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1.
Acta Biochim Pol ; 48(2): 429-42, 2001.
Artículo en Inglés | MEDLINE | ID: mdl-11732613

RESUMEN

This review presents a brief account of the chemistry and mechanistic aspects of aryl H-phosphonates, and selected applications of this class of compounds as intermediates in the synthesis of a wide range of biologically important analogues of nucleoside phosphates, and oligonucleotides, in which the phosphate moieties are replaced by other structurally related groups. The aryl nucleoside H-phosphonates, compounds of controlled reactivity, have proven to be more versatile and superior to various mixed anhydrides as synthetic intermediates, particularly for preparation of nucleotide analogues bearing P-N or P-S bonds in various configurational arrangements at the phosphate moiety.


Asunto(s)
Nucleótidos/química , Nucleótidos/síntesis química , Catálisis , Esterificación , Métodos , Estructura Molecular , Fosfatos/química
2.
Nucleosides Nucleotides Nucleic Acids ; 19(10-12): 1487-503, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-11200254

RESUMEN

Reactions of nucleoside H-phosphonates with various diols using different types of condensing agents have been studied. Depending on the coupling procedure and the length of a polymethylene chain of the diol, acyclic H-phosphonate diesters or cyclic phosphite triesters were formed. The course of oxidation with iodine to produce cyclic nucleoside alkyl phosphotriesters or hydroxyalkyl nucleoside phosphodiesters can be controlled by the amount of water present in the reaction medium.


Asunto(s)
Indicadores y Reactivos/química , Nucleósidos/química , Organofosfonatos/química , Espectroscopía de Resonancia Magnética , Espectrometría de Masas
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