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1.
Am J Forensic Med Pathol ; 43(3): 249-252, 2022 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-35315374

RESUMEN

ABSTRACT: Autoerotic death is defined as an accidental death that occurs when some type of apparatus is used to enhance sexual stimulation and causes an unintended death. We present the case of an atypical autoerotic death of a 23-year-old man found deceased in a bathroom. An electrical cord with a standard wall plug on one end and exposed wires twisted into loops on the other end was on the floor near his body. Minute black burns were present on each nipple. The outlet was protected by a ground fault circuit interrupter that was demonstrated to be in working order. An electrical consultant concluded that the cause of death could not be electrocution. Ground fault circuit interrupters work by detecting differences in current within a circuit. If a ground fault occurs, the circuit is broken to prevent a fatal electrocution. In the present case, the ground fault circuit interrupter did not shut off because the decedent had wired himself in parallel with the circuit. This, with the other scene findings, indicated this to be a case of atypical autoerotic death. Autoerotic deaths by means other than asphyxiation are rare. This case serves to illustrate the circumstances of an atypical autoerotic death by means of electrocution.


Asunto(s)
Trastornos Parafílicos , Adulto , Asfixia/etiología , Humanos , Masculino , Trastornos Parafílicos/complicaciones , Adulto Joven
2.
Forensic Sci Int ; 304: 109962, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31610334

RESUMEN

Melatonin (MEL) is a neurohormone in humans produced in a number of locations. Starting with the amino acid tryptophan, MEL is produced through a number of enzymatic steps that includes serotonin as an intermediate compound. The primary production of MEL is in the pineal gland located in the brain. It is directly associated with the the suprachiasmatic nucleus (SCN) located in the hypothalamus. In young and adult humans, the blood levels of MEL are typically in the picogram levels and produced in a cyclic schedule highly regulated by light detected in the retina by intrinsically photosensitive retinal ganglion cells (ipRGCs), resulting in production primarily during periods of darkness. During periods of light, MEL levels are typically very low or undetectable. Basal levels of MEL in infants have been observed to be either undetectable or also in the picogram levels, although some medical treatment has involved administration of exogenous MEL resulting in peak levels in the nanogram range. MEL is considered to be well tolerated and there have been limited reports of toxicity. In this case, an infant was found unresponsive and cause of death was ruled as Undetermined. Melatonin was detected in the peripheral blood at a concentration of 1,400ng/mL.


Asunto(s)
Depresores del Sistema Nervioso Central/envenenamiento , Muerte Súbita/etiología , Melatonina/envenenamiento , Depresores del Sistema Nervioso Central/administración & dosificación , Depresores del Sistema Nervioso Central/sangre , Cromatografía Liquida , Femenino , Cromatografía de Gases y Espectrometría de Masas , Humanos , Lactante , Melatonina/administración & dosificación , Melatonina/sangre , Espectrometría de Masas en Tándem , Gemelos
3.
J Anal Toxicol ; 40(7): 543-5, 2016 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-27405363

RESUMEN

It is reasonable to expect the presence of multiple drugs to present a complicated picture of toxicity. We report a fatal case involving a young man who purchased illicit drugs and knowingly consumed them. After consuming these drugs and going to sleep in his friend's car, he was found unresponsive the next morning with no signs of physical violence. Drugs found in the peripheral blood at autopsy were oxymorphone, methylone and ethanol at concentrations of 0.106, 0.50 and 130 mg/dL, respectively. The levels of oxymorphone and methylone in peripheral blood were comparable to those observed in other reported fatalities. Cocaine and benzoylecgonine were detected in the urine but not in the blood. Measureable concentrations were also observed for oxymorphone and methylone in urine, liver, kidney and bile. The physical findings at autopsy included pulmonary edema. This is the only reported fatal case involving this combination of drugs encountered in our laboratory.


Asunto(s)
Sobredosis de Droga/diagnóstico , Etanol/metabolismo , Metanfetamina/análogos & derivados , Oximorfona/metabolismo , Adulto , Etanol/sangre , Etanol/orina , Resultado Fatal , Toxicología Forense , Humanos , Masculino , Metanfetamina/sangre , Metanfetamina/metabolismo , Metanfetamina/orina , Oximorfona/sangre , Oximorfona/orina , Edema Pulmonar/diagnóstico
4.
Acad Forensic Pathol ; 6(4): 673-678, 2016 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31239939

RESUMEN

The coexistence of adult polycystic kidney disease and aortic dissection should be recognized by forensic pathologists and radiologists. Two cases with postmortem computed tomography prior to autopsy illustrate the appearance of polycystic kidneys and the hemorrhage patterns that provide clues to the presence and approximate location of the aortic dissections. Optimal imaging technique is discussed.

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