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3.
Health Technol Assess ; 13(16): iii-iv, xi-xiii, 1-113, 137-347, 2009 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-19272272

RESUMEN

OBJECTIVES: The two objectives were: (1) to identify, appraise and synthesise research that is relevant to selected UK National Screening Committee (NSC) criteria for a screening programme in relation to partner violence; and (2) to judge whether current evidence fulfils selected NSC criteria for the implementation of screening for partner violence in health-care settings. DATA SOURCES: Fourteen electronic databases from their respective start dates to 31 December 2006. REVIEW METHODS: The review examined seven questions linked to key NSC criteria: QI: What is the prevalence of partner violence against women and what are its health consequences? QII: Are screening tools valid and reliable? QIII: Is screening for partner violence acceptable to women? QIV: Are interventions effective once partner violence is disclosed in a health-care setting? QV: Can mortality or morbidity be reduced following screening? QVI: Is a partner violence screening programme acceptable to health professionals and the public? QVII: Is screening for partner violence cost-effective? Data were selected using different inclusion/exclusion criteria for the seven review questions. The quality of the primary studies was assessed using published appraisal tools. We grouped the findings of the surveys, diagnostic accuracy and intervention studies, and qualitatively analysed differences between outcomes in relation to study quality, setting, populations and, where applicable, the nature of the intervention. We systematically considered each of the selected NSC criteria against the review evidence. RESULTS: The lifetime prevalence of partner violence against women in the general UK population ranged from 13% to 31%, and in clinical populations it was 13-35%. The 1-year prevalence ranged from 4.2% to 6% in the general population. This showed that partner violence against women is a major public health problem and potentially appropriate for screening and intervention. The HITS (Hurts, Insults, Threatens and Screams) scale was the best of several short screening tools for use in health-care settings. Most women patients considered screening acceptable (range 35-99%), although they identified potential harms. The evidence for effectiveness of advocacy is growing, and psychological interventions may be effective, but not necessarily for women identified through screening. No trials of screening programmes measured morbidity and mortality. The acceptability of partner violence screening among health-care professionals ranged from 15% to 95%, and the NSC criterion was not met. There were no cost-effectiveness studies, but a Markov model of a pilot intervention to increase identification of survivors of partner violence in general practice found that such an intervention was potentially cost-effective. CONCLUSIONS: Currently there is insufficient evidence to implement a screening programme for partner violence against women either in health services generally or in specific clinical settings. Recommendations for further research include: trials of system-level interventions and of psychological and advocacy interventions; trials to test theoretically explicit interventions to help understand what works for whom, when and in what contexts; qualitative studies exploring what women want from interventions; cohort studies measuring risk factors, resilience factors and the lifetime trajectory of partner violence; and longitudinal studies measuring the long-term prognosis for survivors of partner violence.


Asunto(s)
Tamizaje Masivo/normas , Maltrato Conyugal/diagnóstico , Actitud del Personal de Salud , Femenino , Servicios de Salud , Humanos , Tamizaje Masivo/métodos , Aceptación de la Atención de Salud , Maltrato Conyugal/prevención & control , Reino Unido
4.
Br Dent J ; 203(11): 645-8, 2007 Dec 08.
Artículo en Inglés | MEDLINE | ID: mdl-18065984

RESUMEN

The face is a common target in assault and consequently the dentist and dental care professional has a part to play in identifying domestic violence. Domestic violence is a term which refers to a wide range of physical, sexual, emotional and financial abuse of people who are, or have been, intimate partners - whether or not they are married or cohabiting. Although domestic violence can take place in any intimate relationship, including gay and lesbian partnerships, and whilst abuse of men by female partners does occur, the great majority and the most severe incidents of domestic violence, are perpetrated by men against women and we have therefore elected refer to the victim of assault in this paper as 'she' for ease of writing.


