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Lab Chip ; 14(19): 3695-9, 2014 Oct 07.
Artículo en Inglés | MEDLINE | ID: mdl-25102283

RESUMEN

We present a simple, rapid, benchtop, Foil Assisted Rapid Molding (FARM) method for the fabrication of microfluidic devices. This novel technique involves the use of aluminium foil, pen and an X-Y plotter to create semi-circular or plano-concave, shallow microchannels. It is an easy do-it-yourself (DIY) technique for creating a microfluidic device in three simple steps: (1) create a channel design using the CAD software, (2) plot the patterns on aluminium foil and (3) use the reverse of the engraved foil as a mold to create microfluidic devices. In this report, we present a detailed study of the proposed method by varying a range of parameters such as foil thickness, tip material, and tip sizes and by investigating their effect on the creation of channels with varying geometry. Furthermore, we demonstrated the cytocompatibility of these devices in vitro.


Asunto(s)
Aluminio , Diseño de Equipo/instrumentación , Diseño de Equipo/métodos , Técnicas Analíticas Microfluídicas/instrumentación , Línea Celular Tumoral , Separación Celular/instrumentación , Diseño de Equipo/economía , Humanos
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