Asunto(s)
Tumor del Seno Endodérmico , Neoplasias de Células Germinales y Embrionarias , Neoplasias Testiculares , Adulto , Tumor del Seno Endodérmico/diagnóstico por imagen , Fluorodesoxiglucosa F18 , Humanos , Masculino , Tomografía Computarizada por Tomografía de Emisión de Positrones , Radiofármacos , Neoplasias Testiculares/diagnóstico por imagenRESUMEN
BACKGROUND: Primary cilia (PC) are conserved structures in the adult thyroid gland of different mammals. It was recently described that in humans, PC are usually present as a single copy per follicular cell emerging from the follicular cell apex into the follicular lumen. METHODS: To understand the role developed by PC in thyroid hormonogenesis better, their changes in different human functional thyroid diseases (diffuse toxic hyperplasia/Graves' disease [GD] and nodular hyperplasia [NH]/nodular goiter), in comparison to normal thyroid tissue, were investigated using immunofluorescence, morphometry, and electron microscopy analyses. RESULTS: Significantly decreased ciliary frequencies were found in both NH (51.16 ± 11.69%) and GD (44.43 ± 23.70%) compared to normal thyroid tissue (76.09 ± 7.31%). Similarly, PC lengths were also significantly decreased in both NH (2.02 ± 0.35 µm) and GD (2.4 ± 0.48 µm) compared to normal glands (3.93 ± 0.90 µm). Moreover, in GD patients, hyperactive-follicle foci always showed diminished ciliary frequency and length compared to any other thyroid follicle pattern, independent of their thyroid status. Finally, in GD, the percentage of thyrocytes exhibiting PC in the "normal-appearance areas" was significantly lower in correspondence with the subsistence of signs of thyroid biosynthetic hyperactivity after long-term antithyroid drug treatment. CONCLUSIONS: The results suggest a direct relationship between ciliogenesis and both follicle activity and tissue heterogeneity in the functional pathology of the thyroid gland.
Asunto(s)
Cilios/patología , Bocio Nodular/patología , Enfermedad de Graves/patología , Células Epiteliales Tiroideas/patología , Glándula Tiroides/patología , Adulto , Anciano , Estudios de Casos y Controles , Cilios/ultraestructura , Femenino , Humanos , Masculino , Persona de Mediana Edad , Células Epiteliales Tiroideas/ultraestructura , Glándula Tiroides/ultraestructura , Adulto JovenRESUMEN
Lymphomas represent a wide group of heterogenic diseases with different biological and clinical behavior. The underlying microenvironment-specific composition seems to play an essential role in this scenario, harboring the ability to develop successful immune responses or, on the contrary, leading to immune evasion and even promotion of tumor growth. Depending on surrounding lymphoid infiltrates, lymphomas may have different prognosis. Moreover, recent evidences have emerged that confer a significant impact of main lymphoma's treatment over microenvironment, with clinical consequences. In this review, we summarize these concepts from a pathological and clinical perspective. Also, the state of the art of lymphoma's anti-idiotype vaccine development is revised, highlighting the situations where this strategy has proven to be successful and eventual clues to obtain better results in the future.
