Blood glucose to predict symptomatic intracranial hemorrhage after endovascular treatment of acute ischemic stroke with large infarct core: a prospective observational study.

Introduction: Symptomatic intracranial hemorrhage (sICH) is a serious complication of acute ischemic stroke (AIS) after endovascular treatment (EVT). Limited data exist regarding predictors and clinical implications of sICH after EVT, underscoring the significance of identifying risk factors to enhance prevention strategies. Therefore, the main objective of this study was to evaluate the incidence of sICH and identify its predictors after EVT in patients with large infarct core-AIS in the pre-circulation stage. Methods: Using data from the EVT for the Pre-circulation Large Infarct Core-AIS Study, we enrolled patients who were treated with EVT from the Prospective Multicenter Cohort Study of Early Treatment in Acute Stroke (MAGIC) registry. Baseline demographics, medical history, vascular risk factors, blood pressure, stroke severity, radiographic features, and EVT details were collected. The patients were classified into three groups: without intracranial hemorrhage (ICH), with asymptomatic intracranial hemorrhage (aICH), and sICH, based upon the occurrence of sICH. The main outcomes were the occurrence of sICH according to the Heidelberg Bleeding Classification and functional condition at 90 days. Multivariate logistic regression analysis and receiver operating characteristic (ROC) curves were used to identify independent predictors of sICH after EVT. Results: The study recruited a total of 490 patients, of whom 13.3% (n = 65) developed sICH. Patients with sICH had less favorable outcomes than those without intracranial hemorrhage (ICH) and those with aICH (13.8% vs. 43.5% vs. 32.2%, respectively; p < 0.001). The overall mortality was 41.8% (n = 205) at 90 days post-EVT. The univariate analysis revealed significant differences among the three groups in terms of blood glucose levels at admission, probability of favorable outcomes, incidence of brain herniation, and 90-day mortality. The multifactorial logistic regression analysis revealed that the blood glucose level at admission [odds ratio (OR) 1.169, p < 0.001, confidence interval (CI) 1.076-1.269] was an independent predictor of sICH. A blood glucose level of 6.95 mmol/L at admission was the best predictor of sICH, with an area under the ROC curve (AUC) of 0.685 (95% CI: 0.616-0.754). Discussion: The study findings demonstrated that the probability of sICH after EVT was 13.3% in patients with pre-circulation large infarct core-AIS, and sICH increased the risk of an unfavorable prognosis. Higher blood glucose levels at admission were associated with sICH after EVT in patients with pre-circulation large infarct core AIS. These findings underscore the importance of early management strategies to mitigate this risk.

Tighter Constraints of Multi-Qubit Entanglement in Terms of Nonconvex Entanglement Measures LCREN and LCRENoA.

The monogamy property of entanglement is an intriguing feature of multipartite quantum entanglement. Most entanglement measures satisfying the monogamy inequality have turned out to be convex. Whether nonconvex entanglement measures obey the monogamy inequalities remains less known at present. As a well-known measure of entanglement, the logarithmic negativity is not convex. We elucidate the constraints of multi-qubit entanglement based on the logarithmic convex-roof extended negativity (LCREN) and the logarithmic convex-roof extended negativity of assistance (LCRENoA). Using the Hamming weight derived from the binary vector associated with the distribution of subsystems, we establish monogamy inequalities for multi-qubit entanglement in terms of the αth-power (α≥4ln2) of LCREN, and polygamy inequalities utilizing the αth-power (0≤α≤2) of LCRENoA. We demonstrate that these inequalities give rise to tighter constraints than the existing ones. Furthermore, our monogamy inequalities are shown to remain valid for the high-dimensional states that violate the CKW monogamy inequality. Detailed examples are presented to illustrate the effectiveness of our results in characterizing the multipartite entanglement distributions.

Detecting genuine tripartite entanglement via general symmetric informationally complete measurements.

We study multipartite entanglement and genuine tripartite entanglement based on general symmetric informationally complete positive operator valued measurements (GSIC-POVMs). By representing the bipartite density matrices in terms of GSIC-POVMs, we obtain the lower bound of the sum of squares of the corresponding probability. We then construct a special matrix with the correlation probability of GSIC-POVMs to derive useful and operational criteria to detect genuine tripartite entanglement. We also generalize the results to obtain a sufficient criterion to detect entanglement for multipartite quantum states in arbitrary dimensions. Detailed examples show that the new method can detect more entangled and genuine entangled states than previous criteria.

Assisted quantum simulation of open quantum systems.

Universal quantum algorithms (UQA) implemented on fault-tolerant quantum computers are expected to achieve an exponential speedup over classical counterparts. However, the deep quantum circuits make the UQA implausible in the current era. With only the noisy intermediate-scale quantum (NISQ) devices in hand, we introduce the quantum-assisted quantum algorithm, which reduces the circuit depth of UQA via NISQ technology. Based on this framework, we present two quantum-assisted quantum algorithms for simulating open quantum systems, which utilize two parameterized quantum circuits to achieve a short-time evolution. We propose a variational quantum state preparation method, as a subroutine to prepare the ancillary state, for loading a classical vector into a quantum state with a shallow quantum circuit and logarithmic number of qubits. We demonstrate numerically our approaches for a two-level system with an amplitude damping channel and an open version of the dissipative transverse field Ising model on two sites.

Crosstalk Defect Detection Method Based on Salient Color Channel Frequency Domain Filtering.

