Cannabidiol as an Alternative Analgesic for Acute Dental Pain.

Odontogenic pain can be debilitating, and nonopioid analgesic options are limited. This randomized placebo-controlled clinical trial aimed to assess the effectiveness and safety of cannabidiol (CBD) as an analgesic for patients with emergency acute dental pain. Sixty-one patients with moderate to severe toothache were randomized into 3 groups: CBD10 (CBD 10 mg/kg), CBD20 (CBD 20 mg/kg), and placebo. We administered a single dose of respective oral solution and monitored the subjects for 3 h. The primary outcome measure was the numerical pain differences using a visual analog scale (VAS) from baseline within and among the groups. Secondary outcome measures included ordinal pain intensity differences, the onset of significant pain relief, maximum pain relief, changes in bite force within and among the groups, psychoactive effects, mood changes, and other adverse events. Both CBD groups resulted in significant VAS pain reduction compared to their baseline and the placebo group, with a maximum median VAS pain reduction of 73% from baseline pain at the 180-min time point (P < 0.05). CBD20 experienced a faster onset of significant pain relief than CBD10 (15 versus 30 min after drug administration), and both groups reached maximum pain relief at 180-min. Number needed to treat was 3.1 for CBD10 and 2.4 for CBD20. Intragroup comparisons showed a significant increase in bite forces in both CBD groups (P < 0.05) but not in the placebo group (P > 0.05). CBD20 resulted in a significant difference in mean percent bite force change in the 90- and 180-min time points compared to the placebo group (P < 0.05). Compared to placebo, sedation, diarrhea, and abdominal pain were significantly associated with the CBD groups (P < 0.05). There were no other significant psychoactive or mood change effects. This randomized trial provides the first clinical evidence that oral CBD can be an effective and safe analgesic for dental pain.

[Functional assessment in total knee arthroplasty comparing the posterior cruciate ligament preservation versus postero-stabilization]. / Valoración funcional en artroplastía total de rodilla comparando la preservación del ligamento cruzado posterior versus posteroestabilización.

INTRODUCTION: The two most commonly used types of prostheses are the total knee prosthesis with posterior cruciate ligament preservation and posterior cruciate ligament replacement. OBJECTIVE: To assess whether there is a difference in functionality between the two procedures. MATERIAL AND METHODS: Observational, retrospective and cross-sectional study with 134 patients divided into group A (N = 67) with ligament preservation and group B (N = 67) with posterior substituting. Using the American Association Scale for Knee Prosthetics with Insall modification to assess functionality. Statistical analysis: use of 2 with Yates correction. RESULTS: In group A the results: excellent (31%); good (24%); regular (22%) bad (22%). In group B the results: excellent (34%); good (31%); regular (16%) and bad (19%); without statistical difference between the two groups. CONCLUSIONS: No statistically significant difference was observed between age, gender, laterality of injury, or between number of patients with excellent results, good regular and bad according to the scale used. The high percentage of poor results in both groups of this series for the knee prosthesis is striking.

INTRODUCCIÓN: Los dos tipos de prótesis que más se utilizan en la actualidad son la prótesis total de rodilla con preservación del ligamento cruzado posterior y con sustitución del ligamento cruzado posterior. OBJETIVO: Valorar si existe diferencia en la funcionalidad entre ambos procedimientos. MATERIAL Y MÉTODOS: Estudio observacional, retrospectivo y transversal con 134 pacientes divididos en grupo A (N = 67) con preservación del ligamento y grupo B (N = 67) con posteroestabilización. Uso de la Escala de la Asociación Americana para Prótesis de Rodilla con la modificación de Insall para valorar funcionalidad. Análisis estadístico: Uso de 2 con corrección de Yates. RESULTADOS: En el grupo A los resultados: excelentes (31%); buenos (24%); regulares (22%) y malos (22%). En el grupo B los resultados: excelentes (34%); buenos (31%); regulares (16%) y malos (19%); sin diferencia estadísticamente entre ambos grupos. CONCLUSIONES: No se observó diferencia estadísticamente significativa entre edad, género, lateralidad de la lesión ni entre número de pacientes, con resultados excelentes, buenos regulares y malos de acuerdo con la escala utilizada. Llama la atención el elevado porcentaje de malos resultados en ambos grupos de esta serie en la prótesis de rodilla.

[Risk factors associated to musculoskeletal pathologies in athletes with cavus foot through baropodometric studies]. / Factores de riesgo asociados a patologías musculoesqueléticas en deportistas con pie cavo anterior a través de estudios de baropodometría.

