RESUMEN
Several compounds of great pharmacological interest contain the triazole and imidazole rings. In order to find new drugs with antileishmanial activity we have synthesized and evaluated new imidazole and triazole compounds carrying either the carbaldehyde or the difluoromethylene functionalities against promastigote forms of Leishmania amazonensis. Among the compounds tested difluoromethylene azoles 4b and 8f have inhibited the parasite growth significantly. Our results show that the introduction of the difluoromethylene moieties has turned the inactive carbaldehydes into active antileishmanial compounds.
Asunto(s)
Antiprotozoarios/síntesis química , Antiprotozoarios/farmacología , Azoles/síntesis química , Azoles/farmacología , Leishmania mexicana/efectos de los fármacos , Animales , Antiprotozoarios/química , Azoles/química , Femenino , Imidazoles/síntesis química , Imidazoles/química , Imidazoles/farmacología , Triazoles/síntesis química , Triazoles/química , Triazoles/farmacologíaAsunto(s)
Laparoscopía , Esplenectomía/métodos , Analgésicos Opioides/uso terapéutico , Actitud del Personal de Salud , Niño , Ingestión de Alimentos , Estudios de Factibilidad , Cirugía General , Enfermedades Hematológicas/cirugía , Humanos , Procedimientos Quirúrgicos Mínimamente Invasivos , Dolor Postoperatorio/tratamiento farmacológico , Cuidados Posoperatorios , Estudios Retrospectivos , SeguridadRESUMEN
The study examines both the attitudes towards the role of women in society and the psychological masculinity/femininity manifested by a small group of Cuban-American college women. In Miami, 31 such women completed the Attitudes Towards Women Scale and the Personal Attributes Questionnaire. Overall, the means for this group corresponded with the established American norms. The authors thought that age, number of years in the U.S., mother's educational level, position in family and relative fluency of English would affect both AWS and PAQ scores. Only the last variable appeared to have an impact, with those women who reported fluency in both English and Spanish obtaining more liberal AWS scores than those who reported being less fluent in English.