RESUMEN
BACKGROUND: We reviewed our surgical treatment of chronic axial cervical pain over a 4-year period to determine whether surgery in selected cases was associated with favorable outcomes. METHODS: We retrospectively studied 27 consecutive cases (20 patients with follow-up) of longstanding axial cervical spine pain treated surgically by a single surgeon from June 1994 through August 1998. Diagnostic workup included the following when appropriate: Minnesota Multiphasic Personality Inventory (MMPI) with interview, provocative diskography (with a nonpainful control level), single photon emission computed tomography (SPECT), and diagnostic facet injection. Twenty patients (74%) responded to a postoperative telephone survey. RESULTS: For general outcome measures, 85% of patients reported satisfaction with pain relief and surgical result. Ninety-five percent stated they would repeat the procedure; 85% manifested improvement in Prolo score. CONCLUSIONS: Surgical treatment of chronic axial neck pain, when preceded by thorough evaluation, can yield excellent clinical results.
Asunto(s)
Dolor de Cuello/cirugía , Satisfacción del Paciente , Adulto , Anciano , Femenino , Humanos , MMPI , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Dolor de Cuello/diagnóstico por imagen , Periodo Posoperatorio , Radiografía , Estudios Retrospectivos , Tomografía Computarizada de Emisión de Fotón ÚnicoRESUMEN
In contemporary clinical practice, the prevalence of neck pain in the general population is approximately 15%. The challenge for the primary care specialist is to be able to recognize the more serious disorders that require early referral. Additionally, it is important to have the confidence to institute specific treatment for nonurgent conditions in order to avoid unnecessary referral of patients with generally self-limiting conditions.CERVICAL SPONDYLOSIS IS A GENERAL AND NONSPECIFIC TERM THAT ENCOMPASSES A BROAD SPECTRUM OF AFFLICTIONS BUT, FOR PURPOSES OF CLARITY, CAN BE ORGANIZED INTO THREE CLINICAL SYNDROMES: Type I Syndrome (Cervical Radiculopathy); Type II Syndrome (Cervical Myelopathy); and Type III Syndrome (Axial Joint Pain). It is important to remember that shoulder problems can masquerade as cervical problems, and vice versa (e.g. adhesive capsulitis, recurrent anterior subluxation, impingement syndrome, rotator cuff tear, etc.). A number of management options, including pharmaceutical, physical therapy, and psychological therapies, are available once a diagnosis has been made.
RESUMEN
OBJECT: Although synovial cysts commonly involve the joints of the extremities, they are also found in the spinal canal. When symptomatic, they produce signs and symptoms consistent with nerve root and spinal cord compression. In this report the authors review the clinical presentations, radiological studies, and operative findings in 28 patients with intraspinal synovial cysts treated surgically at the Ochsner Clinic between 1988 and 1998. METHODS: The medical records and radiological studies obtained in 28 patients (31 intraspinal synovial cysts) were analyzed. Twenty-nine (94%) of the cysts were located in the lumbar, one in the thoracic (T8-9), and one in the cervicothoracic (C7-T1) spine. Sixteen (57%) of the 28 patients presented with radicular pain. The remaining patients presented either with neurogenic claudication (25%) or with radicular pain and an associated neurological deficit (18%). Each cyst was located adjacent to a facet joint in which there was evidence of degenerative disease. CONCLUSIONS: Intraspinal synovial cysts are uncommon lesions most often found in the lumbar spine at the L4-5 level. They are invariably associated with facet degeneration and respond very well to surgical therapy.
