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Acta Otorhinolaryngol Ital ; 42(3): 243-249, 2022 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-35880365

RESUMEN

Objective: Patients with locally advanced laryngeal and hypopharyngeal cancer (LHC) are often treated with chemo-radiotherapy to avoid total laryngectomy, although voice problems may occur even if not markedly manifest. We sought to evaluate the impact of chemoradiation on voice and quality of life. Methods: We studied 21 patients with locally advanced LHC with tumour control at least two years after chemo-radiotherapy. None manifested clinical symptoms related to the treatment and maintained an activity considered as within normal limits. All patients had a voice handicap index (VHI) of less than 15. Voice function was evaluated by perceptual vocal analysis (CAPE-V) and aerodynamic and acoustic study. Quality of life was assessed with the EORTC-H&N35 (voice items 46, 53 and 54). Results: Voice changes were frequent, with alterations in all CAPE-V attributes, and predominantly type II and III spectrograms in acoustic analysis (78%). The EORTC-H&N35 scale showed a reduction in scores in 10-40% of items related to voice. Conclusions: Subclinical voice disorders are common after chemo-radiotherapy. Although patients consider vocal impairment to be very minor and to not interfere with their daily life, it may contribute to a reduced quality of life.


Asunto(s)
Neoplasias Hipofaríngeas , Neoplasias Laríngeas , Trastornos de la Voz , Quimioradioterapia/efectos adversos , Humanos , Neoplasias Hipofaríngeas/terapia , Neoplasias Laríngeas/tratamiento farmacológico , Neoplasias Laríngeas/terapia , Calidad de Vida , Trastornos de la Voz/diagnóstico , Trastornos de la Voz/etiología , Calidad de la Voz
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