Bleeding risk factors affecting warfarin therapy in the elderly with atrial fibrillation.

PURPOSE: Inadequate anticoagulation among elderly individuals with atrial fibrillation (AF) is a common problem. This synthesis of the literature review describes the pathophysiology of AF, explains the mechanism of action of warfarin (Coumadin), identifies factors that contribute to warfarin (Coumadin)-associated bleeding in the elderly population, and explores alternatives to warfarin (Coumadin) therapy. Implications for advanced practice nurse practice, education, and research will be discussed. METHODS: A literature search was conducted using Academic Search Premier, CINAHL Plus with Full Text, and Medline from 1999 to 2012. Search terms included warfarin (Coumadin), warfarin (Coumadin) genetics, diet, interactions, bleeding, atrial fibrillation, genetics, anticoagulation clinic, dabigatran, apixaban, rivaroxaban, and elderly. RESULTS: The literature indicates that the potential bleeding risk associated with warfarin (Coumadin) therapy limits its use in the elderly population. However, some studies have found warfarin (Coumadin) to be more effective than aspirin in preventing stroke. The safety profiles of both medications were comparable; also, effective alternatives to warfarin (Coumadin) that do not require routine testing are now available. CONCLUSIONS: Atrial fibrillation increases the probability of an embolic stroke, especially for the elderly population. Stroke risk and bleeding risk tools, in conjunction with patient preference, determine the best stroke prevention treatment. Anticoagulant clinics manage long-term warfarin (Coumadin) therapy effectively. Newer anticoagulants offer effective alternatives to warfarin (Coumadin) therapy.

A pilot study on delirium in the intensive care unit: a creative inquiry project with undergraduate nursing students.

INTRODUCTION: Delirium continues to be a major issue in intensive care units (ICUs). Sedation and lack of rapid eye movement (REM) sleep could be important factors in the development of delirium. Improper sedation may interfere with a patient's sleep pattern, specifically time spent in REM sleep, and could be a contributor to the development of delirium. The research team has discovered through this pilot study that there is a possible correlation between sedation, disruptions, and sleep. The goal of our research was to determine the relationship between these variables using a sleep monitor to capture actual sleep activity compared with patient characteristics and real-time activity in the ICU environment. MATERIALS AND METHODS: This was a pilot study of 7 new patients, aged 65 years or older, who were intubated and sedated. Data on patient sleep cycles were collected using a wireless sleep monitor. A time sheet was placed outside each room to record time and type of interruption during nighttime hours (9 PM-6 AM). The patients were observed for 1 to 7 nights dependent on their length of stay in the ICU. RESULTS: Preliminary results demonstrated that, on average, between 9 PM and 6 AM, 48% remained awake (range, 8%-88%), 30% were in light sleep (range, 2%-50%), 18.5% were in REM (range, 2%-60%), and 3.4% were in a deep sleep (range, 0%-9%). Subject 1 remained awake 52% to 88% of the time during the entire admission of 7 days, had an Intensive Care Delirium Screening Checklist score of 5, and had a self-extubation; sedation ordered was Versed as needed. Subject 5 had no interventions done between 12 midnight and 4:50 AM, with the exception of turning once, and had an REM recorded of 60% on 1 night, which equals to 4 hours 49 minutes of rest. All patients with the exception of 1 were on fentanyl and Versed drips with varying dose adjustments throughout their admission. IMPLICATIONS: Preliminary results show that there is a relationship between lack of REM sleep and delirium. The pilot study was a useful model to demonstrate the need for further investigation in a larger population.

A retrospective study evaluating response time and survival from a cardiopulmonary arrest: a creative inquiry project with undergraduate nursing students.

Cardiopulmonary arrest is a major health problem that claims lives daily in the United States. The adoption of a new standard of care or healthcare technology needs to be evaluated based on patient outcomes. This review focuses on this problem and possible solutions. This retrospective study reviews clinical characteristics of cardiac resuscitative events associated with "code blue" team response. Team-based investigations are led by a faculty mentor and typically span 2 to 4 semesters. Students take ownership of their projects and take the risks necessary to solve problems and get answers. This review indicates areas of concern that need to be improved to create better patient outcomes. Findings include that improved documentation will provide data elements for review analysis that then may be utilized to improve care related to cardiac arrest.