Asunto(s)
Enfermedades de la Columna Vertebral/cirugía , Quiste Sinovial/cirugía , Adulto , Anciano , Dolor de Espalda/etiología , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Radiografía , Estudios Retrospectivos , Enfermedades de la Columna Vertebral/diagnóstico por imagen , Enfermedades de la Columna Vertebral/etiología , Quiste Sinovial/diagnóstico por imagen , Quiste Sinovial/etiología , Resultado del TratamientoRESUMEN
This 24-year-old man presented with an unusual case of a high-flow arteriovenous fistula (AVF). This lesion was similar to giant AVFs in children that have been previously described in the literature. In patients in whom abnormalities of the vein of Galen have been excluded and in whom presentation occurs after 20 years of age, a diagnosis of congenital AVF is quite unusual. The fistula in this case originated in an enlarged callosomarginal artery and drained into the superior sagittal sinus via a saccular vascular abnormality. Two giant aneurysmal dilations of the fistula were present. In an associated finding, a small falcine dural arteriovenous malformation (AVM) was also present. Arterial supply to the AVM arose from both external carotid arteries and the left vertebral artery, with drainage through an aberrant vein in the region of the inferior sagittal sinus into the vein of Galen. Craniotomy with exposure and trapping of the AVF was performed, with subsequent radiosurgical (linear accelerator) treatment of the dural AVM. Through this combination of microsurgical trapping of the AVF and radiotherapy of the dural AVM, an excellent clinical outcome was achieved.
Asunto(s)
Fístula Arteriovenosa/complicaciones , Cuerpo Calloso/irrigación sanguínea , Senos Craneales/anomalías , Duramadre/irrigación sanguínea , Aneurisma Intracraneal/complicaciones , Malformaciones Arteriovenosas Intracraneales/complicaciones , Adulto , Fístula Arteriovenosa/cirugía , Arteria Carótida Externa/anomalías , Venas Cerebrales/anomalías , Circulación Cerebrovascular , Humanos , Aneurisma Intracraneal/cirugía , Malformaciones Arteriovenosas Intracraneales/cirugía , Masculino , Microcirugia , Radiocirugia , Arteria Vertebral/anomalíasRESUMEN
Pneumocephalus is commonly seen in clinical neurosurgical practice. Typical causes include trauma, tumor, and infection. Pneumocephalus may also occur iatrogenically at the time of intracranial surgery; it is not pathological and may be seen routinely on postoperative neuroimaging. Pneumocephalus is rarely encountered in the absence of the aforementioned entities. The authors report on an elderly woman in whom spontaneous intraventricular pneumocephalus occurred because of a congenital defect in the left tegmen tympani. Eustachian tube closure and middle ear exclusion were used to obliterate the fistulous connection. This case illustrates both an unusual cause and a unique treatment for spontaneous otogenic pneumocephalus.
Asunto(s)
Oído Medio/anomalías , Oído Medio/cirugía , Neumocéfalo/etiología , Neumocéfalo/cirugía , Anciano , Enfermedades del Oído/complicaciones , Femenino , HumanosRESUMEN
Over a 22-year period, operations were performed on 263 patients for 288 primary benign tumors of major peripheral nerves. The tumors included 85 schwannomas, 197 neurofibromas, and six plexiform neurofibromas. Total removal was achieved in 83 of the 85 schwannomas, and 76 of these patients were available for follow-up evaluation. Motor function either improved or was unchanged in 87% of these patients and 85% of those with pain in the distribution of the involved nerve had either total or partial resolution of their symptoms. Of the neurofibromas, 123 occurred in 121 patients without von Recklinghausen's disease. All tumors within this group were completely excised using a fascicular approach to the tumor. Of the 99 patients available for follow-up evaluation, 90% had either improved or unchanged motor function and 88% had partial or complete resolution of pain syndromes. Fifty-nine patients with von Recklinghausen's disease had 80 tumors removed: 74 fusiform tumors (58 of which were completely removed) and six plexiform tumors. Forty-eight of the 58 patients with gross total removal of fusiform tumors were available for follow-up evaluation, of whom 83% had improved or unchanged motor function and 74% had partial or complete resolution of pain syndromes. All six patients with plexiform tumors had progression of symptoms postoperatively. One brachial plexus schwannoma recurred and was re-excised without subsequent recurrence at the 5-year follow-up evaluation. Several incompletely excised plexiform neurofibromas have recurred with a symptomatic presentation.
