Apparent Diffusion Coefficient (ADC) predicts therapy response in pancreatic ductal adenocarcinoma.

Recent advances in molecular subtyping of Pancreatic Ductal Adenocarcinoma (PDAC) support individualization of therapeutic strategies in this most aggressive disease. With the emergence of various novel therapeutic strategies and neoadjuvant approaches in this quickly deteriorating disease, robust approaches for fast evaluation of therapy response are urgently needed. To this aim, we designed a preclinical imaging-guided therapy trial where genetically engineered mice harboring endogenous aggressive PDAC were treated with the MEK targeting drug refametinib, which induces rapid and profound tumor regression in this model system. Multi-parametric non-invasive imaging was used for therapy response monitoring. A significant increase in the Diffusion-Weighted Magnetic Resonance Imaging derived Apparent Diffusion Coefficient (ADC) was noted already 24 hours after treatment onset. Histopathological analyses showed increased apoptosis and matrix remodeling at this time point. Our findings suggest the ADC parameter as an early predictor of therapy response in PDAC.

[Sport climbing with adolescents: effect on spine stabilising muscle strength]. / Klettertraining bei Jugendlichen: Erfolge für die wirbelsäulenstabilisierende Muskulatur.

Indoor climbing and boulder facilities gain importance in therapy for patients with back pain or with psychic disorders. The effect of climbing on strength of the spine musculature has hardly been investigated in young men and women. To address this question 17 high school students agreed to enrol into a 10-week climbing course twice a week and 9 to serve as controls. All participants were measured before and after training on special devices for measuring the isometric strength of cervical extensors and lateral flexors as well as for thoracic/lumbal spine, the flexors, extensors, the right and left rotators and lateral flexors. The mobility was measured for the transversal and frontal plane. After the climbing course, a gain in strength was measured in all but two muscle groups, the thoracic/lumbal extensors and left lateral flexors, in the control group only for the thoracic/lumbal flexors and left lateral flexors. The gain in strength was higher in the climbing group. The ratio of maximal strength of the right to left rotators was smaller after climbing. Sport climbing in adolescence leads to increased muscle strength of the spine muscles and to an increased muscular balance; thus, for prevention of back pain climbing courses may be introduced in high schools.

Dural arteriovenous fistulae causing pseudotumour cerebri syndrome in an elderly man.

The clinical presentation of dural arteriovenous fistulae (DAVF) is dependent on their location and the nature of their venous drainage. The latter plays a critical part in determining whether or not the fistula gives rise to intracranial hypertension, which is present in only a minority of cases. We present a case of the pseudotumour cerebri syndrome in an elderly man with bilateral intracranial DAVF supplied by the occipital arteries. Cerebral angiography was required for definitive diagnosis, and to characterise the abnormal venous drainage. The pathophysiology of intracranial hypertension in DAVF is discussed.

Cell growth in a pinned soap froth.

Experimental kinetic data on soap froth cell growth in a random array of fixed pinning centers is reported. The scaling of our two-dimensional data is analyzed and compared with pinning-free growth. The obtained data agree fairly well with a proposed cell growth law. We also discuss the relationship between the pin concentration and the final cell size.