RESUMEN
A Zika virus (ZIKV) strain was isolated from an acute febrile patient during the Zika epidemics in Colombia. The strain was intraperitoneally inoculated into BALB/c mice, and 7 days postinoculation, neurological manifestations and ZIKV infection in the brain were demonstrated. The reported genome sequence is highly related to strains circulating in the Americas.
RESUMEN
Chagas disease is a complex zoonosis that affects around 8 million people worldwide. This pathology is caused by Trypanosoma cruzi, a kinetoplastid parasite that shows tremendous genetic diversity evinced in six distinct Discrete Typing Units (TcI-TcVI) including a recent genotype named as TcBat and associated with anthropogenic bats. TcI presents a broad geographical distribution and has been associated with chronic cardiomyopathy. Recent phylogenetic studies suggest the existence of two genotypes (Domestic (TcIDom) and sylvatic TcI) within TcI. The understanding of the course of the infection in different mouse models by these two genotypes is not yet known. Therefore, we infected 126 animals (ICR-CD1, National Institute of Health (NIH) and Balb/c) with two TcIDom strains and one sylvatic strain for a follow-up period of 60 days. We quantified the parasitaemia, immune response and histopathology observing that the maximum day of parasitaemia was achieved at day 21 post-infection. Domestic strains showed higher parasitaemia than the sylvatic strain in the three mouse models; however in the survival curves Balb/c mice were less susceptible to infection compared with NIH and ICR-CD1. Our results suggest that the genetic background plays a fundamental role in the natural history of the infection and the sympatric TcI genotypes have relevant implications in disease pathogenesis.
Asunto(s)
Enfermedad de Chagas/parasitología , Genotipo , Trypanosoma cruzi/genética , Animales , Susceptibilidad a Enfermedades , RatonesRESUMEN
Entre agosto de 1982 y octubre de 1984, diez y siete pacientes adultos con diagnóstico clínico, radiológico y artroscópico de artrosis patelofemoral de la rodilla, se les practicó patelectomia y cuadriceplastia de tipo dinámico. De los 18 casos, uno fue bilateral. Un seguimiento durante los siguientes 15 meses (promedio) demostró que el 89.9% de los resultados fueron satisfactorios, permitiendo a los pacientes retornar al trabajo y actividades normales a los cuatro meses (promedio). En ningún caso se dejó inmovilización post-operatoria, lo cual es ventajoso en los pacientes de edad avanzada puesto que permite iniciar los programas de rehabilitación muy precozmente
