RESUMEN
Metal sulfides have attracted tremendous research interest for developing high-performance electrodes for potassium-ion batteries (PIBs) for their high theoretical capacities. Nevertheless, the practical application of metal sulfides in PIBs is still unaddressed due to their intrinsic shortcomings of low conductivity and severe volume changes during the potassiation/depotassiation process. Herein, robust Fe7S8/C hybrid nanocages reinforced by defect-rich MoS2 nanosheets (Fe7S8/C@d-MoS2) were designed, which possess abundant multichannel and active sites for potassium-ion transportation and storage. Kinetic analysis and theoretical calculation verify that the introduction of defect-rich MoS2 nanosheets dramatically promotes the potassium-ion diffusion coefficient. The ex-situ measurements revealed the potassium-ion storage mechanism in the Fe7S8/C@d-MoS2 composite. Benefitting from the tailored structural design, the Fe7S8/C@d-MoS2 hybrid nanocages show high reversible capacity, exceptional rate property, and superior cyclability.
RESUMEN
MicroRNA-203 (miR-203), possessing tumor suppressive or promotive activities, has been found to be downregulated or upregulated in different cancer types. The purpose of this study was to investigate whether the increased expression of miR-203 can be used as a noninvasive diagnostic and prognostic biomarker in epithelial ovarian cancer (EOC). Real-time quantitative PCR was performed to detect the expression levels of miR-203 in EOC tissues. The expression levels of miR-203 were significantly higher in EOC tissues compared to adjacent non-cancerous tissues (p < 0.001). High expression of miR-203 was observed in 65.38 % (102/156) of EOC. In addition, high miR-203 expression was found to be closely correlated with advanced FIGO stage (p < 0.001), higher histological grade (p = 0.02), lymph node involvement (p < 0.001), and positive recurrence (p < 0.001). Moreover, high miR-203 expression was correlated with shorter overall survival (p < 0.001) and shorter progression-free survival (p < 0.001) of EOC patients. Furthermore, multivariate analysis showed that the status of miR-203 expression was an independent predictor for both overall survival and progression-free survival in EOC. These findings provide the convincing evidence for the first time that the upregulation of miR-203 may serve as a novel molecular marker to predict the aggressive tumor progression and unfavorable prognosis of EOC patients.