[A preliminary study on the tolerability and efficacy of nabumetone in the treatment of acute or chronic and very painful rheumatic diseases]. / Studio preliminare di tollerabilità ed efficacia nel trattamento di patologie acute o croniche di pertinenza reumatologica con alta risposta algica con nabumetone.

Twenty patients (2 males, 18 females, age range 33-69, average 55.85 years) with diagnoses of variously localized osteoarthritis (18 cases) or acute joint pain (2 cases) were studied. All patients were given one 1-g tablet of nabumetone every evening before going to bed, for 8 days. In three cases treatment was withdrawn immediately after the first dose due to the onset of allergic (2 cases) or dyspeptic (1 case) symptoms. Initially, all patients complained of considerable pain, both at rest and during active and passive movements with correlated functional limitation of the joints involved. Treatment resulted in considerable subsidence of symptoms from the very first days of therapy. Statistical calculation of the score showed significant improvement. Parameters of tolerability did not show significant changes from baseline. Local tolerability was generally good. The fact of the single daily dose has certainly contributed to the patients' good compliance.