[Determination of the threshold and maximum non-effective concentrations of atmospheric pollutions based on individual diagnostic assessment of the status of the body]. / Opredelenie porogovykh i maksimalnykh neéffektivnykh kontsentrateii atmosfernykh zagriaznenii na osnove individualnoi diagnosticheskoi otsenko statusa organizma.

A method for determination of threshold and maximal noneffective concentrations in atmospheric air based on individual diagnostic characteristic of organism status is suggested. Comparative analysis of the main toxicometric parameters determined with the help of individual functional indices is made.

[Use of the "exposure level-body condition" relations for evaluation of the effects of complex atmospheric pollution]. / Ispol'zovanie zavisimosti "kontsentratsiia-status organizma" dlia otsenki vozdeistviia kompleksa atmosfernykh zagriaznenii.

Criteria for the organism status arrangement in terms of environmental effects expression from adaptation to its break-down were worked up. The criteria may be used in developing of the hygienic standardization of environmental effects.

[Toxicologic evaluation of nitrates entering the body with plant products]. / Toksikologicheskaia otsenka nitratov, postupaiushchikh v organizm s rastitel'nymi produktami.

An acute toxicological experiment on rats has been performed. During 30 days the animals got nitrates with water and vegetable food. The activity of glucoso-6-phosphatase, malate dehydrogenase, beta-galactosidase, the content of N-acetylneuraminic acid was determined in liver, kidney and blood serum; the level of methemoglobin in blood was estimated. It was found that the changes of studied indexes are less expressed during nitrate introduction with food than with water; on the level of minimum concentrations the changes in non-specific symptom-complex were more expressed. The maximum innocuous intake of nitrates with vegetables is 500 mg in 24 hours taking into consideration the average weight of an individual (50 kg).

[Effect of phenobarbital on the cytogenetic activity of cyclophosphamide]. / Vliianie fenobarbitala na tsitogeneticheskuiu aktivnost' tsiklofosfamida.

The effect of phenobarbital (PB, 2 and 80 mg/kg, 3 intraperitoneal injections) on the rate of chromosomal aberrations in the bone marrow cells of rats induced by a single intraperitoneal injection of cyclophosphamide (CP) in a dose of 25 mg/kg was studied. Activity of mixed function oxygenase (MFO) was evaluated from the content of cytochrome P450, b5 and activity of aniline hydroxylase. The rate of the cells with chromosomal aberrations in the bone marrow after combined action of PB and CP did not depend on the PB dose and was significantly higher as compared with CP action alone. After injection of 2 mg/kg, PB activity of MFO did not differ from that in control and increased 2 times after 80 mg/kg. Combined action of PB and CP did not induce any significant changes in activity of MFO compared with PB alone.