[Prospective concepts of the military field therapy development].

The authors suggested the main problems solved by the military field therapy: development, scientific rationale, systematic improvement and practical application of the organizational form of first aid for the wounded in conditions of combat actions; research on the etiology, pathogenesis and clinical picture of states caused by effect of weapon of mass destruction (nuclear weapon, chemical weapon, etc); development of methods of diagnosis, prophylaxis and treatment of the abovementioned states; research of the pattern, clinical progression and treatment of somatization disorders in conditions of combat and casual activity of troops, analysis of morbidity among the troops and development of prophylaxis;formulation of military-medical questionnaire and development of the system of rehabilitation for the wounded. Searching for innovative methods for solving the problems of military field therapy is the current problem. Modern warfare changed the concept of delivery of health care, effectiveness of evacuative actions, training of medical personnel and medical maintaining. The authors came to conclusion that qualitative technology breakthrough in development of military medicine and military field therapy would not happen without strategic understanding and learning of prospect technologies.

[Effect of losartan on acute renal failure induced by severe ethylene glycol poisoning in rats].

The effect of an angiotensin receptor II antagonist (losartan) on the model acute renal failure (ARF) induced by severe ethylene glycol poisoning at 2/3 LD50 has been studied in rats. It is established that losartan administration (20 mg/kg for 72 h) produces a significant (4-fold) increase in the animal death rate, which is associated with ARF transition to a decompensation stage. Pronounced changes in the qualitative and quantitative composition of diurnal diuresis, more than 8-fold increase in the creatinine level, and 18-fold increase in the blood urea have been observed. Thus, the administration of losartan to ethylene glycol poisoned rats causes more pronounced degeneration of proximal tubule epithelium and destruction of glomeruli. It is concluded that the use of losartan for the treatment of ARF is inexpedient.