A Semi-Blind Calibration and Compensation Method for Dynamic Range Recovery of Low-Power Pre-Amplifiers in MRI Receive Chains.

To enable wireless MRI receive arrays, per-channel power consumption must be reduced by a significant factor. To address this, a low-power SiGe alternative to industry standard MRI pre-amplifier blocks has been proposed and its impact on imaging performance evaluated in a benchtop environment. The SiGe amplifier reduces power consumption 28x, but exhibits increased non-linearity and reduced dynamic range relative to industry standard amplifiers. This distorts the images, causing reduced contrast and a blurring of fine features. In conjunction with the amplifier, a semi-blind calibration and compensation framework has been proposed to remove artifacts caused by this non-linearity. Requiring the knowledge of the calibration signal bandwidth, the associated peak transmit powers, and the distorted baseband signals, a second non-linearity is constructed that when cascaded with the receive chain produces a linear response. This method was evaluated for both knee and phantom image datasets of peak input power -20dBm with a -40dBm peak input power image as reference. In the benchtop environment, industry standard amplifiers produced input normalized RMSEs of 0.0199 and 0.0310 for phantom and knee datasets, respectively. The low-power SiGe amplifier resulted in RMSEs of 0.0869 and 0.1130 which were reduced to 0.0158 and 0.0168 following compensation, for phantom and knee images respectively. The ability to effectively compensate for this reduced dynamic range encourages further investigation of low-power SiGe amplifiers for power limited MRI receive arrays.

Biodegradable and flexible arterial-pulse sensor for the wireless monitoring of blood flow.

The ability to monitor blood flow is critical to patient recovery and patient outcomes after complex reconstructive surgeries. Clinically available wired implantable monitoring technology requires careful fixation for accurate detection and needs to be removed after use. Here, we report the design of a pressure sensor, made entirely of biodegradable materials and based on fringe-field capacitor technology, for measuring arterial blood flow in both contact and non-contact modes. The sensor is operated wirelessly through inductive coupling, has minimal hysteresis, fast response times, excellent cycling stability, is highly robust, allows for easy mounting and eliminates the need for removal, thus reducing the risk of vessel trauma. We demonstrate the operation of the sensor with a custom-made artificial artery model and in vivo in rats. This technology may be advantageous in real-time post-operative monitoring of blood flow after reconstructive surgery.

High-performance wireless powering for peripheral nerve neuromodulation systems.

Neuromodulation of peripheral nerves with bioelectronic devices is a promising approach for treating a wide range of disorders. Wireless powering could enable long-term operation of these devices, but achieving high performance for miniaturized and deeply placed devices remains a technological challenge. We report the miniaturized integration of a wireless powering system in soft neuromodulation device (15 mm length, 2.7 mm diameter) and demonstrate high performance (about 10%) during in vivo wireless stimulation of the vagus nerve in a porcine animal model. The increased performance is enabled by the generation of a focused and circularly polarized field that enhances efficiency and provides immunity to polarization misalignment. These performance characteristics establish the clinical potential of wireless powering for emerging therapies based on neuromodulation.