Asunto(s)
Vaina de Mielina , Neurilemoma/cirugía , Neurofibroma/cirugía , Neurofibromatosis 1/cirugía , Neoplasias del Sistema Nervioso Periférico/cirugía , Adulto , Femenino , Estudios de Seguimiento , Humanos , Masculino , Vaina de Mielina/patología , Neurilemoma/patología , Neurofibroma/patología , Neurofibroma Plexiforme/cirugía , Neurofibromatosis 1/patología , Dolor Postoperatorio/etiología , Neoplasias del Sistema Nervioso Periférico/patología , Reoperación , Resultado del TratamientoRESUMEN
Surgical stabilization of non-neoplastic spinal lesions with methylmethacrylate and wire remains a controversial issue. In this report we offer a method of posterior cervical arthrodesis that combines using midline wire and acrylic with a lateral bony fusion. This construct allows for immediate as well as long-term stability. The technique is simple and safe, requires no special instrumentation, and is also easily extended to include the occipital bone. Rigid postoperative external immobilization is not required.
Asunto(s)
Cementos para Huesos , Trasplante Óseo , Hilos Ortopédicos , Vértebras Cervicales/cirugía , Metilmetacrilatos , Fusión Vertebral/métodos , Adulto , Anciano , Femenino , Humanos , Masculino , Metilmetacrilato , Persona de Mediana EdadRESUMEN
How many angiograms should be obtained after subarachnoid hemorrhage if the first one fails to identify an aneurysm? We recently encountered this common clinical problem: a patient with subarachnoid hemorrhage confirmed by computed tomography required three angiograms to identify an aneurysm at the posterior communicating artery. Review of the literature reveals conflicting recommendations as to proper management of this common and sometimes perplexing problem. Decision-making must be applied on a case-by-case basis, but persistence is probably warranted when the index of suspicion is high.
Asunto(s)
Angiografía Cerebral/estadística & datos numéricos , Aneurisma Intracraneal/diagnóstico por imagen , Hemorragia Subaracnoidea/etiología , Adulto , Femenino , HumanosRESUMEN
This study evaluated the ability of Schwann cell transplants to enhance the recovery of function in injured nerves and compared the results to those produced by sural nerve grafts. Schwann cells were isolated from sciatic nerves, prelabeled with gold fluorescent dye admixed with collagen gel, and placed in resorbable collagen tubes. Twenty-four adult rats underwent severing of the bilateral sciatic nerves, with a 10-mm gap between the nerve stumps. The rats were then divided into two groups. A collagen tube with implanted Schwann cells was implanted in one leg of the Group I rats, and the contralateral leg served as a control and was repaired with a collagen tube filled with collagen gel only. The Group II animals received conduits packed with labeled Schwann cells in one leg to bridge the 10-mm gap; the contralateral leg was repaired with an autogenous sural nerve graft. Recovery of function was assessed physiologically and morphologically. Nerve conduction velocity and nerve action potential amplitude measurements showed that the Schwann cell implants induced return of function comparable to that of the sural nerve grafts. Morphological assessments of myelination suggested a tendency toward greater numbers of myelinated axons in Schwann cell implants than in sural nerve grafts. Anatomical analyses of gold fluorescent dye showed both high viability of prelabeled Schwann cells at 120 days after transplantation and migration as far as 30 mm away from the implant site.
Asunto(s)
Regeneración Nerviosa , Células de Schwann/fisiología , Nervio Ciático/fisiología , Animales , Conducción Nerviosa , Ratas , Ratas Sprague-Dawley , Células de Schwann/trasplante , Nervio Ciático/citologíaRESUMEN
Twelve rabbits were used to study functional nerve regeneration through macropore, semipermeable, and nonpermeable collagen conduits. Each animal underwent a 10-mm bilateral resection of posterior tibial nerve. Lesions were repaired with a macropore collagen tube in one leg, and with a semipermeable or a nonpermeable collagen tube contralaterally. Functional nerve regeneration was evaluated at 6 and 12 weeks post-repair periods. Functional recovery was assessed by electrophysiologic analysis of nerve conduction velocity, amplitude of nerve action potential, amplitude and area of muscle action potential, and by quantitative and qualitative histologic analysis of myelinated nerve fibers from the distal nerve stumps. The macropore-collagen-tube group showed significantly greater functional recoveries than semipermeable or nonpermeable collagen-tube groups, based on electrophysiologic and histologic analyses.