Display crosstalk defect detection is an important link in the display quality inspection process. We propose a crosstalk defect detection method based on salient color channel frequency domain filtering. Firstly, the salient color channel in RGBY is selected by the maximum relative entropy criterion, and the color quaternion matrix of the displayed image is formed with the Lab color space. Secondly, the image color quaternion matrix is converted into the logarithmic spectrum in the frequency domain through the hyper-complex Fourier transform. Finally, Gaussian threshold band-pass filtering and hyper-complex inverse Fourier transform are used to separate the low-contrast defects and background of the display image. The experimental results show that the accuracy of the proposed algorithm reaches 96% for a variety of crosstalk defect detection. Compared with the current advanced defect detection algorithms, the effectiveness of the proposed method for low-contrast crosstalk defect detection is confirmed.

Multipartite entanglement criterion via generalized local uncertainty relations.

We study the detection of multipartite entanglement based on the generalized local uncertainty relations. A sufficient criterion for the entanglement of four-partite quantum systems is presented in terms of the local uncertainty relations. Detailed examples are given to illustrate the advantages of our criterion. The approach is generalized to general multipartite entanglement cases.

Unambiguous State Discrimination with Intrinsic Coherence.

We investigate the discrimination of pure-mixed (quantum filtering) and mixed-mixed states and compare their optimal success probability with the one for discriminating other pairs of pure states superposed by the vectors included in the mixed states. We prove that under the equal-fidelity condition, the pure-pure state discrimination scheme is superior to the pure-mixed (mixed-mixed) one. With respect to quantum filtering, the coherence exists only in one pure state and is detrimental to the state discrimination for lower dimensional systems; while it is the opposite for the mixed-mixed case with symmetrically distributed coherence. Making an extension to infinite-dimensional systems, we find that the coherence which is detrimental to state discrimination may become helpful and vice versa.

A Note on the Hierarchy of Quantum Measurement Incompatibilities.

The quantum measurement incompatibility is a distinctive feature of quantum mechanics. We investigate the incompatibility of a set of general measurements and classify the incompatibility by the hierarchy of compatibilities of its subsets. By using the approach of adding noises to measurement operators, we present a complete classification of the incompatibility of a given measurement assemblage with n members. Detailed examples are given for the incompatibility of unbiased qubit measurements based on a semidefinite program.

On Local Unitary Equivalence of Two and Three-qubit States.

We study the local unitary equivalence for two and three-qubit mixed states by investigating the invariants under local unitary transformations. For two-qubit system, we prove that the determination of the local unitary equivalence of 2-qubits states only needs 14 or less invariants for arbitrary two-qubit states. Using the same method, we construct invariants for three-qubit mixed states. We prove that these invariants are sufficient to guarantee the LU equivalence of certain kind of three-qubit states. Also, we make a comparison with earlier works.

Optimal Universal Uncertainty Relations.

We study universal uncertainty relations and present a method called joint probability distribution diagram to improve the majorization bounds constructed independently in [Phys. Rev. Lett. 111, 230401 (2013)] and [J. Phys. A. 46, 272002 (2013)]. The results give rise to state independent uncertainty relations satisfied by any nonnegative Schur-concave functions. On the other hand, a remarkable recent result of entropic uncertainty relation is the direct-sum majorization relation. In this paper, we illustrate our bounds by showing how they provide a complement to that in [Phys. Rev. A. 89, 052115 (2014)].

Maximal Holevo Quantity Based on Weak Measurements.

The Holevo bound is a keystone in many applications of quantum information theory. We propose " maximal Holevo quantity for weak measurements" as the generalization of the maximal Holevo quantity which is defined by the optimal projective measurements. The scenarios that weak measurements is necessary are that only the weak measurements can be performed because for example the system is macroscopic or that one intentionally tries to do so such that the disturbance on the measured system can be controlled for example in quantum key distribution protocols. We evaluate systematically the maximal Holevo quantity for weak measurements for Bell-diagonal states and find a series of results. Furthermore, we find that weak measurements can be realized by noise and project measurements.

Syntaxin 2 and SNAP-23 are required for regulated surfactant secretion.

The secretion of lung surfactant in alveolar type II cells is a complex process involving the fusion of lamellar bodies with the plasma membrane. This process is somewhat different from the exocytosis of hormones and neurotransmitters. For example, it is a relatively slower process, and lamellar bodies are very large vesicles with a diameter of approximately 1 microm. SNARE proteins are the conserved molecular machinery of exocytosis in the majority of secretory cells. However, their involvement in surfactant secretion has not been reported. Here, we showed that syntaxin 2 and SNAP-23 are expressed in alveolar type II cells. Both proteins are associated with the plasma membrane, and to some degree with lamellar bodies. An antisense oligonucleotide complementary to syntaxin 2 decreased its mRNA and protein levels. The same oligonucleotide also inhibited surfactant secretion, independent of secretagogues. A peptide derived from the N-terminus of syntaxin 2 or the C-terminus of SNAP-23 significantly inhibited Ca(2+)- and GTPgammaS-stimulated surfactant secretion from permeabilized type II cells in a dose-dependent manner. Furthermore, introduction of anti-syntaxin 2 or anti-SNAP-23 antibodies into permeabilized type II cells also inhibited surfactant release. Our results suggest that syntaxin 2 and SNAP-23 are required for regulated surfactant secretion.