Asunto(s)
Doxorrubicina/análogos & derivados , Erupciones por Medicamentos/etiología , Exantema/inducido químicamente , Polietilenglicoles/efectos adversos , Axila , Doxorrubicina/efectos adversos , Erupciones por Medicamentos/patología , Exantema/patología , Femenino , Ingle , Humanos , Persona de Mediana EdadAsunto(s)
Neoplasias de la Mama/diagnóstico , Carcinoma de Células de Merkel/diagnóstico , Errores Diagnósticos , Adenocarcinoma/diagnóstico , Anciano , Neoplasias de la Mama/patología , Carcinoma de Células de Merkel/patología , Diagnóstico Diferencial , Progresión de la Enfermedad , Femenino , Humanos , Tumores Neuroendocrinos/diagnósticoAsunto(s)
Neoplasias de la Boca , Papiloma , Femenino , Humanos , Neoplasias de la Boca/patología , Papiloma/patología , Adulto JovenRESUMEN
Metastatic cancer of unknown primary site appears in 5-10% of oncologic patients. The primary tumor is usually discovered at autopsy and only in 27% of patients alive. Metastases from cancer of unknown primary site may be located in the skin and subcutaneous tissue and it is the dermatologist the first in evaluating these patients. We present a case of cutanoeus metastases from moderately-differentiated adenocarcinoma of unknown primary site. The immunohistochemical study revealed positive staining for CEA and negative staining for PSA. The primary tumor could not be identified in spite of the imaging and endoscopic studies performed. Based on these studies we excluded a colorectal or prostatic origin and considered a pancreatic adencarcinoma as the possible primary tumor. Even though a minority of these patients will have a curable disease, the appropriate use of pathological diagnosis and selected imaging studies for an optimal management of patients with a tumor of unknown primary site should not be ignored.
Asunto(s)
Adenocarcinoma/secundario , Neoplasias Primarias Desconocidas , Neoplasias Cutáneas/secundario , Neoplasias Abdominales/sangre , Neoplasias Abdominales/diagnóstico , Neoplasias Abdominales/patología , Neoplasias Abdominales/secundario , Adenocarcinoma/sangre , Adenocarcinoma/diagnóstico , Adenocarcinoma/patología , Anciano , Progresión de la Enfermedad , Resultado Fatal , Humanos , Masculino , Neoplasias Cutáneas/sangre , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/patología , Neoplasias Torácicas/sangre , Neoplasias Torácicas/diagnóstico , Neoplasias Torácicas/patología , Neoplasias Torácicas/secundarioRESUMEN
A case of a lumbar aneurysmal bone cyst is presented in a 5 year-9 month old girl. The characteristics of this tumor are described, specifically in the spinal area, with particular reference to the diagnostic and therapeutic difficulties referred, taking into account the existing bibliography. The partial resection has been curative, as it has been frequently written about in publication worldwide and which suggest that surgery does not have to be aggressive in unapproachable cases and that radiotherapy is unnecessary.
Asunto(s)
Quistes Óseos/cirugía , Vértebras Lumbares , Adulto , Quistes Óseos/diagnóstico por imagen , Quistes Óseos/patología , Niño , Preescolar , Femenino , Humanos , Laminectomía , Vértebras Lumbares/patología , Vértebras Lumbares/cirugía , Mielografía , Enfermedades de la Columna Vertebral/diagnóstico por imagen , Enfermedades de la Columna Vertebral/patología , Enfermedades de la Columna Vertebral/cirugía , Tomografía Computarizada por Rayos XRESUMEN
We describe a female newborn infant who became severely hypoglycaemic (0.73 mg %), cyanosed and collapsed at five hours of age. After this episode she developed new hypoglycaemia and convulsions and did not tolerate short fasting periods. Physical examination revealed macrocephalia (PC 36 cm), prominent frontal bone and flat face. Hormonal tests showed normal insulines, a relative secondary hypothyroidism and GH, ACTH and cortisol deficiencies (GH, 0.15 and 11 ng/ml; cortisol, 3.5 and 2 mg %). The baby died at the age of 3 months after pulmonary aspiration. The findings at necropsy showed a normally developed brain and flat sella turcica with fragments of neurohypophysis without evidence of adenohypophysis and adrenals and thyroid markedly hypoplastic. Diagnosis of this entity as well as cases reported in pediatric literature are reviewed.