Asunto(s)
Regeneración Nerviosa/fisiología , Nervios Periféricos/cirugía , Animales , Colágeno , Nervios Periféricos/citología , Permeabilidad , Prótesis e Implantes , ConejosRESUMEN
A 27-year-old woman in the second trimester of pregnancy presented with bitemporal hemianopsia. Total resection of a craniopharyngioma restored normal vision, and she delivered a normal infant at term. Permanent hormonal replacement therapy was not needed. Subsequent spontaneous pregnancy and delivery indicate that fertility was preserved. Literature review shows this case to be unique. Even with new developments in stereotactic radiotherapy, total excision remains a potentially achievable surgical goal.
Asunto(s)
Craneofaringioma/fisiopatología , Fertilidad , Neoplasias Hipofisarias/fisiopatología , Complicaciones Neoplásicas del Embarazo/fisiopatología , Adulto , Craneofaringioma/cirugía , Femenino , Humanos , Neoplasias Hipofisarias/cirugía , Embarazo , Complicaciones Neoplásicas del Embarazo/cirugíaRESUMEN
This report discusses the authors' technique in performing anterior cervical vertebrectomy and interbody fusion for multilevel cervical disease. The technique is performed with a high-speed drill and bone-bank fibular strut graft. After decompression of the cervical canal, ledges are made in the intact vertebral bodies to create a rectangular bed for safe seating of the bone graft. The bone-bank fibular strut graft is a feasible alternative to autograft. The simplified and safe nature of this procedure reduces postoperative morbidity as well as the length of hospital stay.
Asunto(s)
Vértebras Cervicales/cirugía , Fusión Vertebral/métodos , Trasplante Óseo/métodos , Humanos , Disco Intervertebral/cirugíaRESUMEN
Electrophysiological studies were used to evaluate neurological recovery in 14 rhesus monkeys with different nerve lesion lengths and graft lengths. After exposure of both sciatic nerves in each animal, baseline evoked nerve action potentials, muscle action potentials, and muscle strength values were determined for the posterior tibial nerves. Each nerve was then crushed over a measured distance. Three weeks later, the crushed segments were resected and the defects repaired with sural nerve grafts. In seven animals, 20-mm resection sites were repaired by 4 x 20-mm grafts in one leg and by 4 x 40-mm grafts contralaterally. In the other seven animals, the lengths of resection sites were 10 mm in one leg and 30 mm contralaterally; both nerve defects in these animals were repaired by 4 x 30-mm grafts. Electrophysiological studies were repeated at one interval of either 4, 7, or 12 months after repair. Postoperative electrophysiological values were compared to baseline values and described by the mean values and by percent recovery. Muscle strength recovery was significantly better in limbs with short lesions. In animals with identical lesion lengths, lesions repaired with shorter grafts (the same length as the defect) did significantly worse than did lesions repaired with longer grafts. This may suggest that any degree of tension at the graft repair site has a deleterious effect on functional nerve regeneration. Nevertheless, it was generally found that nerve lesion length had the greatest negative effect on functional nerve regeneration.
Asunto(s)
Regeneración Nerviosa/fisiología , Nervio Sural/trasplante , Nervio Tibial/lesiones , Nervio Tibial/cirugía , Potenciales de Acción/fisiología , Animales , Macaca mulatta , Contracción Muscular/fisiología , Conducción Nerviosa/fisiología , Nervio Tibial/fisiopatologíaRESUMEN
Cerebral amyloid angiopathy is recognized as an important cause of spontaneous intracerebral hemorrhage in the elderly normotensive patient. Magnetic resonance (MR) imaging characteristics of this disease entity are rarely mentioned in the literature. The MR imaging findings of an elderly normotensive patient presenting with an acute spontaneous intracerebral hemorrhage secondary to amyloid angiopathy are reported and a brief review of amyloidosis is presented.
