RESUMEN
We describe a 39-year-old male patient who developed bleomycin-induced pneumonitis 2 years after completion of chemotherapy for nonseminomatous testicular cancer. Bleomycin sometimes causes fatal pulmonary toxicity, including bleomycin-induced pneumonitis. The central event in the development of pneumonitis is endothelial damage of the lung vasculature due to bleomycin-induced cytokines and free radicals. Pulmonary toxicity usually begins at bleomycin administration. The development of bleomycin-induced pneumonitis up to 6 months after bleomycin therapy has also been reported. We report a patient who developed bleomycin-induced pneumonitis 2 years after the initiation of bleomycin-containing chemotherapy regimens.
Asunto(s)
Antibióticos Antineoplásicos/efectos adversos , Bleomicina/efectos adversos , Neumonía/inducido químicamente , Adulto , Humanos , Masculino , Neoplasias Testiculares/tratamiento farmacológico , Factores de TiempoRESUMEN
Intrathecal application of chemotherapeutics has been the mainstay of central nervous system prophylaxis in acute lymphoblastic leukemia treatment. We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously. To our knowledge, this is the first case of methotrexate-related acute cerebellar syndrome.
Asunto(s)
Antimetabolitos Antineoplásicos/efectos adversos , Enfermedades Cerebelosas/inducido químicamente , Metotrexato/efectos adversos , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico , Enfermedad Aguda , Adulto , Antimetabolitos Antineoplásicos/administración & dosificación , Cuidados Críticos , Femenino , Humanos , Inyecciones Espinales , Metotrexato/administración & dosificación , Resultado del TratamientoRESUMEN
Carnitine palmitoyltransferase II (CPT-II) deficiency is the most common long-chain fatty acid oxidation defect, resulting in rhabdomyolysis and acute renal failure (ARF). There are three forms of CPT-II deficiency: the neonatal, infantile and adult form. We report an adult form of CPT-II deficiency in a patient who presented with attacks of exercise-induced rhabdomyolysis and ARF.