (39.34%), AT (37.70%) and AA (22.95%) as such, respectively. There was a notable overrepresentation of the AA genotype and GG homozygotes among patients compared to controls in TNF-α polymorphic variants, with 6.55% of patients having the AA genotype and 84% of patients being GG homozygotes, compared to 1.63% and 69%, respectively in controls. The data from the current study provide partial but important evidence that polymorphisms in apoptotic genes Bcl-2-938C>A and Bax-248G>A and pro-inflammatory cytokines IL-8 rs4073 T>A and TNF-α G>A may help predict the clinical outcomes of patients and determine the significance of such polymorphic variations in the risk of myeloproliferative diseases and their role as prognostic markers in disease management using a case-control study approach.

19.
Sci Rep ; 13(1): 8356, 2023 05 23.
Artículo en Inglés | MEDLINE | ID: mdl-37221186

RESUMEN

Evolutionary epidemiological models have played an active part in analyzing various contagious diseases and intervention policies in the biological sciences. The design in this effort is the addition of compartments for treatment and vaccination, so the system is designated as susceptible, vaccinated, infected, treated, and recovered (SVITR) epidemic dynamic. The contact of a susceptible individual with a vaccinated or an infected individual makes the individual either immunized or infected. Inventively, the assumption that infected individuals enter the treatment and recover state at different rates after a time interval is also deliberated through the presence of behavioral aspects. The rate of change from susceptible to vaccinated and infected to treatment is studied in a comprehensive evolutionary game theory with a cyclic epidemic model. We theoretically investigate the cyclic SVITR epidemic model framework for disease-free and endemic equilibrium to show stable conditions. Then, the embedded vaccination and treatment strategies are present using extensive evolutionary game theory aspects among the individuals in society through a ridiculous phase diagram. Extensive numerical simulation suggests that effective vaccination and treatment may implicitly reduce the community risk of infection when reliable and cheap. The results exhibited the dilemma and benefitted situation, in which the interplay between vaccination and treatment evolution and coexistence are investigated by the indicators of social efficiency deficit and socially benefited individuals.


Asunto(s)
Epidemias , Humanos , Simulación por Computador , Modelos Epidemiológicos , Teoría del Juego , Vacunación
20.
Insects ; 14(4)2023 Mar 31.
Artículo en Inglés | MEDLINE | ID: mdl-37103164

RESUMEN

Fall armyworm (FAW), Spodoptera frugiperda, is a major pest of maize that was first detected in Bangladesh in 2018 and rapidly spread throughout the maize-growing areas. The presence of FAW was monitored using sex pheromone traps. Farmers' pest management practices were assessed through a questionnaire. The damage is most apparent in the early and late whorl stages. As the crop is grown mostly from November to April, both vegetative and reproductive growth stages remain vulnerable to extensive damage. The survey results showed that 100% of the farmers used pesticides for FAW control, 40.4% handpicked and crushed egg masses, 75.8% handpicked and crushed caterpillars, and only 5.4% used other techniques like applying ash/sand in the funnel of maize. Commonly used pesticides included Spinosad, Emamectin benzoate, Imidacloprid, and others. Thirty-four percent of farmers applied pesticides twice in a season and 48% applied pesticides three times in a season and 54% and 39% of farmers sprayed chemicals at 7-day and 15-day intervals, respectively. FAW causes an average economic loss of 37.7% in maize production without pesticides. Increased use of pesticides to control FAW poses hazards to human health, wildlife, and the environment, and is expensive. Therefore, well-tested agroecological practices and bio-control agents are needed for sustainable FAW management.

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