1.
J Org Chem
; 77(18): 8220-30, 2012 Sep 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22928642
RESUMEN
An efficient and inexpensive LiI-promoted O- to N-alkyl migration of 2-benzyloxy-, 2-allyloxy-, and 2-propargyloxypyridines and heterocycles is reported. The reaction produces the corresponding N-alkyl 2-pyridones and analogues under green, solvent-free conditions in good to excellent yields (30 examples, 20-97% yield). This method has been shown to be intermolecular and requires heat and lithium cation to occur.