RESUMEN
An anomalous high frequency of ATL was observed in a remote 'noir maroons' village of French Guiana. Since it is not clear if HTLV-I is responsible for different frequencies of disease in different geographical areas, we undertook a comparison of the population with a similar one located in Gabon. We found a much higher degree of gp46 surface envelope glycoprotein sequence conservation in the Guianese village than in the Gabonese one.
Asunto(s)
Variación Genética , Virus Linfotrópico T Tipo 1 Humano/genética , Leucemia-Linfoma de Células T del Adulto/virología , Secuencia de Bases , Secuencia Conservada , ADN Viral , Femenino , Guyana Francesa/epidemiología , Gabón/epidemiología , Productos del Gen env/genética , Humanos , Leucemia-Linfoma de Células T del Adulto/epidemiología , Masculino , Datos de Secuencia Molecular , Filogenia , Proteínas Oncogénicas de Retroviridae/genética , Alineación de SecuenciaRESUMEN
Clinical studies by Dr R. Pradinaud (Cayenne) has given prominence to the symptoms of "papillonite": its primary and secondary cutaneous lesions, their localisation and evolution as well as its accompanying symptoms such as respiratory pathology. Epidemiologic survey shows a parallelism between the occurrence of papillonite and the presence of the moth Hylesia urticans. The urticant apparatus of this moth was studied with the scanning electron microscope. "Arrow" (fléchettes) were found and they more or less resemble the urticant apparatus of Thaumetopoea pityocampa Schiff caterpillar. The mechanism of action has been studied in the animal and in humans. Extracts prepared from the "arrows" have been rested in vivo guinea-pigs (bleu Evans, Liacopoulos et al.). The findings seem to incriminate an histamino-liberation.