Energize staff to create a research agenda.

There is a need to explore and align priorities for building the foundation for nursing research in any institution. The Delphi technique was chosen as means of setting priorities for nursing research. This method enlisted feedback from all levels of nurses from various practice areas and various nursing roles. A series of 3 rounds of surveys provided feedback. Mixed methods were utilized to reach consensus on the various themes/topics that emerged in each round. In the final survey round, nurses ranked the final themes as to the level of importance, which resulted in identification of the key top 5 priorities. The priorities are the foundation for a research agenda for the coming years. The nursing research council, led by the clinical nurse specialist chairperson, reviewed the results and generated a comprehensive review of literature for current evidence on each priority topic. Evidence was critiqued, rated, and resulted in research questions that formulated the research agenda. The priorities were integrated within the pillars of excellence that are the foundation of the institutions' strategic goals. Using this technique provides a beneficial and structured way to gain input from those who need to own the work of building nursing research within an institution. Positive factors, such as beginning with input from all levels, the ease of providing feedback, and using a Delphi method study to bring alignment within an organization, serve to strengthen nursing research into a much broader scope and focus.

Amiodarone use to prevent postoperative atrial fibrillation after cardiac surgery.

Atrial fibrillation is the most common complication occurring after coronary artery bypass graft surgery. The purpose of this article was to examine the incidence of, risk factors related to, and complications caused by postoperative atrial fibrillation. The pathophysiology and treatment of atrial fibrillation and postoperative atrial fibrillation will also be discussed.

Functional status versus quality of life: where does the evidence lead us?

The interchangeable use of functional status with quality of life has lead to various interpretations when discussing outcomes related to functional status. The literature revealed gaps in the measurement and blurred conceptualization of functional status. Given the prognostic importance of functional status measures, the results highlight the importance of developing a reliable and efficient means of obtaining a measure of functional status resulting in the advancement of nursing science. Having a clear and concise measure of functional status will enable clinicians to implement effect treatment plans that would lead to a faster recovery, higher level of functional status, and a greater well-being.

Evidence-based practice in a military intensive care unit family visitation.

BACKGROUND: The dissatisfaction of family members with a restrictive visiting policy in a combined intensive care and step-down unit provides an opportunity for staff to develop better ways to meet the needs of patients and their families. A review of the evidence-based practice (EBP) literature as the measure of significance indicated that less restrictive visitation policies enhance patient and family satisfaction and offer many physiologic and psychological benefits to the patient. OBJECTIVE: The purpose of this study was to determine whether a less restrictive visitation policy could be implemented in the adult critical care department of a naval medical center. METHODS: Staff was educated on the use of EBP, specifically the Iowa-based model, and a less restrictive visitation policy was developed and implemented. RESULTS: Evaluation of the postintervention survey findings revealed higher patient and family satisfaction. CONCLUSIONS: The findings from this EBP project suggest that a more open visitation policy is feasible in adult critical care units, with an increase in overall satisfaction of patients and their families with regard to their stay in the intensive care unit.

Skill set requirements for nurses deployed with an expeditionary medical unit based on lessons learned.

Based in Kuwait 3 years apart, the authors recount how nurses and corps staff, along with their physician counterparts, came together to form well-run medical facilities under adverse circumstances. Their respective hospitals became competent organizations because of specific formulas for success, along with preparation, identification of required skill sets, and making improvements based on experience. This article describes the training of medical, nursing, and corps staff, the facilities and resources required for managing casualties, and some of the more commonly encountered combat injuries and conditions.

Cardiopulmonary resuscitation: how far have we come?

In the 43 years since it was first described, cardiopulmonary resuscitation (CPR) has grown from an obscure medical theory to a basic first aid skill taught to adults and is now the near-universal technique used in CPR instruction. This article provides insight into the history of CPR. We explore the phenomenon of sudden cardiac arrest, the historical roots of CPR, current practice data and recommendations, and the society's role in the development of this life-saving technique. We conclude with a review of CPR's economic impact on the healthcare system and the ethical and policy issues surrounding CPR.

The use of propofol in the mechanically ventilated medical/surgical intensive care patient: is it the right choice?

This article provides a review of the use of propofol in the mechanically ventilated patient. The indications for the administration of propofol are presented as well as the contraindications, adverse effects, and nursing care.