RESUMEN
INTRODUCTION: The coronavirus disease 2019 (COVID-19) pandemic has caused a high demand for health services, especially nursing. This workload can lead to emotional distress affecting their daily lives on a personal and professional basis. OBJECTIVE: To examine the prevalence of depression, anxiety, and stress in nurses and to analyze the factors associated with their presence during the COVID-19 pandemic. METHODS: An observational cross-sectional descriptive study was carried out in a second-level hospital in Mexico between September and October 2020. Within a population of 150 nurses invited to the study, 116 participated by answering a questionnaire regarding emotional aspects during their time caring for COVID-19 patients, as well as using the depression, anxiety, and stress scale (DASS-21). RESULTS: Among de 116 participants, 77.6% were females, and 22.4% were males. The 91.4% reported fear of spreading the disease to their families, and 59.5% reported that the death of their patients infected with COVID-19 affected them deeply. The factors associated with moderate to extremely severe levels of depression were the attitude of indifference from the community to their work during the pandemic (OR:2.66) and the increase consumption of addictive substances (OR:9.80). In the stress subscale, the variables that conferred a significant association was working inside the COVID-19 area (OR:17.05), being severely affected by the death of patients infected (OR:4.23), and fear of entering the red zone (OR:19.47). The need for psychological care was associated with moderate to severe depression and anxiety (OR:7.38, OR:9.50, respectively). For the anxiety subscale, no association with the studied variables was found. CONCLUSIONS: The study indicates a high prevalence of emotional distress among nurses, and that there were working, psychological and social factors associated with symptoms of depression and stress. Future research should focus on prevention measures and strategies to reduce psychological impact, as this could affect the quality of care provided to their patients.