Asunto(s)
Personal de Odontología , Violencia Doméstica/psicología , Rol Profesional , Femenino , Humanos , Masculino , Guías de Práctica Clínica como Asunto , Reino Unido
5.
Br Dent J ; 201(10): 653-9; discussion 651, 2006 Nov 25.
Artículo en Inglés | MEDLINE | ID: mdl-17128240

RESUMEN

OBJECTIVES: To assess changes in dental team knowledge and awareness about domestic violence following attendance at a brief training intervention. MATERIALS AND METHODS: Seventy-five dental hospital staff at the University of Manchester Dental Hospital attended a two-hour session delivered by Manchester's City Wide NHS Domestic Violence Project manager. Participants completed identical questionnaires immediately before and after the session. Paired t-tests were conducted to determine changes in responses to individual questions before and after training. Independent sample t-tests were also conducted to compare mean responses by sex. RESULTS: Statistically significant improvements were seen in 50% of attitude questions and 100% of knowledge questions. After training, there was improved recognition that interpersonal violence was a health issue and that the dental profession should be more involved in identification of abuse. There was also improved comfort asking about abuse and respondents were less afraid of offending the patient and less likely to blame the victims for being abused. Statistically significant sex differences at baseline were also seen for several items: females obtaining more correct answers at baseline than males. CONCLUSIONS: Brief domestic violence training interventions can be effective in improving knowledge and attitudes amongst a dental team but could lead to false confidence in staff and should be followed by in-depth practical training and the development of appropriate processes for dealing with abuse victims.


Asunto(s)
Personal de Odontología/psicología , Violencia Doméstica/psicología , Conocimientos, Actitudes y Práctica en Salud , Adulto , Personal de Odontología/educación , Femenino , Humanos , Masculino , Rol Profesional/psicología , Encuestas y Cuestionarios
6.
Emerg Med J ; 23(1): 12-7, 2006 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-16373796

RESUMEN

OBJECTIVES: To identify correlates of alcohol related assault injury in the city centre of a European capital city, with particular reference to emergency department (ED) and police interventions, and number and capacity of licensed premises. METHODS: Assaults resulting in ED treatment were studied using a longitudinal controlled intervention, a three stage design during a three year period of rapid expansion in the night-time economy, when ED initiated targeted police interventions were delivered. A controlled ED intervention targeted at high risk night-clubs was carried out. Main outcome measure was ED treatment after assault in licensed premises and the street. RESULTS: Targeted police intervention was associated with substantial reductions in assaults in licensed premises but unexpected increases in street assault were also observed (34% overall: 105% in the principal entertainment thoroughfare). Combined police/ED intervention was associated with a significantly greater reduction compared with police intervention alone (OR = 0.61, 95% CI 0.40 to 0.91). Street assault correlated significantly with numbers and capacity of premises. Risk of assault was 50% greater in and around licensed premises in the city centre compared with those in the suburbs, although dispersion of violence to more licensed premises was not observed. CONCLUSIONS: Marked decreases in licensed premises assaults resulting from targeted policing were enhanced by the intervention of ED and maxillofacial consultants. Capacity of licensed premises was a major predictor of assaults in the city centre street in which they are clustered. City centre assault injury prevention can be achieved through police/ED interventions targeted at high risk licensed premises, which should also target the streets around which these premises are clustered.


Asunto(s)
Consumo de Bebidas Alcohólicas/psicología , Servicio de Urgencia en Hospital/organización & administración , Policia/organización & administración , Violencia/prevención & control , Heridas y Lesiones/prevención & control , Ciudades , Conducta Cooperativa , Humanos , Relaciones Interprofesionales , Concesión de Licencias/estadística & datos numéricos , Registros Médicos , Salud Urbana/estadística & datos numéricos , Violencia/estadística & datos numéricos , Violencia/tendencias , Gales/epidemiología , Heridas y Lesiones/epidemiología , Heridas y Lesiones/etiología
7.
Emerg Med J ; 21(4): 473-7, 2004 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-15208234

