1.
Bioorg Med Chem
; 7(6): 1131-9, 1999 Jun.
Artículo
en Inglés
| MEDLINE
| ID: mdl-10428384
RESUMEN
Replacement of the 3,4-dialkoxyphenyl substructure common to a number of PDE4 inhibitors with a 2-alkyl-7-methoxybenzofuran unit is described. This substitution can result in either enhancement or substantial reductions in PDE4 inhibitory activity depending on the system to which it is applied. An in vitro SAR study of a potent series of 4-(2-heteroaryl-ethyl)-benzoiurans 26 is also presented.