Asunto(s)
Amiloidosis/diagnóstico , Encéfalo/patología , Trastornos Cerebrovasculares/diagnóstico , Anciano , Amiloidosis/clasificación , Diagnóstico Diferencial , Femenino , Humanos , Imagen por Resonancia MagnéticaRESUMEN
This experiment evaluated the electrical and histologic differences between two groups of rats, one of which underwent same-length bilateral resection of posterior tibial nerves prior to being repaired with grafts of different lengths, while the other group underwent different-length resections with same-length graft repair. In this rat model, 18 animals were used and divided into two groups. The first group of animals underwent bilateral resection of 8-mm segments of posterior tibial nerve. To repair these nerves, one leg received two 8-mm sural nerve grafts (Group A), while the other leg received two 16-mm sural nerve grafts (Group B). The second group of rats underwent posterior tibial nerve resections of 8 mm and 16 mm, respectively. The leg with the 8 mm of posterior tibial nerve resected, received two side-by-side 16-mm sural nerve grafts (Group C); the other leg with 16 mm resected, received two 16-mm sural nerve grafts (Group D). Electrophysiologic comparison of nerve conduction velocity for Groups A and B showed a significant difference (p less than 0.05), as did the same comparison for Groups C and D (p less than 0.05). Histologic studies showed that Groups A and D had marked extrafascicular escape of the regenerating nerve axons, disorganizational growth of minifascicles, and loss of integrity of the donor fascicles, while Groups B and C had very minimal extrafascicular escape of regenerating axons.(ABSTRACT TRUNCATED AT 250 WORDS)
Asunto(s)
Nervio Sural/trasplante , Nervio Tibial/cirugía , Potenciales de Acción , Animales , Axones/patología , Axones/fisiología , Electromiografía , Potenciales Evocados , Músculos/inervación , Músculos/fisiología , Regeneración Nerviosa/fisiología , Conducción Nerviosa , Ratas , Ratas Endogámicas , Tiempo de Reacción , Nervio Ciático/patología , Nervio Ciático/fisiopatología , Nervio Sural/patología , Nervio Tibial/patologíaRESUMEN
The authors have developed and patented a neurosurgical retractor system incorporating an infrared emitter and detector that allows detection of cerebral pulsations. Gentle contact with the surface of cat brains shows cerebral pulsations that correlate with arterial pulse as well as mechanical ventilation. The amplitude of cerebral pulsations decreases with higher retraction pressure and disappears at approximately 20 mmHg. The pressure on the surface of the brain decreased 50% in 5 minutes even though the position of the retractor was maintained constant. The authors postulate that monitoring cerebral pulsation may prove useful in clinical neurosurgery with respect to avoiding excessive retraction, which causes brain damage.
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Isquemia Encefálica/prevención & control , Complicaciones Intraoperatorias/prevención & control , Neurocirugia/instrumentación , Animales , Isquemia Encefálica/etiología , Gatos , Circulación Cerebrovascular/fisiología , Monitoreo Fisiológico , Instrumentos QuirúrgicosRESUMEN
Using quantitative autoradiography, we investigated the entry over 90 min of [14C]methotrexate (MTX) into C6 gliomas implanted bilaterally into Wistar rat brains. The [14C]MTX was administered into the right carotid artery, yielding ipsilateral "arterial" brain and tumor concentrations and contralateral "systemic" concentrations. In a separate group of tumor-bearing rats, mannitol 1.6 M was given into the right carotid artery prior to administering the [14C]MTX to disrupt the blood-brain barrier on the ipsilateral side. [14C]MTX tissue concentrations were measured in regions of 50 x 50 x 20 microns in tumor, peritumoral brain tissue (brain adjacent to tumor), and cerebral cortex. In the nonmannitol experiments, tissue concentrations from the rats at each time interval were fitted using a nonlinear curve fitting program, and the pharmacokinetic values of influx and efflux of [14C]MTX into the three compartments were calculated. The influx rate constant K1 for [14C]MTX ranged from 1.3 to 8.2 microliters/g/min in the tumor. Influx rate constants in the cortex were 1.3-1.9 microliters/g/min and in the brain adjacent to tumor were 1.7-2.8 microliters/g/min. The efflux rate constant k2 was approximated for each tissue but was less reliable than the K1 values. The k2 for tumor, brain adjacent to tumor, and cortex was always higher than the corresponding K1. Peak [14C]MTX concentrations in the tumor were highest after arterial infusion with hyperosmolar barrier disruption, lower after arterial administration without barrier modification, and lowest after systemic administration. However, cortical [14C]MTX concentration was also highest after arterial administration with barrier modification and higher than the highest tumor concentration. Furthermore, tissue exposure (concentration x time) was also highest in the cortex after barrier disruption. The [14C]MTX concentration x time (micrograms/min/g x 90 min +/- SEM) ratio between tumor and cortex after systemic administration was 33.4 +/- 4.1:15.7 +/- 1.9; after arterial administration it was 96.3 +/- 11.7:30.3 +/- 3.1; after arterial administration with barrier disruption it was 266.6 +/- 28.8:311.2 +/- 15.9. The greatest tumor:cortex ratio (3.1:1) occurred with arterial drug administration without barrier disruption. Disrupting the barrier enough to permit increased tumor exposure actually increased cortical exposure to a greater degree. The resulting poorer therapeutic ratio would not appear to support this technique in humans, at least for neurotoxic drugs.
