Usefulness of central venous oxygen saturation monitoring during bidirectional Glenn shunt.

A PediaSat™ oximetry catheter (PediaSat: Edwards Lifesciences Co., Ltd., Irvine, CA, U. S. A.), which facilitates continuous measurement of central venous oxygen saturation (ScvO2), may be useful for surgery for pediatric congenital heart disease. We used PediaSat during a bidirectional Glenn shunt. The patient was a 13-month-old boy. Under a diagnosis of left single ventricle (pulmonary atresia, right ventricular hypoplasia, atrial septal defect) and residual left aortic arch/left superior vena cava, a modified right Blalock-Taussig shunt was performed. Cyanosis deteriorated, so a bidirectional Glenn shunt was scheduled. After anesthesia induction, a 4.5 Fr double-lumen (8 cm) PediaSat was inserted through the right internal jugular vein for continuous ScvO2 monitoring. Furthermore, the probe of a near-infrared, mixed blood oxygen saturation-measuring monitor was attached to the forehead for continuous monitoring of the regional brain tissue mixed blood oxygen saturation (rSO2) (INVOS™ 5100C, Covidien; Boulder, CO, U. S. A.). Blockage of the right pulmonary artery and right superior vena cava decreased the oxygen saturation, ScvO2, and rSO2, but increased the central venous pressure. Although changes in ScvO2 were parallel to those in rSO2, the former showed more marked changes. A combination of ScvO2 and rSO2 for monitoring during Glenn shunt may be safer.

Recent less-invasive circulatory monitoring during renal transplantation.

For anesthetic management during renal transplantation, it is necessary to maintain the blood flow and function of the transplanted kidney by performing massive fluid management and stabilizing blood pressure. We report anesthetic management for renal transplantation with a less-invasive circulatory monitoring system (Edwards Life Sciences Co., Ltd., Irvine, California, U.S.A.). In November 2010, renal transplantation was started in our hospital, and performed in 6 patients. In the first patient, fluid/circulatory management was conducted by connecting a standard arterial line and a standard central venous (CV) line. In the second patient, a FloTrac(TM) system and a standard CV line were used. In the third patient, a standard arterial line and a PreSep(TM) CV Oximetry Catheter were used. In the fourth and fifth patients, a FloTrac(TM) and a PreSep(TM) were used. In the latest patient, FloTrac(TM) and PreSep(TM) were connected to an EV1000(TM) Clinical Platform for fluid/circulatory management. The establishment of high-visibility monitors was useful for evaluating the condition and confirming the effects. As there are marked changes in hemodynamics, the CV pressure, which has been used as a parameter of fluid management, is not reliable in renal failure patients with a high incidence of cardiovascular complications. Advances in noninvasive circulatory monitoring with dynamic indices may improve the safety of anesthetic management during renal transplantation.

[Transient paraplegia due to epidural hematoma after catheter withdrawal].

A 58-year-old man with hypertension underwent laparoscopic distal gastrectomy under general and epidural anesthesia. Preoperative laboratory date revealed a normal platelet count and normal coagulation profile. Epidural puncture was successfully performed at the T9-10 intervertebral space on the first attempt without bleeding. An epidural catheter was smoothly inserted 5 cm cephalad. On the third postoperative day, paraplegia due to thoracic epidural hematoma developed shortly after extraction of the catheter. At that time, his blood pressure was 190/102 mmHg because of a pain due to walk. On using a hypotensive drug, his blood pressure fell. Ten minutes later, paraplegia disappeared spontaneously. It is suggested that the spinal cord of the patient was subjected to transient pressure hematoma. A decline in blood pressure may have caused the blood to spread through the epidural space, such that the neurologic symptoms disappeared.

A case where rocuronium was unable to achieve neuromuscular block immediately after sugammadex administration.

We present a case where immediate muscle relaxation was needed following sugammadex administration. A 72 year-old female underwent surgery for a cerebral artery aneurysm. Upon conclusion of the operation sugammadex (9.3 mg/kg) was administered and the patient was noted to have left hemiplegia. Rocuronium (1.2 mg/kg × 2 doses) was given in order to gain neuromuscular block approximately 25 minutes after sugammadex had been injected. Although TOF monitoring was not utilized in this case and assessing residual muscular block was difficult, spontaneous respirations continued and breathing had to be controlled with sevoflurane and remifentanil. Sugammadex is a potent reversal agent for rocuronium-induced neuromuscular block, however, certain situations require immediate neuromuscular blockade following sugammadex. In this case, rocuronium was unable to induce neuromuscular blockade immediately after sugammadex and that higher concentrations were necessary in addition to intravenous analgesics and inhaled anesthetics.

[Comparative study of sublingual midazolam with oral midazolam for premedication in pediatric anesthesia].

BACKGROUND: We studied the efficacy of sublingual midazolam compared with oral midazolam for predmedication in children. METHODS: Forty-two children (9 months-11 years of age) for minor elective surgery were divided into 2 groups; one group treated with sublingual midazolam at 30 minutes before the entrance into operating room, and the other group receiving oral midazolam at 30 minutes before entering operating room. The group treated with sublingual midazolam at 30 minutes received sublingual midazolam 0.2 mg x kg(-1), while the other group received oral midazolam 0.5 mg x kg(-1) with syrup. We evaluated the taste acceptability, the effect of sedation, the anxiolysis and the cooperation for mask acceptance by using scales. RESULTS: Twenty children accepted sublingual midazolam, and twenty-one accepted oral midazolam. It was effective and satisfactory in taste acceptability, sedation, anxiolysis and cooperation in both groups. There was no difference between the two groups. Any respiratory depression and delayed recovery were not observed. CONCLUSIONS: Sublingual midazolam 0.2 mg x kg(-1) is useful for premedication in pediatric anesthesia, and it equals with oral midazolam 0.5 mg x kg(-1) in efficacy.

[Gastric fluid volume and pH in scheduled surgical patients following unrestricted oral fluid intake until two hours before surgery].

BACKGROUND: In scheduled surgery, drinking is generally restricted for 6-8 hours before operation to avoid aspiration pneumonia induced by aspiration of residual gastric contents. However, the restriction is hard for patients and also there is no evidence of reduction of such a risk. We examined the correlation between water intake and residual gastric content. METHODS: We studied 60 patients scheduled for gynecological operations (ASA 1 or 2). They were allowed to drink clear water freely until two hours before operation, and timing and volume of their drinking were recorded. In addition, volume and pH of the residual gastric content were measured at induction of anesthesia. RESULTS: The mean volumes of fluids they had are 157 ml (range 0-750 ml) in the morning, and 486 ml (range 80-1300 ml) in the afternoon. The patients took more water as the scheduled time of operation became nearer. There was no correlation between the volume of preoperative drinking with the volume and pH of gastric content. CONCLUSIONS: Intake of clear water until two hours before surgery has been shown to be safe and contribute to patients' satisfaction.