1.
Bioorg Med Chem Lett
; 15(21): 4770-3, 2005 Nov 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16115768
RESUMEN
Cyclohexylglycine amides of various fluorinated pyrrolidines and azetidines were prepared and tested for activity against dipeptidyl peptidase IV and in vivo in the KK mouse model of type 2 diabetes. The tetrafluoropyrrolidide, cis-3,4-difluoropyrrolidide and the fluorinated azetidides displayed unexpectedly strong activity.