RESUMEN

OBJECTIVES: To develop formal processes for the collection, disclosure, and effective use of accident and emergency (A&E) department derived assault injury data for city violence reduction. METHODS: Over a four year period, managed by a multi-agency steering group, A&E data collection, collation, and disclosure processes were developed, instituted, and refined. Consultations and negotiations between agencies identified the most effective and ethical methods, appropriate recipients, and the nature of the information of most use. RESULTS: Disclosure of A&E data to city authorities, the police, and local media drew substantial attention and crime prevention resources to the locations of violence. As a result, a police task force responsible for targeting city street crime was funded, which analysed both A&E and police information. Monthly, electronic transfer of raw, anonymous data to the task force crime analyst informed and prompted violence prevention initiatives by several agencies. Police mounted overt and covert interventions targeted at violence hotspot licensed premises and used the data to oppose, on injury grounds, drinks/entertainment licence applications. Transport authorities established new half hourly night time city centre bus services. The local authority mounted an assault awareness campaign in schools and public libraries, and licensing magistrates used the data to measure, for example, the impact of continuous 36 hour drinks licensing on public safety. CONCLUSIONS: The principal finding of this evaluation was that judicious sharing of unique information about locations and times of violence derived from A&E patients was a powerful and effective means of targeting police and other local resource to bring about violence reduction.


Asunto(s)
Servicio de Urgencia en Hospital/estadística & datos numéricos , Violencia/estadística & datos numéricos , Heridas y Lesiones/epidemiología , Adulto , Conducta Cooperativa , Femenino , Humanos , Comunicación Interdisciplinaria , Masculino , Registros Médicos , Policia/organización & administración , Instituciones Académicas/estadística & datos numéricos , Transportes , Salud Urbana/estadística & datos numéricos , Violencia/prevención & control , Violencia/tendencias , Gales/epidemiología
8.
Cochrane Database Syst Rev ; (2): CD004486, 2004.
Artículo en Inglés | MEDLINE | ID: mdl-15106255

RESUMEN

BACKGROUND: Domestic violence exists in all communities across the world. Healthcare services have a pivotal role in the identification, assessment and response to domestic violence. As the face is a common target in assault, dentists and oral and maxillofacial surgeons are in a unique position to screen for domestic violence in the context of presentation of dental and facial injury. Owing to lack of training, dentists and oral and maxillofacial surgeons may not be the best persons to give advice to someone experiencing domestic violence. Improper advice such as encouragement to leave an abusive relationship may escalate the frequency of violence. It may be more appropriate to refer to specialist agencies for intervention and support. It would, therefore be useful to know whether screening and intervention programmes are effective. OBJECTIVES: (1) To assess the benefits and harms of intervention programmes employed to reduce and or prevent domestic violence in adults with dental and/or facial injuries.(2) To assess the benefits and harms of screening and the use of different screening tools in the detection of the proportion of adult victims of domestic violence who present with dental and/or facial injury. SEARCH STRATEGY: We searched the Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, PsycINFO and Lilacs databases. No language restrictions were applied. Personal contacts were used and international domestic violence organisations were contacted to identify any unpublished trials. Last search was done February 2004. SELECTION CRITERIA: Randomised controlled trials involving adults aged 16 years and over presenting with dental and/or facial injury relating to domestic violence in any healthcare setting. DATA COLLECTION AND ANALYSIS: Screening of eligible studies was conducted in duplicate and independently by two reviewers. Results were to be expressed as random effects models using weighted mean differences for continuous outcomes and relative risk for dichotomous outcomes with 95% confidence interval. Heterogeneity was to be investigated including both clinical and methodological factors. MAIN RESULTS: No eligible randomised controlled trials (RCTs) were identified. REVIEWERS' CONCLUSIONS: There is no evidence to support or refute that screening for domestic violence in adults with dental or facial injury is beneficial nor that it causes harm. Screening tools to detect domestic violence exist but no RCTs have specifically evaluated their effectiveness for patients presenting with facial and or dental injuries. There is also lack of evidence that intervention programmes are effective at reducing frequency of physical assaults and at reducing the severity of facial injuries.