INTRODUCTION: The cavus foot is a musculoskeletal pathology with an increase of the medial arch of the concavity of the foot. The etiology of the cavus foot is still enigmatic, it is related with neurologic conditions, Charcot-Marie-Tooth disease, Friedreich's ataxia, and cerebral palsy. The aim of this research was to analyze the plantar pressure distribution of the feet on young athletes with cavus foot. MATERIAL AND METHODS: Eighty-three young athletes between nine and 20 years old, that presented cavus feet pathology were recruited. The mass and height average were 56.9 ± 12.36 kg and 1.61 ± 0.10 m respectively. Plantar pressure distribution of the feet was recorded during static conditions. The hindfoot and forefoot pressure were compared in each foot. RESULTS: The plantar pressure distribution were categorized in three groups. In the first group the participants presented higher pressure in the hindfoot than forefoot, in the second group, the athletes showed similar pressure in the posterior and anterior region of the feet and in the last one, the subjects revealed higher pressure in the forefoot. To be considered in one of the three groups, the difference of pressure between the posterior and anterior part of the foot was established at 16%. CONCLUSION: Many musculoskeletal disorders in the human body are biomechanical in origin and related with foot anatomy. The cavus foot is a pathology with high prevalence in athletes and it is related with the mechanical forces over the feet during dynamic conditions.

INTRODUCCIÓN: El pie cavo es una patología musculoesquelética con un aumento del arco medial del pie. La etiología del pie cavo aún es incomprensible, está relacionada con afecciones neurológicas, enfermedad de Charcot-Marie-Tooth, ataxia de Friedreich y parálisis cerebral. El objetivo de esta investigación fue analizar la distribución de la presión plantar en atletas jóvenes con pie cavo. MATERIAL Y MÉTODOS: Se reclutaron 83 atletas jóvenes de entre nueve y 20 años de edad, que presentaban patología de pie cavo. La masa y el promedio de altura fueron 56.9 ± 12.36 kg y 1.61 ± 0.10 m, respectivamente. La distribución de la presión plantar de los pies se registró durante condiciones estáticas. Se compararon las presiones del antepié y el retropié. RESULTADOS: La distribución de la presión plantar se categorizó en tres grupos. En el primer grupo los participantes presentaron mayor presión en la parte anterior del pie; en el segundo grupo los atletas mostraron una presión similar en la región posterior y anterior de los pies y en el último los sujetos revelaron una mayor presión en el retropié. Para ser considerado en uno de los tres grupos, la diferencia de presión entre la parte posterior y anterior del pie se estableció en 16%. CONCLUSIÓN: Muchos trastornos musculoesqueléticos en el cuerpo humano son de origen biomecánico y están relacionados con la anatomía del pie. El pie cavo es una patología con alta prevalencia en atletas y está relacionada con las fuerzas mecánicas sobre los pies en condiciones dinámicas.

[Exposed dislocation of the first and second cuneiform bones and fracture in situ of the third cuneiform bone of the foot: Clinical case and literature review]. / Luxación expuesta de la primera y segunda cuña y fractura in situ de la tercera cuña del pie: Caso clínico y revisión de la literatura.

BACKGROUNDS: The isolated fracture/dislocation of the cuneiform bones is a not very frequent event and only a few cases have been reported in the literature. This type of event is presented as a variation of the Lisfranc injuries. The present report shows a rare clinical case of a patient with dislocation of the first and second cuneiform bones and fracture in situ of the third cuneiform bone of the left foot. CASE REPORT: A 49-year-old female patient presented severe traumatism of the dorsum of the foot with bony and soft tissue exposure as a result of a car accident. The patient underwent surgery in the emergency department consisting of surgical cleaning, debridement, reduction of dislocation of the first and second cuneiform bones and percutaneous fixation with 2.0 mm Kirschner wires. RESULTS: After the surgery, the patient was found to be in good general condition, oriented without pain, stable, conscious, without traces of active bleeding from the wound and with the presence of Kirschner wires in an appropriate position. DISCUSSION: An exhaustive inspection of the injury is recommended through the analysis of X-ray images, CT scans or magnetic resonance imaging, especially in unexposed lesions in order to apply the appropriate treatment and be able to achieve a prompt recovery of the patient.

