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1.
Braz J Microbiol ; 52(4): 2063-2068, 2021 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-34218427

RESUMEN

Pulmonary mucormycosis and aspergillosis with disseminated mucormycosis involving gastrointestinalin is a very rare but lethal infection leading to extreme mortality. Herein, we present a unique case of pulmonary coinfection with Cunninghamella bertholletiae and Aspergillus flavus, with disseminated mucormycosis involving the jejunum caused by C. bertholletiae in an acute B-lymphocytic leukemia (B-ALL) patient with familial diabetes. Early administration of active antifungal agents at optimal doses and complete resection of all infected tissues led to improved therapeutic outcomes.


Asunto(s)
Coinfección , Cunninghamella , Enfermedades Pulmonares , Mucormicosis , Leucemia-Linfoma Linfoblástico de Células Precursoras , Aspergilosis Pulmonar , Antifúngicos/uso terapéutico , Cunninghamella/fisiología , Femenino , Humanos , Enfermedades Pulmonares/microbiología , Persona de Mediana Edad , Mucormicosis/complicaciones , Mucormicosis/diagnóstico , Mucormicosis/tratamiento farmacológico , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicaciones , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico , Aspergilosis Pulmonar/complicaciones , Resultado del Tratamiento
2.
Brain Res ; 1727: 146558, 2020 01 15.
Artículo en Inglés | MEDLINE | ID: mdl-31794706

RESUMEN

BACKGROUND AND PURPOSE: Epilepsy is one of the most common diseases of the nervous system. Approximately one-third of epilepsy cases are drug-resistant, among which generalized-onset seizures are very common. The present study aimed to analyze abnormalities of the thalamocortical fiber pathways in each hemisphere of the brains of patients with drug-resistant generalized epilepsy. MATERIALS AND METHODS: The thalamocortical structural pathways were identified by diffusion tensor imaging (DTI) in 15 patients with drug-resistant generalized epilepsy and 16 gender/age-matched controls. The thalami of both groups were parcellated into subregions according to the local thalamocortical connectivity pattern. DTI measures of thalamocortical connections were compared between the two groups. RESULTS: Probabilistic tractography analyses showed that fractional anisotropy of thalamocortical pathways in patients with epilepsy decreased significantly, and the radial diffusivity of the left thalamus pathways with homolateral motor and parietal-occipital cortical regions in the drug-resistant epilepsy group increased significantly. In addition to the right thalamus pathway and prefrontal cortical region, fractional anisotropy of all other pathways was inversely correlated with disease duration. CONCLUSION: The results provide evidence indicating widespread bilateral abnormalities in the thalamocortical pathways in epilepsy patients and imply that the degree of abnormality in the pathway increases with the disease duration.


Asunto(s)
Corteza Cerebral/patología , Epilepsia Refractaria/patología , Epilepsia Generalizada/patología , Tálamo/patología , Adulto , Anisotropía , Imagen de Difusión Tensora , Femenino , Humanos , Masculino , Vías Nerviosas/patología
3.
Genet Mol Biol ; 33(4): 605-9, 2010 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21637565

RESUMEN

In the present study, we investigated the application of 13 short tandem repeat (STR) loci (D13S317, D7S820, TH01, D16S539, CSFIPO, VWA, D8S1179, TPOX, FGA, D3S1358, D21S11, D18S51 and D5S818) routinely used in forensic analysis, for delineating population relationships among seven human populations representing the two major geographic groups, namely the southern and northern Chinese. The resulting single topology revealed pronounced geographic and population partitioning, consistent with the differences in geographic location, languages and eating habits. These findings suggest that forensic STR loci might be particularly powerful tools in providing the necessary fine resolution for reconstructing recent human evolutionary history.

4.
Genet. mol. biol ; Genet. mol. biol;33(4): 605-609, 2010. ilus, mapas, tab
Artículo en Inglés | LILACS | ID: lil-571511

RESUMEN

In the present study, we investigated the application of 13 short tandem repeat (STR) loci (D13S317, D7S820, TH01, D16S539, CSFIPO, VWA, D8S1179, TPOX, FGA, D3S1358, D21S11, D18S51 and D5S818) routinely used in forensic analysis, for delineating population relationships among seven human populations representing the two major geographic groups, namely the southern and northern Chinese. The resulting single topology revealed pronounced geographic and population partitioning, consistent with the differences in geographic location, languages and eating habits. These findings suggest that forensic STR loci might be particularly powerful tools in providing the necessary fine resolution for reconstructing recent human evolutionary history.


Asunto(s)
Humanos , Medicina Legal , Genética de Población
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