Asunto(s)
Violencia Doméstica/prevención & control , Traumatismos Faciales/etiología , Traumatismos de los Dientes/etiología , Humanos
9.
Arch Womens Ment Health ; 7(1): 65-70, 2004 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-14963735

RESUMEN

The Marcé Clinical Audit is an ongoing data collection exercise that gathers socio-demographic and clinical information about mothers and their infants, admitted jointly to specialist units in UK psychiatric hospitals. The maternal and parenting outcomes, in particular of mothers with schizophrenia and mothers who harm themselves and/or their infants, were determined and analysed. The majority of women had a primary diagnosis of either depression (43%) or schizophrenia (21%). Mothers with schizophrenia were three times more likely to experience a poor outcome than non-schizophrenic mothers, were more likely to be separated from their infant at discharge and were perceived, by staff, to be at greater risk of harming their infant. They were, however, shown to be no more likely to cause actual harm to their infant, or themselves, than non-schizophrenic mothers.


Asunto(s)
Maltrato a los Niños/prevención & control , Hospitales Psiquiátricos/estadística & datos numéricos , Relaciones Madre-Hijo , Madres/psicología , Atención Posnatal/estadística & datos numéricos , Psicología del Esquizofrénico , Adolescente , Adulto , Femenino , Humanos , Lactante , Recién Nacido , Auditoría Médica , Persona de Mediana Edad , Madres/estadística & datos numéricos , Admisión del Paciente/estadística & datos numéricos , Atención Posnatal/organización & administración , Conducta Autodestructiva , Resultado del Tratamiento , Reino Unido , Revisión de Utilización de Recursos
10.
Phys Rev Lett ; 90(18): 181802, 2003 May 09.
Artículo en Inglés | MEDLINE | ID: mdl-12785998

RESUMEN

From electron-positron collision data collected with the CLEO detector operating at Cornell Electron Storage Ring near sqrt[s]=10.6 GeV, improved measurements of the branching fractions for tau decays into three explicitly identified hadrons and a neutrino are presented as B(tau(-)-->pi(-)pi(+)pi(-)nu(tau))=(9.13+/-0.05+/-0.46)%, B(tau(-)-->K-pi(+)pi(-)nu(tau))=(3.84+/-0.14+/-0.38) x 10(-3), B(tau(-)-->K-K+pi(-)nu(tau))=(1.55+/-0.06+/-0.09) x 10(-3), and B(tau(-)-->K-K+K-nu(tau))<3.7 x 10(-5) at 90% C.L., where the uncertainties are statistical and systematic, respectively.

11.
Phys Rev Lett ; 89(8): 081803, 2002 Aug 19.
Artículo en Inglés | MEDLINE | ID: mdl-12190458

RESUMEN

We determine the weak coupling /V(cb)/ between the b and c quarks using a sample of 3 x 10(6) BB; events in the CLEO detector at the Cornell Electron Storage Ring. We determine the yield of reconstructed B-->D*l nu; decays as a function of w, the boost of the D* in the B rest frame, and from this we obtain the differential decay rate d Gamma/dw. By extrapolating d Gamma/dw to w=1, the kinematic end point at which the D* is at rest relative to the B, we extract the product /V(cb)/F(1), where F(1) is the form factor at w=1. Combined with theoretical results for F(1) we determine /V(cb)/=0.0469+/-0.0014(stat)+/-0.0020(syst)+/-0.0018(theor).