ANTECEDENTES: La fractura y la luxación aislada de los huesos cuneiformes son un evento no muy frecuente y sólo pocos casos han sido reportados en la literatura. Este tipo de eventos se presenta como una variación de las lesiones de Lisfranc. El presente reporte muestra un caso clínico poco frecuente de un paciente con luxación de la primera y segunda cuña y fractura in situ de la tercera cuña del pie izquierdo. CASO CLÍNICO: Mujer de 49 años de edad, que presentó traumatismo severo del dorso del pie con exposición de tejido óseo y blando como consecuencia de atropellamiento. La paciente fue sometida a cirugía en el Servicio de Urgencias, donde se realizó aseo quirúrgico, desbridamiento, reducción de la luxación de la primera y segunda cuña y fijación percutánea con clavillos Kirschner de 2.0 mm. RESULTADOS: Posterior a la cirugía, la paciente se reportó con buen estado en general, orientada, sin facie de dolor, estable, consciente, sin huellas de sangrado activo por la herida y con presencia de clavillos Kirschner en adecuada posición. DISCUSIÓN: Se recomienda una inspección exhaustiva de la lesión a través del análisis de las imágenes de rayos X, tomografía computarizada o imágenes de resonancia magnética, especialmente en lesiones no expuestas, pues con ello se puede aplicar el tratamiento adecuado y lograr una pronta recuperación del paciente.

[Biomechanical analysis through numerical simulation of rupture of the tibial posterior tendon in valgus flat foot: a cadeveric study]. / Análisis biomecánico a través de simulación numérica de la ruptura del tendón del tibial posterior en el pie plano valgo: estudio en cadáver.

The insufficiency of the posterior tibial tendon is the most common acquired cause of pain related to valgus flatfoot deformity in adults. The acquired flatfoot adult is a very painful symptomatic deformity resulting from a gradual stretching (attenuation) of the posterior tibial tendon and ligaments that support the arch of the foot. The progressive pain acquired flatfoot adult affects four times more women than men. Some factors that contribute to increased risk of acquired flatfoot in adults, are diabetes, hypertension and obesity. It is thought that the combination of the following events is the cause of acquired flatfoot adult. Johnson Strom classification modified by Mayerson evaluates in 4 stages. This study was divided into 3 stages: Stage 1: Dissection and three-dimensional analysis of the tendon, Step 2: Application of tools bioengineering to determine the causes of rupture of the tibial tendon: Stage 3: Evaluation of 24 patients with flatfoot disease valgus for describe the deformity.

La insuficiencia del tendón del tibial posterior es la causa adquirida de dolor más común relacionada con la deformidad de pie plano valgo en adultos. El pie plano adquirido por el adulto es una deformidad sintomática muy dolorosa que resulta de un estiramiento gradual (atenuación) del tendón del tibial posterior, así como de los ligamentos que sostienen el arco de la planta del pie. El dolor progresivo en el pie plano adquirido por el adulto afecta cuatro veces más a las mujeres que a los hombres. Algunos factores que contribuyen a incrementar el riesgo del pie plano adquirido en el adulto son la diabetes, la hipertensión y la obesidad. Se piensa que la combinación de los eventos siguientes es la causa del pie plano adquirido por el adulto. La clasificación de Johnson Strom modificada por Mayerson lo evalúa en cuatro estadios. Este estudio se dividió en tres etapas: etapa 1: disección y análisis tridimensional del tendón, etapa 2: aplicación de herramientas de bioingeniería para determinar las causas de ruptura del tendón del tibial posterior y etapa 3: evaluación de 24 pacientes con enfermedad de pie plano valgo para describir la deformidad.

[A cadaveric study of a new capsulorrhaphy for the surgical treatment of hallux valgus]. / Propuesta de una capsulorrafia como parte del tratamiento quirúrgico del hallux valgus: estudio en cadáver.

BACKGROUND: There are many surgical options for the treatment of hallux valgus in combination with capsular repairs for the correction of hallux valgus. MATERIAL AND METHODS: This report corresponds to a descriptive study where a new capsulorrhaphy technique in hallux valgus is proposed. Six dissections were performed on cadavers with hallux valgus deformity using the following surgical technique: medial approach on the first toe longitudinally, dissecting by planes and locating the metatarsophalangeal joint capsule; it was incised longitudinally. The capsule was separated and an exostectomy of the first metatarsal head was done, the edges were regularized and a release of the abductor hallucis was performed. Later, the capsular remnant was resected and repaired. RESULTS: Six cadaveric feet with hallux valgus were studied, five with mild deformity, one with moderate deformity, one foot with the 2nd finger on supraductus. DISCUSSION: Many capsular repairs have been reported in the literature, including «L¼, triangular, «V-Y¼, rectangular, with satisfactory results, along with osteotomy of the first metatarsal. In this report, a new capsular repair was described. CONCLUSION: Applying this new capsular repair, we reduced the metatarsophalangeal and intermetatarsal angles and achieved a capsular closure with suitable tension; the metatarsophalangeal joint mobility was preserved.