Asunto(s)
Antineoplásicos/farmacología , Trastornos Linfoproliferativos/tratamiento farmacológico , Trastornos Linfoproliferativos/patología , Microambiente Tumoral , Animales , Antineoplásicos/uso terapéutico , Humanos , Trastornos Linfoproliferativos/inmunologíaRESUMEN
El mioepitelioma de glándula salivar es una neoplasia benigna poco frecuente, que afecta principalmente a la parótida (40 %) y que muestra exclusivamente diferenciación mioepitelial. Histológicamente, exhibe variables patrones arquitecturales y diferentes tipos celulares, que pueden ser dominantes o entremezclarse en diferentes proporciones, lo que condiciona una marcada variabilidad morfológica en el material obtenido por PAAF y con frecuencia su incorrecta interpretación diagnóstica. Aportamos un caso de mioepitelioma parotídeo, diagnosticado inicialmente como maligno en la PAAF, con estudio histológico e inmunohistoquímico
Salivary gland myoepithelioma is a benign rare neoplasm whose main location is the parotid gland (40 %) and displays an exclusive myoepithelial differentation. Histologically it shows several and variable architectural patterns and cellular types that can be dominant or mixed in diverse proportions. This leads to a marked morphological variability in the material obtained by FNAB and not unfrequently to a wrong diagnostic interpretation. We report the case of a parotid lump, initially diagnosed as a malignant neoplasm by FNAB. Later, the tumor ,was correctly diagnosed as myoepithelioma after histological and inmunohistochemical examination
Asunto(s)
Masculino , Adulto , Humanos , Mioepitelioma/diagnóstico , Mioepitelioma/patología , Mioepitelioma/ultraestructura , Inmunohistoquímica/métodos , Citodiagnóstico/métodos , Neoplasias de la Parótida/diagnóstico , Neoplasias Basocelulares/complicaciones , Neoplasias Basocelulares/diagnóstico , Neoplasias Basocelulares/patología , Glándula Parótida/anatomía & histología , Glándula Parótida/citología , Glándula Parótida/patología , Saliva/citología , Microscopía/métodos , Diagnóstico DiferencialRESUMEN
El mioepitelioma de glándula salivar es una neoplasia benigna poco frecuente, que afectaprincipalmente a la parótida (40 %) y que muestra exclusivamente diferenciación mioepitelial.Histológicamente, exhibe variables patrones arquitecturales y diferentes tipos celulares, quepueden ser dominantes o entremezclarse en diferentes proporciones, lo que condiciona unamarcada variabilidad morfológica en el material obtenido por PAAF y con frecuencia su incorrectainterpretación diagnóstica. Aportamos un caso de mioepitelioma parotídeo, diagnosticadoinicialmente como maligno en la PAAF, con estudio histológico e inmunohistoquímico
Salivary gland myoepithelioma is a benign rare neoplasm whose main location is the parotidgland (40 %) and displays an exclusive myoepithelial differentation. Histologically it shows severaland variable architectural patterns and cellular types that can be dominant or mixed in diverseproportions. This leads to a marked morphological variability in the material obtained by FNABand not unfrequently to a wrong diagnostic interpretation.We report the case of a parotid lump, initially diagnosed as a malignant neoplasm by FNAB.Later, the tumor ,was correctly diagnosed as myoepithelioma after histological and inmunohistochemicalexamination
Asunto(s)
Masculino , Adulto , Humanos , Mioepitelioma/patología , Neoplasias de la Parótida/patología , Glándulas Salivales/patología , Diagnóstico DiferencialAsunto(s)
Antifúngicos/efectos adversos , Enfermedad Hepática Inducida por Sustancias y Drogas/etiología , Itraconazol/efectos adversos , Enfermedad Aguda , Adulto , Agricultura , Antifúngicos/uso terapéutico , Candidiasis/tratamiento farmacológico , Susceptibilidad a Enfermedades , Interacciones Farmacológicas , Herbicidas/envenenamiento , Humanos , Itraconazol/uso terapéutico , Masculino , Exposición Profesional/efectos adversosRESUMEN
Eosinophilic gastroenteritis (EGE) is a rare inflammatory disease characterized by diffuse or scattered eosinophilic infiltration of the digestive tract and usually by peripheral blood eosinophilia. The most common presenting symptoms of EGE are abdominal pain, vomiting and diarrhea, but clinical features depend on which layers or location of gastrointestinal tract are involved. Treatment with corticosteroids results in clinical and histological remission in most patients and surgery can be avoided if a correct diagnosis is made. Previous history of allergy is a key to diagnosing EGE, but peripheral eosinophilia may be absent in some patients under concomitant treatment with corticosteroids. Radiological and endoscopic findings are also nonspecific and diagnosis must always be histologically confirmed. The gastrointestinal involvement is patchy in distribution, so more than one panendoscopic examination is often necessary to establish the diagnosis, and surgical or CT-guided full-thickness biopsy is needed in patients with muscular or serosal involvement. It emphasises the importance of a high index of clinical suspicion, which mainly depends on knowledge of natural history of the disease. We report here a case of EGE associated with transmural eosinophilic cholecystocholangitis, in a patient who presented with dyspeptic symptoms and recurrent cholestasis responsive to corticoesteroids. To our knowledge, this patient represents the second case, in the English literature, in which corticoid-responsive cholangitis was associated to histologically proven eosinophilic cholecystitis and gastrointestinal involvement, suggesting that EGE must always be considered in the differential diagnosis of biliary tract disease in patients with eosinophilia and/or atopic diseases.