RESUMEN
We analyzed the association of polymorphic variants of rs917997 (G/A) locus in IL18RAP gene and rs187238 (G/C) locus in IL18 gene with the risk of malignant non-Hodgkin's lymphomas in Novosibirsk population. Allele and genotype frequencies of the above loci were determined in patients (243 persons) and control group (371 persons) and compared using χ(2) test. None of the analyzed loci showed statistically significant association with the risk of malignant non-Hodgkin's lymphomas.
Asunto(s)
Alelos , Interleucina-18/genética , Linfoma no Hodgkin/genética , Polimorfismo de Nucleótido Simple , Receptores de Interleucina-18/genética , Adulto , Anciano , Estudios de Casos y Controles , Femenino , Frecuencia de los Genes , Sitios Genéticos , Genotipo , Humanos , Interleucina-18/inmunología , Linfoma no Hodgkin/inmunología , Linfoma no Hodgkin/patología , Masculino , Persona de Mediana Edad , Clasificación del Tumor , Receptores de Interleucina-18/inmunología , Riesgo , SiberiaRESUMEN
Multiple sclerosis is a classic multifactorial disease in which etiology interaction of external factors and structural features of a large number of genes plays an important role. Identifying risk factors for multiple sclerosis and creating an integrated model of pathogenesis are urgent tasks of neurology. Revealing true risk factors is possible only in studies with sufficient statistical power, so with a large amount of samples. We conducted the association study of CD40 gene's polymorphisms and multiple sclerosis among residents of the Russian Federation. The results demonstrated the need to combine data from different researchers in clinical studies to increase the power of the study.
Asunto(s)
Antígenos CD40/genética , ADN/genética , Predisposición Genética a la Enfermedad , Esclerosis Múltiple/genética , Polimorfismo Genético , Medición de Riesgo/métodos , Adulto , Alelos , Antígenos CD40/sangre , Femenino , Frecuencia de los Genes , Genotipo , Humanos , Incidencia , Masculino , Esclerosis Múltiple/sangre , Esclerosis Múltiple/epidemiología , Reacción en Cadena de la Polimerasa , Estudios Retrospectivos , Factores de Riesgo , Federación de Rusia/epidemiologíaRESUMEN
Breast cancer is the most incident cancer among women. We investigated the role of polymorphisms of folate metabolizing genes MTHFR (C677T and A1298C), SHMT1 (C1420T) and MTHFD (G1258A) in genetic susceptibility to this type of cancer. We determined allele and genotype frequencies in case (850 women with sporadic form of breast cancer) and control (810 women) groups. None of these polymorphisms was significantly associated with breast cancer risk. To increase statistical power of our study, we conducted a meta-analysis which included published genotype data and the results of our work. Meta-analysis also revealed no significant association of studied SNPs with breast cancer.