12.
Phys Rev Lett ; 88(10): 101803, 2002 Mar 11.
Artículo en Inglés | MEDLINE | ID: mdl-11909343

RESUMEN

We report the first observation of the exclusive decays B-->D((*))K(*-), using 9.66 x 10(6) BB pairs collected at the Upsilon(4S) with the CLEO detector. We measure the following branching fractions: B(B--->D(0)K(*-)) = (6.1+/-1.6+/-1.7)x10(-4), B(B(0)-->D(+)K(*-)) = (3.7+/-1.5+/-1.0)x10(-4), B(B(0)-->D(*+)K(*-)) = (3.8+/-1.3+/-0.8)x10(-4), and B(B--->D(*0)K(*-)) = (7.7+/-2.2+/-2.6)x10(-4). The B-->D(*)K(*-) branching ratios are the averages of those corresponding to the 00 and 11 helicity states. The errors shown are statistical and systematic, respectively.

13.
Int J Oral Maxillofac Surg ; 31(6): 657-63, 2002 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-12521325

RESUMEN

The maxillofacial region is by far the most frequently selected target in assaults on adults. There is a causal link between alcohol intoxication and injury. Therefore, oral and maxillofacial surgery is, in effect, the lead speciality for those injured in violence and has a responsibility to orchestrate holistic care that takes into account mental health needs. Recent years have also seen a determined effort by oral and maxillofacial surgeons to get involved in wider issues of prevention, exemplified by the national UK BAOMS Facial Injuries Awareness Week. Multi-agency prevention, not just with mental health professionals in the case of individual patients, but also with emergency medicine, public health, local government, the police and the voluntary sector is key to success. Given the potential complexity of collaborations like this, it is important to understand what works in multi-agency prevention. This paper reviews successful interventions: their rationale and how oral and maxillofacial surgeons can contribute to local injury prevention.


Asunto(s)
Intoxicación Alcohólica , Traumatismos Maxilofaciales/prevención & control , Rol del Médico , Cirugía Bucal , Violencia/prevención & control , Adolescente , Adulto , Intoxicación Alcohólica/diagnóstico , Intoxicación Alcohólica/prevención & control , Niño , Relaciones Comunidad-Institución , Medicina de Emergencia , Etanol/envenenamiento , Traumatismos Faciales/prevención & control , Femenino , Gobierno , Educación en Salud , Política de Salud , Promoción de la Salud , Salud Holística , Humanos , Relaciones Interinstitucionales , Traumatismos Maxilofaciales/terapia , Salud Mental , Policia , Vigilancia de la Población , Prevención Primaria , Salud Pública , Administración en Salud Pública , Reino Unido
14.
Phys Rev Lett ; 86(17): 3718-21, 2001 Apr 23.
Artículo en Inglés | MEDLINE | ID: mdl-11329307

RESUMEN

We have studied two-body charmless hadronic decays of B mesons into the final states straight phiK and phiK(*). Using 9.7 million B&Bmacr; pairs collected with the CLEO II detector, we observe the decays B- --> phiK- and B0--> phiK(*0) with the following branching fractions: B(B--->phiK-) = (5.5(+2.1)(-1.8)+/-0.6)x10(-6) and B(B0--> phiK(*0)) = (11.5(+4.5+1.8)(-3.7-1.7))x10(-6). We also see evidence for the decays B0-->phiK0 and B---> phiK(*-). However, since the statistical significance is not overwhelming for these modes, we determine upper limits of <12.3x10(-6) and <22.5x10(-6) ( 90% confidence level), respectively.

15.
Phys Rev Lett ; 86(13): 2737-41, 2001 Mar 26.
Artículo en Inglés | MEDLINE | ID: mdl-11290027

RESUMEN

We analyze 9.7x10(6) B_B pairs recorded with the CLEO detector to determine the production ratio of charged to neutral B-meson pairs produced at the Upsilon(4S) resonance. We measure the rates for B0-->J/psiK((*)0) and B+-->J/psiK((*)+) decays and use the world-average B-meson lifetime ratio to extract the relative widths f(+-) / f(00) = gamma(Upsilon(4S)-->B+B-) / gamma(Upsilon(4S)-->B0 B-0)) = 1.04+/-0.07(stat)+/-0.04(syst). With the assumption that f(+-)+f(00) = 1, we obtain f(00) = 0.49+/-0.02(stat)+/-0.01(syst) and f(+-) = 0.51+/-0.02(stat)+/-0.01(syst). This production ratio and its uncertainty apply to all exclusive B-meson branching fractions measured at the Upsilon(4S) resonance.

