1.
Bioorg Med Chem Lett
; 20(4): 1436-9, 2010 Feb 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20097068
RESUMEN
Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.