ANTECEDENTES: Existen numerosas técnicas quirúrgicas para el tratamiento del hallux valgus en combinación con diversas capsulorrafias para su corrección. MATERIAL Y MÉTODOS: El trabajo presentado corresponde a un estudio descriptivo donde se propone una capsulorrafia no desarrollada con anterioridad del hallux valgus. Se realizaron seis disecciones en cadáver con la deformidad de hallux valgus a través de la siguiente técnica quirúrgica: abordaje medial sobre el primer dedo del pie de manera longitudinal, disecando por planos y localizando la cápsula articular metatarsofalángica; se incidió longitudinalmente. Se separó la cápsula y se llevó a cabo la exostectomía de la cabeza del primer metatarsiano; se regularizaron los bordes y se realizó la liberación del abductor del primer dedo. Posteriormente, se resecó el remanente capsular y se reparó. RESULTADOS: Seis pies de cadáver portadores de hallux valgus; cinco con deformidad leve, uno pie moderado, un pie con segundo dedo en supraducto. DISCUSIÓN: Muchas capsulorrafias han sido reportadas en la literatura, incluyendo en «L¼, triangular, «V-Y¼, rectangular, con resultados satisfactorios, junto con las osteotomías del primer metatarsiano. Aquí se describe una propuesta de capsulorrafia. CONCLUSIÓN: La corrección de la deformidad del hallux valgus en pies de cadáver aplicando esta propuesta de reparación capsular fue satisfactoria, con adecuada tensión y una movilidad conservada de la articulación metatarsofalángica.

Síndrome del túnel del tarso: secundario a insuficiencia venosa. Reporte de un caso / Tarsal tunnel syndrome secondary to venous insufficiency: Case report

El síndrome del túnel del tarso se define como una neuropatía compresiva extrínseca y/o intrínseca del nervio tibial posterior o de una de sus ramas siendo una de sus causas la insuficiencia vascular. Caso clínico: femenina de 51 años, originaria de León, Guanajuato. Hipertensa, síndrome de Guillain-Barré hace ocho años, insuficiencia vascular y obesidad. Inicia con dolor en tobillo y talón izquierdo, manejada con AINES y rehabilitación con mejoría parcial, se realizan radiografías y resonancia magnética nuclear del tobillo izquierdo con datos de pinzamiento posterior, se realiza artroscopía y mejora un mes presentándose dolor intenso en el tobillo y la planta del pie y disestesias, se hace electromiografía con datos de lesión del tibial posterior. Cuenta con historia clínica, perfil prequirúrgico, dorsoplantar y lateral, se realiza una artroscopía encontrándose una tendinitis del Flexor Hallucis Longus (FHL), sinovitis y un pinzamiento posterior del tobillo, se hace sinovectomía, descompresión y un peinado del FHL. Mala evolución, se realiza electromiografía con axonotmesis de la rama plantar medial. Se realiza la liberación del nervio encontrándose el plexo venoso de Lazhortes tortuoso comprimiendo en todo su trayecto. Una de las causas es por la compresión intrínseca secundaria a tumores, modificaciones de la anatomía del túnel del tarso; sin embargo, menos frecuente, las várices pueden confundir el diagnóstico y llegar a producir un daño irreparable para el paciente si no se trata a tiempo. La paciente se encuentra actualmente sin dolor que le posibilita la marcha, con disestesias leves del primer dedo y movilidad limitada para su flexión.

Tarsal tunnel syndrome is defined as an extrinsic and/or intrinsic compressive neuropathy of the posterior tibial nerve or one of its branches. Its causes include venous insufficiency. Clinical case: 51 year-old female patient from León, Guanajuato. Hypertensive, with Guillain-Barré syndrome for eight years, vascular insufficiency and obesity. Her condition started with left ankle and heel pain; she was treated with NSAIDs and rehabilitation and achieved partial improvement. X-rays and MRI of the left ankle showed posterior impingement. She underwent arthroscopy and improved but one month later she presented with severe pain in the left ankle and sole and dysesthesias. Electromyography showed a lesion of the posterior tibial nerve. We had the patient's case history, preoperative tests, and dorsoplantar and lateral X-ray views. The arthroscopic diagnosis was flexor hallucis longus (FHL) tendinitis, synovitis and posterior ankle impingement. Synovectomy, decompression and smoothening of the FHL tendon were performed. The patient did poorly and underwent electromyography with axonotmesis of the medial plantar branch. After the nerve was released, Lazorthes venous plexus was found to be tortuous and compressing the entire nerve tract. The possible causes for this include intrinsic compression secondary to tumors, and anatomical changes of the tarsal tunnel. However, less often varices may confound the diagnosis and cause irreversible damage if not treated timely. The patient is currently pain free and can walk, has mild dysesthesias of the first toe and limited flexion.

