Relationships between surface free energy, surface texture parameters and controlled drug release in hydrophilic matrices.

The study of controlled release and drug release devices has been dominated by considerations of the bulk or average properties of material or devices. Yet the outermost surface atoms play a central role in their performance. The objective of this article has been to characterize the surface of hydrophilic matrix tablets using the contact angle (CA) method to ascertain the surface free energy, and atomic force microscopy (AFM) and confocal microscopy (CM) for the physical characterization of the surface of the hydrophilic matrix. The surface free energy results obtained show that hydroxypropylmethylcellulose K15M hinders the spreading of water on the surface of the tablet, such that the concentration of HPMC K15M increases the reaction rate of the hydrophobic interactions between the chains of HPMC K15M which increases with respect to the rate of penetration of water into the tablet. In this study, we developed a new method to characterize the swelling of the tablets and established a relationship between the new method based on microswelling and the swelling ratio parameter. The surface texture parameters have been determined and the morphology of the tablets of the different formulations and the evolution of the surface morphology after interacting with the water, swelling and forming a gel layer were characterized. This work represents significant progress in the characterization of matrix tablets.

Estudio del caso del traslado del Hospital Esperi Sant de Santa Coloma de Gramenet / Case study of the transfer of Esperit Sant Hospital in Santa Coloma de Gramenet

Este trabajo trata de describir los principios fundamentales utilizados en la fase de planificción del trasado como guía metodología, en el caso del Hosital del Esperit Sant de Santa Coloma de Gramanet, que contribuyeron a cubrir las expectativas planteadas por el equipo de dirección (AU)

This paper seeks to describe the fundamental principles used in the planning phase of the transfer as a methodological guide in the cae o the Sant Esperit Hospital in Santa Coloma de Gramanet, which helped to cover the expectations held by the management team (AU)