Vowel production: a potential speech biomarker for early detection of dysarthria in Parkinson's disease.

Objectives: Our aim is to detect early, subclinical speech biomarkers of dysarthria in Parkinson's disease (PD), i.e., systematic atypicalities in speech that remain subtle, are not easily detectible by the clinician, so that the patient is labeled "non-dysarthric." Based on promising exploratory work, we examine here whether vowel articulation, as assessed by three acoustic metrics, can be used as early indicator of speech difficulties associated with Parkinson's disease. Study design: This is a prospective case-control study. Methods: Sixty-three individuals with PD and 35 without PD (healthy controls-HC) participated in this study. Out of 63 PD patients, 43 had been diagnosed with dysarthria (DPD) and 20 had not (NDPD). Sustained vowels were recorded for each speaker and formant frequencies were measured. The analyses focus on three acoustic metrics: individual vowel triangle areas (tVSA), vowel articulation index (VAI) and the Phi index. Results: tVSA were found to be significantly smaller for DPD speakers than for HC. The VAI showed significant differences between these two groups, indicating greater centralization and lower vowel contrasts in the DPD speakers with dysarhtria. In addition, DPD and NDPD speakers had lower Phi values, indicating a lower organization of their vowel system compared to the HC. Results also showed that the VAI index was the most efficient to distinguish between DPD and NDPD whereas the Phi index was the best acoustic metric to discriminate NDPD and HC. Conclusion: This acoustic study identified potential subclinical vowel-related speech biomarkers of dysarthria in speakers with Parkinson's disease who have not been diagnosed with dysarthria.

Phonological and phonetic impairment in aphasic speech: an acoustic study of the voice onset time of six French-speaking aphasic patients.

The aim of the present study is to contribute to the description of the speech production deficits in French-speaking aphasic patients, so as to shed light on their potential phonetic and/or phonological disorders. Acoustic studies of aphasics' speech productions remain relatively infrequent, especially in French, and when entering into the specifics, often lead to inconsistent results. We conducted a multiple-case study on six aphasic patients, four with non-fluent aphasia and two with fluent aphasia. They were administered a variety of language and neuropsychological tasks, then they participated in a customized non-word repetition task. Acoustic analyses of their speech productions were performed, focussing on VOT as the main acoustic correlate of the voicing contrast for oral stops. Other atypicalities in their productions were also classified. Results showed variable and mainly "mixed" phonetic-phonological impairment profiles that differed from the traditional hypotheses made in the literature about the speech deficits to be expected as a function of type of aphasia. Our results support the use of acoustic analyses in order to complete language examination in aphasic patients but also suggest that the frontier between phonological and phonetic impairment is not clear-cut. These outcomes are better accounted for by theories and models postulating close relationships between the phonological and phonetic levels of processing.

The Effects of Aging on the Components of Auditory - Verbal Short-Term Memory.

This study aimed at exploring the effects of aging on the multiple components of the auditory-verbal short-term memory (STM). Participants of 45-54, 55-64, 65-74 and 75-84 years of age were presented STM tasks assessing short-term retention of order and item information, and of phonological and lexical-semantic information separately. Because older participants often present reduced hearing levels, we sought to control for an effect of hearing status on performance on STM tasks. Participants' hearing thresholds were measured with a pure-tone audiometer. The results showed age-related effects on all STM components. However, after hearing status was controlled for in analyses of covariance, the age-related differences became non-significant for all STM processes. The fact that age-related hearing loss may in large part explain decreases in performance on STM tasks with aging is discussed.

The impact of aging and hearing status on verbal short-term memory.

The aim of this study is to assess the impact of hearing status on age-related decrease in verbal short-term memory (STM) performance. This was done by administering a battery of verbal STM tasks to elderly and young adult participants matched for hearing thresholds, as well as to young normal-hearing control participants. The matching procedure allowed us to assess the importance of hearing loss as an explanatory factor of age-related STM decline. We observed that elderly participants and hearing-matched young participants showed equal levels of performance in all verbal STM tasks, and performed overall lower than the normal-hearing young control participants. This study provides evidence for recent theoretical accounts considering reduced hearing level as an important explanatory factor of poor auditory-verbal STM performance in older adults.

Changes in naming and semantic abilities with aging from 50 to 90 years.

The aim of this study was to determine whether naming difficulties arise in individuals as young as their 50s. Participants of 25-35, 50-59, 60-69, and above 70 years of age were given a picture naming task. To uncover subtle naming difficulties, latencies were analyzed in addition to accuracy. To control whether the expected slower naming latencies could be due to a general slowing affecting all cognitive tasks, participants were also given an odd/even judgment task to assess cognitive processing speed. The results confirmed that participants in their 50s presented decline in naming performance, reflected by an increase in naming latencies, whereas adults in their 60s and their 70s showed both a decrease in accuracy and an increase in latency. Moreover, the increase in naming latencies remained significant even after controlling for odd/even judgment latencies, suggesting a degradation specific to the picture naming task. We assumed that these slower latencies may result from a language-specific impairment. As a further test for language-specific degradation, participants' semantic capacities were also assessed with a synonym judgment task and the Pyramids and Palm Trees test. The above-70 group showed semantic degradation. The contributions of multiple factors to naming difficulties in aging are discussed.

Dissociable components of phonological and lexical-semantic short-term memory and their relation to impaired word production in aphasia.

This study assesses the dissociability of phonological and lexical-semantic short-term memory (STM) in two aphasic patients, B.N. and T.M., and explores the relationship between their STM deficits and their word production impairment. Picture naming performance suggests phonological language production impairment in B.N. and lexical-semantic language production impairment in T.M. On STM tasks, B.N. presented phonological STM impairment with preserved lexical-semantic STM, while T.M. presented the reverse profile. These results reveal a double dissociation between phonological and lexical-semantic STM capacities and suggest that our patients' STM impairment may be selectively related to their language production deficits.