RESUMEN
Angiosarcoma in the setting of immunosuppressed renal transplant recipients is exceedingly rare. In this report, we describe the occurrence of angiosarcoma arising at an arteriovenous fistula site of a 39-year-old renal transplant recipient that clinically mimicked a thrombosed aneurysm. These tumors are histologically high-grade and clinically aggressive malignancies. They have a predilection for arteriovenous fistula sites. The literature on this uncommon entity is reviewed and possible histogenesis is discussed.
Asunto(s)
Fístula Arteriovenosa/patología , Hemangiosarcoma/patología , Huésped Inmunocomprometido , Trasplante de Riñón/inmunología , Neoplasias Vasculares/patología , Adulto , Biopsia con Aguja , Progresión de la Enfermedad , Resultado Fatal , Hemangiosarcoma/etiología , Hemangiosarcoma/cirugía , Humanos , Inmunohistoquímica , Trasplante de Riñón/efectos adversos , Masculino , Medición de Riesgo , Neoplasias Vasculares/etiología , Neoplasias Vasculares/cirugíaRESUMEN
An unusual ossifying lesion arising within the median nerve of a young adult male is presented. While ectopic ossification has been described in a large number of sites, intraneural ossification is an uncommon event and usually occurs in association with a pre-existing intraneural neoplasm. This case, in contrast, bears striking histopathological resemblance to myositis ossificans with prominent zonation. We believe that this may represent the first example of a benign myositis ossificans-like lesion of nerve.
Asunto(s)
Nervio Mediano/patología , Miositis Osificante/patología , Osificación Heterotópica/patología , Enfermedades del Sistema Nervioso Periférico/patología , Adulto , Humanos , MasculinoRESUMEN
The rarity of chondrosarcomas, limited experience with the spectrum of histopathologic and cytologic features, and the drastic treatment options that ensue present a diagnostic challenge to many cytopathologists who interpret needle aspirate biopsies of these neoplasms. Twelve fine needle (FNA) aspirates were performed at University Hospitals of Cleveland on eight patients with primary (three), locally recurrent (seven) or metastatic (two) chondrosarcoma between 1980 and 1991. The cytologic features of chondrosarcoma in all three clinical settings were characterized by the presence of isolated or loosely cohesive aggregates of oval or polygonal chondrocytes with vacuolated or granular cytoplasm and a background of chondroid matrix. FNA cytology is utilized most commonly in the diagnosis of recurrent and metastatic chondrosarcoma. FNA cytology, when employed in the diagnosis of chondrosarcoma, necessitates the same considerations employed in evaluating surgical biopsies. They include (1) the cytologic features and their limitations and differential diagnoses, (2) the clinical and radiographic data, and (3) the clinical impact of the cytologic diagnosis.