17.
Inj Prev ; 6(1): 36-40, 2000 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-10728540

RESUMEN

OBJECTIVE: To evaluate the effectiveness, in terms of injury prevention, of toughened pint glassware in bars. DESIGN: Randomised controlled trial. SETTING: A random sample of 57 bars in South Wales, West Midlands, and West of England. SUBJECTS: A total of 1229 bar workers. INTERVENTION: Complete replacement of pint glasses with annealed (control) or toughened (intervention) glassware. MAIN OUTCOME MEASURES: Bar staff injuries recorded monthly: number, site, and severity (lifestyle impact; treatment need) of injuries. RESULTS: Ninety eight bar staff experienced 115 injuries: 43 in the control group, 72 in the intervention group. Adjusting for people at risk gave a relative risk (RR) of 1.48 (confidence interval (CI) 1.02 to 2.15). Similarly, adjusting for hours worked gave RR 1.57 (CI 1.08 to 2.29). Thus, injury rate was 60% higher in the intervention group (p<0.05), with no significant difference in severity. Most were hand injuries requiring first aid. Injuries tended to occur simultaneously in more than one body part in the intervention group, reportedly caused by spontaneous disintegration of toughened glassware. Impact resistance testing showed the energy required to break annealed glass (1.8 +/- 0.2 J) was greater than that for toughened glass (1.4 +/- 0.2 J), though the difference was not significant. CONCLUSIONS: Glass with lower impact resistance caused more injuries. "Toughened" glassware had lower impact resistance. Standards for toughening need to be developed.


Asunto(s)
Prevención de Accidentes , Accidentes de Trabajo/prevención & control , Consumo de Bebidas Alcohólicas , Vidrio/normas , Enfermedades Profesionales/prevención & control , Heridas y Lesiones/epidemiología , Adulto , Distribución por Edad , Intervalos de Confianza , Femenino , Humanos , Incidencia , Puntaje de Gravedad del Traumatismo , Masculino , Valores de Referencia , Restaurantes , Factores de Riesgo , Distribución por Sexo , Reino Unido/epidemiología , Violencia/prevención & control , Violencia/estadística & datos numéricos , Heridas y Lesiones/prevención & control
18.
J Anat ; 190 ( Pt 1): 115-24, 1997 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-9034887

RESUMEN

Morphometric analyses of the neurons and microvessels of perfusion-fixed hypogastric (HG) and 13th thoracic (T13) ganglia have been performed in male Wistar rats aged 4, 24 and 30 mo. Estimations of HG volume employing the Cavalieri principle have also been performed and showed that the size of the aged HG is increased by 42%. Routine histological staining of the ganglia with Masson's trichrome indicated that this may be due to the increased amount of interstitial connective tissue which was apparent in the aged animals. The number of neurons per unit area progressively decreased by 38% between ages 4 and 24 mo and by 16% between ages 24 and 30 mo in the HG and by 25% (4 and 24 mo) and 2% (24 and 30 mo) in the T13 ganglion. The total number of neurons in the HG however, estimated by a physical disector analysis, was constant with age. The number of microvessels per unit area, microvessel diameter, neuronal and nuclear areas did not differ significantly between the 3 age groups studied. This observed increase in ganglionic volume and decrease in neuronal packing density may be associated with changes in the extracellular matrix, in particular in glycosaminoglycans whose presence was indicated by metachromasia of the ganglia with toluidine blue. The extracellular matrix was therefore characterised using a panel of monoclonal antibodies against glycosaminoglycans and laminin. Chondroitin-6 sulphate and chondroitin-4 sulphate were present in the interstitial connective tissue, and there was an increase in the expression of both these epitopes at 24 mo, noteably surrounding neuron cell bodies. The expression of chondroitin-4 sulphate/dermatan sulphate was unchanged, thus implying a decreased expression of dermatan sulphate with age. Keratan sulphate and the native chondroitin sulphate epitopes were absent from the ganglia at both ages. Laminin expression was increased in the aged ganglia. It is therefore clear that the constituents of the extracellular matrix are not constant throughout the adult lifespan and that the extracellular matrix may influence neuronal survival in old age. This is the first report characterising age-related changes in the extracellular matrix of autonomic ganglia.