Asunto(s)
Barrera Hematoencefálica , Neoplasias Encefálicas/metabolismo , Glioma/metabolismo , Metotrexato/farmacocinética , Animales , Arterias Carótidas , Inyecciones Intraarteriales , Masculino , Metotrexato/administración & dosificación , Ratas , Distribución TisularRESUMEN
The quadrilateral space syndrome is a recently established entity with seemingly consistent pathological and radiographic features. An example of this syndrome is reported. In this patient, entrapment of the axillary nerve by fibrous bands in the quadrilateral space caused shoulder pain with paresthesias in the upper extremity. Subclavian angiography provided the diagnosis by demonstrating that the posterior humeral circumflex artery, which was normal when the arm was in a neutral position, was occluded when the arm was abducted and externally rotated. Axillary neurolysis through a posterior approach resulted in relief of symptoms.
Asunto(s)
Axila/inervación , Síndromes de Compresión Nerviosa/cirugía , Adulto , Constricción Patológica/cirugía , Femenino , Humanos , Húmero/irrigación sanguíneaRESUMEN
Using quantitative autoradiography, we investigated the effect of intracarotid infusions of hyperosmolar mannitol solutions on capillary permeability and blood flow. Capillary permeability, expressed in terms of a blood-to-tissue transfer constant (K), was determined in two rat brain tumor models by measuring the entry of 14C-alpha aminoisobutyric acid into brain tumor, into brain tissue adjacent to tumor, and into cortex. Cerebral blood flow was determined by measuring the uptake of 14C-iodoantipyrine in one rat brain tumor model. Blood flow was examined in the same regions as K, as well as in the corpus callosum. Before mannitol administration, K values in both Walker 256 (W256) carcinosarcoma and C6 gliomas were much higher than those in cortex. C6 gliomas were about three times more permeable than were W256 tumors. There was a direct correlation between tumor size and increased capillary permeability. Mannitol at a concentration of 1.37 M did not increase the K values for either tumor or adjacent tissue. At 1.6 M, mannitol increased the K values for both tumors (1.7-fold in C6 glioma and 13-fold in W256) as well as for adjacent tissue. At both concentrations, mannitol markedly increased cortical K values in all groups: by 48- to 72-fold at 1.37 M and by 90- to 105-fold at 1.6 M. The net effect of the mannitol was to reverse the tumor-to-cortex permeability relationship. Cortical blood flow increased modestly after intracarotid mannitol administration on both sides of the brain. These data provide little justification for using intracarotid mannitol during chemotherapy of human brain tumors.
Asunto(s)
Barrera Hematoencefálica/efectos de los fármacos , Neoplasias Encefálicas/irrigación sanguínea , Permeabilidad Capilar/efectos de los fármacos , Carcinosarcoma/irrigación sanguínea , Circulación Cerebrovascular/efectos de los fármacos , Glioma/irrigación sanguínea , Manitol/farmacología , Animales , Neoplasias Encefálicas/secundario , Carcinosarcoma/secundario , Arterias Carótidas , Corteza Cerebral/irrigación sanguínea , Inyecciones Intraarteriales , Masculino , Concentración Osmolar , Ratas , Ratas Endogámicas , Flujo Sanguíneo Regional/efectos de los fármacosRESUMEN
The viability of debris containing C6 rat tumor cells generated by the CO2 laser was investigated using standard tissue culture techniques. No evidence of cell viability was found in the plume of laser smoke.