RESUMEN
Objective: Hepatitis B virus (HBV) infection is a major health threat worldwide, especially in developing countries. We aimed to investigate the impact of hepatitis B carrier on pregnancy complications in pregnant women, in China. Methods: This retrospective cohort study was conducted by using data from the EHR system of Longhua District People's Hospital in Shenzhen, China, from January 2018 to June 2022. Binary logistic regression was used to evaluate the relationship between HBsAg carrier status and pregnancy complications and pregnancy outcomes. Results: The study included 2095 HBsAg carriers (exposed group) and 23,019 normal pregnant women (unexposed group). Pregnant women in the exposed group were older than the pregnant women in the unexposed group (29 (27,32) vs. 29 (26,32), p < 0.001). In addition, the incidence of some adverse pregnancy complications in the exposure group was lower than that in the unexposed group, including hypothyroidism of pregnancy (adjusted odds ratio [aOR], 0.779; 95% confidence interval [CI], 0.617-0.984; p = 0.036), hyperthyroidism of pregnancy (aOR, 0.388; 95% CI, 0.159-0.984; p = 0.038), pregnancy induced hypertension (aOR, 0.699; 95% CI, 0.551-0.887; p = 0.003), antepartum hemorrhage (aOR, 0.294; 95% CI, 0.093-0.929; p = 0.037). However, compared with the unexposed group, the exposed group had a higher risk of lower birth weight (aOR, 1.12; 95% CI, 1.02-1.23; p = 0.018) and intrahepatic cholestasis of pregnancy (aOR, 2.888, 95% CI, 2.207-3.780; p < 0.001). Conclusion: The prevalence rate of HBsAg carriers in pregnant women in Longhua District of Shenzhen was 8.34%. Compared with normal pregnant women, HBsAg carriers have a higher risk of ICP, a lower risk of gestational hypothyroidism and PIH, and a lower birth weight of their infants.
RESUMEN
(1) Objective: To explore Chinese residents' willingness to receive COVID-19 vaccine booster shots and identify predictors of the level of willingness based on the health belief model (HBM). (2) Methods: The snowball sampling method was used to distribute online questionnaires. A chi-square test was used to analyze the relationship between different variables. The causal relationship between HBM-related factors and booster vaccination intentions was explored by Structural equation modeling (SEM). (3) Results: A total of 898 complete responses were included; 64.3% had already received the booster injection. Most respondents intended to vaccinate themselves, while 16.1% were hesitant. Nearly half of the respondents chose to take the booster injection to support China's vaccination policy. Using the SEM, perceived susceptibility and perceived barriers were found to have a negative effect on booster vaccination intentions, whereas perceived benefit and cues to action positively affected booster vaccination intentions in the HBM. (4) Conclusions: Factors included in this study have different effects on the willingness to take the COVID-19 booster injections. Sociodemographic characteristics and characteristics of participants' COVID-19 vaccination have a significant effect on the willingness to receive vaccine booster shots. The HBM constructs can serve as good predictors of the acceptance of vaccine booster shots with the exception of perceived severity, which may benefit health officials in terms of conducting targeted strategies in vaccine programs.