Asunto(s)
Envejecimiento/fisiología , Plexo Hipogástrico/anatomía & histología , Nervios Torácicos/anatomía & histología , Animales , Matriz Extracelular/química , Matriz Extracelular/ultraestructura , Glicosaminoglicanos/análisis , Plexo Hipogástrico/química , Plexo Hipogástrico/ultraestructura , Laminina/análisis , Masculino , Ratas , Ratas Wistar , Nervios Torácicos/química , Nervios Torácicos/ultraestructura
19.
Neurosci Lett ; 194(3): 157-60, 1995 Jul 21.
Artículo en Inglés | MEDLINE | ID: mdl-7478227

RESUMEN

The rat hypogastric ganglion (HG) contains populations of both sympathetic and parasympathetic postganglionic neurons which supply the lower pelvic viscera. These neuron populations can be identified by tyrosine hydroxylase (TH) and NADPH-diaphorase (NADPH-d) staining, respectively. The effects of age on the distribution of synapsin I, a nerve terminal marker, in relation to these neuron populations has been investigated in young adult and aged rats. Most synapsin staining was axosomatic and was markedly reduced in the aged animals particularly in relation to sympathetic (NADPH-d-negative/TH-positive) neurons. Image analysis of synapsin I staining in relation to individual sympathetic neurons confirmed that there was a reduction with age of about 50% but no change in synapsin I staining in relation to parasympathetic neurons. These results suggest that synaptic transmission and peripheral integration may be affected in old age and that the autonomic control of the pelvic viscera may be compromised as a result, particularly with regard to the sympathetic innervation. Other autonomic ganglia were also studied for comparison but no such age-related differences were observed.


Asunto(s)
Envejecimiento/metabolismo , Plexo Hipogástrico/metabolismo , Sinapsinas/metabolismo , Transmisión Sináptica/fisiología , Factores de Edad , Animales , Inmunohistoquímica , Masculino , Fibras Nerviosas/inmunología , Ratas , Ratas Wistar , Sistema Nervioso Simpático/inmunología , Sistema Nervioso Simpático/metabolismo , Tirosina 3-Monooxigenasa/metabolismo
20.
Health Libr Rev ; 11(4): 253-61, 1994 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-10141713

RESUMEN

As the focus of UK health care moves towards the achievement of health gain, information on health outcomes is required by health care commissioners and providers in order to bring about improved patient outcomes. The information required includes health care activity and population data, and textual and bibliographic information to identify published outcomes studies and current health outcomes activities. A survey of enquiries received by the UK Clearing House on Health Outcomes was undertaken to ascertain the nature and level of enquiries, and their geographical and organizational origins in the UK. The study cannot claim to be a comprehensive review of the demand for and use of health outcomes information. What it does illustrate is the still developmental stage of health outcomes activity in the UK. Providers are the major group of users of outcomes information. The potential impact of health outcomes information on health care commissioning has yet to be realized.


Asunto(s)
Servicios de Información/estadística & datos numéricos , Evaluación de Resultado en la Atención de Salud/estadística & datos numéricos , Medicina Estatal/normas , Recolección de Datos , Investigación sobre Servicios de Salud , Reino Unido
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