The Effectiveness Comparison of Different Acupuncture-Related Therapies on Knee Osteoarthritis: A Meta-Analysis.

Objective: This meta-analysis aims to assess the efficacy of acupuncture-related therapy on knee osteoarthritis (KOA) patients. Method: We searched PubMed, Embase, and CNKI databases to screen eligible trials between 2017 and 2022. All trials that used acupuncture/moxibustion of KOA patients were included. Study selection and data extraction were performed by 2 researchers independently. The statistics was performed by using R 4.1.1. Results: A total of 17 trials were included in our meta-analysis. Meta-analysis results showed the evidence of the relation of several common acupunture/moxibustion treatments by network meta-analysis. In the fixed effect model, acupuncture/moxibustion has superior therapy efficacy than sham treatment (mean difference = -0.34, 95% confidence interval = (-0.52,-0.16), P=0.95). In fixed effect model, specific acupuncture/moxibustion has superior therapy efficacy than usual acupuncture/moxibustion (mean difference = -0.45, 95% confidence interval = (-0.62, -0.29), P < 0.01). Conclusion: Acupuncture/moxibustion has superior therapy efficacy than sham treatment. Specific acupuncture/moxibustion has superior therapy efficacy than usual acupuncture/moxibustion.

Coactivation of gustatory and olfactory signals in flavor perception.

It is easier to detect mixtures of gustatory and olfactory flavorants than to detect either component alone. But does the detection of mixtures exceed the level predicted by probability summation, assuming independent detection of each component? To answer this question, we measured simple response times (RTs) to detect brief pulses of one of 3 flavorants (sucrose [gustatory], citral [olfactory], sucrose-citral mixture) or water, presented into the mouth by a computer-operated, automated flow system. Subjects were instructed to press a button as soon as they detected any of the 3 nonwater stimuli. Responses to the mixtures were faster (RTs smaller) than predicted by a model of probability summation of independently detected signals, suggesting positive coactivation (integration) of gustation and retronasal olfaction in flavor perception. Evidence for integration appeared mainly in the fastest 60% of the responses, indicating that integration arises relatively early in flavor processing. Results were similar when the 3 possible flavorants, and water, were interleaved within the same session (experimental condition), and when each flavorant was interleaved with water only (control conditions). This outcome suggests that subjects did not attend selectively to one flavor component or the other in the experimental condition and further supports the conclusion that (late) decisional or attentional strategies do not exert a large influence on the gustatory-olfactory flavor integration.

Taste coding after selective inhibition by chlorhexidine.

Coding of the complex tastes of ionic stimuli in humans was studied by combining taste confusion matrix (TCM) methodology and treatment with chlorhexidine gluconate. The TCM evaluates discrimination of multiple stimuli simultaneously. Chlorhexidine, a bis-biguanide antiseptic, reversibly inhibits salty taste and tastes of a subset of bitter stimuli, including quinine hydrochloride. Identifications of salty (NaCl, "salt"), bitter (quinine.HCl, "quinine"), sweet (sucrose, "sugar"), and sour (citric acid, "acid") prototypes, alone and as components of binary mixtures, were measured under 4 conditions. One was a water-rinse control and the others had the salt and quinine tastes progressively reduced by treatment with 1 mM chlorhexidine, 3 mM chlorhexidine, and ultimately to zero by elimination of NaCl and quinine.HCl. Treatment with chlorhexidine perturbed identification of salt more than quinine; both were thereafter more often confused with "water" and unidentified when mixed with sucrose or citric acid. All pairwise discriminations that depended on the tastes of NaCl and quinine.HCl deteriorated, and although H(2)O was mistakenly identified as quinine after chlorhexidine, this may have been a decisional bias. Other confusions reflected "unprompted mixture analysis" and an obscuring of salt taste by a less-inhibited stronger quinine or sugar or acid tastes in mixtures. Partial inhibition of the tastes of NaCl and quinine.HCl by chlorhexidine was considered in the context of multiple receptors for the 2 compounds. Discrimination among prototypic stimuli with varying strengths was consistent with a gustatory system that evaluates a small number of independent tastes.

Detection-theoretic analysis of same-different judgments for the amplitude discrimination of acoustic sinusoids.

Three methods were applied to determine which decision model best accounted for same-different judgments about the amplitude of acoustic sinusoids. The methods were (1) analysis of the shape of the receiver operating characteristic; (2) analysis of an observer's decision space; and (3) a correlation method based on the conditional-on-single-stimulus procedure. In one experiment, observers rated their confidence that a pair of 1-kHz sinusoids was drawn from the same or from different sets. The two sets had identical Gaussian distributions of decibel amplitudes, but their mean amplitudes differed by 3 dB. The differencing model, in which observers base their decision on the absolute difference between the two observations, accounted for the data better than the independent-observation model, in which observers compute independent likelihood ratios for each observation. A second experiment added to every trial an interval that contained a 1-kHz sinusoid whose amplitude equaled the grand mean of both stimulus sets. Despite this additional information, which is needed to adopt the independent-observation model, the differencing model again better accounted for the data.