RESUMEN
The effect on weight reduction of fish oil combined with food restriction in comparison with that of beef tallow was investigated in high-fat diet-induced obese KKAy mice. Although the reduction of body and white adipose tissue weight was similar in the two groups, fish oil increased adiponectin levels in the plasma, improved dyslipidemia accompanied by suppression of lipid synthesis in the liver when compared with beef tallow.
Asunto(s)
Grasas de la Dieta/administración & dosificación , Dislipidemias/tratamiento farmacológico , Grasas/farmacología , Aceites de Pescado/farmacología , Adiponectina/sangre , Tejido Adiposo Blanco/efectos de los fármacos , Tejido Adiposo Blanco/metabolismo , Animales , Peso Corporal/efectos de los fármacos , Bovinos , Dieta Alta en Grasa , Dislipidemias/sangre , Dislipidemias/etiología , Hígado/efectos de los fármacos , Hígado/metabolismo , Ratones , Ratones Obesos , Pérdida de Peso/efectos de los fármacosRESUMEN
We investigated whether oral administration of palmitoleate ameliorates disorders of lipid metabolism to clarify the effects of one of the components of fish oil. Lipid levels in the liver and plasma were significantly decreased by palmitoleate and by EPA administration. These results suggest that palmitoleate, in addition to EPA, plays a role in the regulation of lipid metabolism by fish oil.
Asunto(s)
Dieta Alta en Grasa/efectos adversos , Ácido Eicosapentaenoico/farmacología , Ácidos Grasos Monoinsaturados/farmacología , Metabolismo de los Lípidos/efectos de los fármacos , Administración Oral , Animales , Peso Corporal/efectos de los fármacos , Ácido Eicosapentaenoico/administración & dosificación , Ingestión de Energía/efectos de los fármacos , Ácidos Grasos Monoinsaturados/administración & dosificación , Masculino , Ratones , Ratones Endogámicos C57BLRESUMEN
BACKGROUND: Fish oil is known to improve lifestyle-related diseases. These effects occur partly via activation of PPARs by the n-3 polyunsaturated fatty acids included abundantly in fish oil. We investigated fish oil functions on glucose and lipid metabolism that are both dependent on and independent of PPARs pathway. METHODS: Mice were fed a diet containing 30 en% beef tallow (B diet) for twelve weeks to induce obesity. The mice were then divided into two groups which were fed either a B diet or a diet containing 30 en% fish oil (F diet). Each group was further divided into two groups which were administered PPARα and γ antagonists or vehicle once a day for three weeks. RESULTS: The F diet groups showed lower triglyceride levels in plasma and liver than the B diet groups, but PPARs antagonists did not affect the triglyceride levels in either diet groups. The F diet groups also showed improvement of glucose tolerance compared with the B diet groups. However, PPARs antagonists made glucose tolerance worse in the F diet group but improved it in the B diet group. Therefore, by the administration of antagonists, glucose tolerance was inversely regulated between the B and F diets, and hypolipidemic action in the plasma and liver of the F diet group was not affected. CONCLUSION: These results suggest that fish oil decreases lipid levels in plasma and liver via PPARs pathway-independent mechanism, and that glucose tolerance is inversely regulated by PPARs antagonists under diets containing different oils.