[Tarsal tunnel syndrome secondary to venous insufficiency. Case report]. / Síndrome del túnel del tarso: secundario a insuficiencia venosa. Reporte de un caso.

Tarsal tunnel syndrome is defined as an extrinsic and/or intrinsic compressive neuropathy of the posterior tibial nerve or one of its branches. Its causes include venous insufficiency. Clinical case: 51 year-old female patient from León, Guanajuato. Hypertensive, with Guillain-Barré syndrome for eight years, vascular insufficiency and obesity. Her condition started with left ankle and heel pain; she was treated with NSAIDs and rehabilitation and achieved partial improvement. X-rays and MRI of the left ankle showed posterior impingement. She underwent arthroscopy and improved but one month later she presented with severe pain in the left ankle and sole and dysesthesias. Electromyography showed a lesion of the posterior tibial nerve. We had the patient's case history, preoperative tests, and dorsoplantar and lateral X-ray views. The arthroscopic diagnosis was Flexor Hallucis Longus (FHL) tendinitis, synovitis and posterior ankle impingement. Synovectomy, decompression and smoothening of the FHL tendon were performed. The patient did poorly and underwent electromyography with axonotmesis of the medial plantar branch. After the nerve was released, Lazorthes venous plexus was found to be tortuous and compressing the entire nerve tract. The possible causes for this include intrinsic compression secondary to tumors, and anatomical changes of the tarsal tunnel. However, less often varices may confound the diagnosis and cause irreversible damage if not treated timely. The patient is currently pain free and can walk, has mild dysesthesias of the first toe and limited flexion.

[Anatomical variants of the medial calcaneal nerve and the Baxter nerve in the tarsal tunnel]. / Variantes anatómicas del nervio calcáneo medial y nervio de Baxter en el túnel del tarso.

The tarsal tunnel is composed of the posterior border of the medial malleoulus, the posterior aspect of the talus and the medial aspect of the calcaneus. The medial calcaneal nerve emerges from the posterior aspect of the posterior tibial nerve in 75% of cases and from the lateral plantar nerve in the remaining 25%. Finally, the medial calcaneal nerve ends as a single terminal branch in 79% of cases and in numerous terminal branches in the remaining 21%. To describe the anatomical variants of the posterior tibial nerve and its terminal branches. To describe the steps for tarsal tunnel release. To describe Baxter nerve release. The anatomical variants of the posterior tibial nerve and its terminal branches within the tarsal tunnel were studied. Then the Lam technique was performed; it consists of: 1) opening of the laciniate ligament, 2) opening of the fascia over the abductor hallucis muscle, 3) exoneurolysis of the posterior tibial nerve and its terminal branches, identifying the emergence and pathway of the medial calcaneal branch, the lateral plantar nerve and its Baxter nerve branch and the medial plantar nerve. Baxter nerve was found in 100% of cases. In 100% of cases in our series the nerve going to the abductor digiti minimi muscle of the foot was found; 87.5% of cases had two terminal branches. The dissections proved that a crucial step was the release of the distal tarsal tunnel.

Type-specific opsonophagocytosis of group A Streptococcus by use of a rapid chemiluminescence assay.

A whole-blood chemiluminescence (CL) assay was developed to determine the presence of type-specific opsonic antibodies against group A streptococcus (GAS). Convalescent sera with high bactericidal activities against an M-1 serotype were used to opsonize different M-types of GAS. CL responses were monitored for 20 min, and results were expressed as integral counts/minute per phagocyte. CL responses of phagocytes incubated with M-1 GAS opsonized with homologous (M-1) serum were significantly higher than responses of phagocytes incubated with heterologous (M-3) GAS. Adsorption of convalescent serum against the homologous, but not the heterologous, strain markedly reduced the CL response, demonstrating type specificity. The CL assay showed a high correlation with the indirect bactericidal test (r=0.90). In conclusion, this CL assay is a rapid, highly sensitive, specific, and reproducible method for quantifying type-specific opsonic antibodies against GAS and will be a useful tool for future clinical, basic science, and epidemiological studies.